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Performance and complications of lumbar puncture in memory clinics: Results of the multicenter lumbar puncture feasibility study
FH. Duits, P. Martinez-Lage, C. Paquet, S. Engelborghs, A. Lleó, L. Hausner, JL. Molinuevo, E. Stomrud, L. Farotti, IH. Ramakers, M. Tsolaki, C. Skarsgård, R. Åstrand, A. Wallin, M. Vyhnalek, M. Holmber-Clausen, OV. Forlenza, L. Ghezzi, M....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, multicentrická studie, práce podpořená grantem
- MeSH
- ambulantní zařízení * MeSH
- bolest hlavy po spinální punkci epidemiologie etiologie MeSH
- demence MeSH
- incidence MeSH
- kognitivní poruchy MeSH
- lidé středního věku MeSH
- lidé MeSH
- paměť fyziologie MeSH
- prospektivní studie MeSH
- rizikové faktory MeSH
- senioři MeSH
- spinální punkce škodlivé účinky metody MeSH
- studie proveditelnosti MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- práce podpořená grantem MeSH
INTRODUCTION: Lumbar puncture (LP) is increasingly performed in memory clinics. We investigated patient-acceptance of LP, incidence of and risk factors for post-LP complications in memory clinic populations. METHODS: We prospectively enrolled 3868 patients (50% women, age 66 ± 11 years, mini mental state examination 25 ± 5) at 23 memory clinics. We used logistic regression analysis using generalized estimated equations to investigate risk factors for post-LP complications, such as typical postlumbar puncture headache (PLPH) and back pain. RESULTS: A total of 1065 patients (31%) reported post-LP complaints; 589 patients (17%) reported back pain, 649 (19%) headache, of which 296 (9%) reported typical PLPH. Only few patients needed medical intervention: 11 (0.3%) received a blood patch, 23 (0.7%) were hospitalized. The most important risk factor for PLPH was medical history of headache. An atraumatic needle and age >65 years were preventive. Gender, rest after LP, or volume of cerebrospinal fluid had no effect. DISCUSSIONS: The overall risk of complications is relatively low. If risk factors shown in this study are taken into account, LPs can be safely performed in memory clinics.
3rd Department of Neurology Aristotle University of Thessaloniki Macedonia Greece
Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas Barcelona Spain
Centro Disturbi della Memoria Clinica Neurologica Università degli Studi di Perugia Perugia Italy
Clinical Memory Research Unit Department of Clinical Sciences Malmö Lund University Lund Sweden
Department of Cognitive Medicine Karlstad Central Hospital Karlstad Sweden
Department of Epidemiology and Biostatistics VU University Medical Center Amsterdam The Netherlands
Department of Geriatrics Minnesmottagningen Eskilstuna Sweden
Department of Molecular Medicine Faculty of Medicine University of Lisbon Lisbon Portugal
Department of Neurology Atrium Medical Center Parkstad Heerlen The Netherlands
Department of Neurology Erasmus MC University Medical Center Rotterdam The Netherlands
Department of Neurology Fundacion CITA Alzheimer Fundazioa San Sebastián Spain
Department of Neurology St Elisabeth Hospital Tilburg The Netherlands
Department of Public Health and Caring Sciences Uppsala University Uppsala Sweden
International Clinical Research Center St Anne's University Hospital Brno Czech Republic
Memory Unit Department of Neurology Hospital de la Santa Creu i Sant Pau Barcelona Spain
Research Memory Center Paris North AP HP Hopital Lariboisière Paris France
The Department of Geriatrics Kalmar County Hospital Kalmar Sweden
UCL Institute of Neurology Department of Molecular Neuroscience London UK
Université Paris Diderot Sorbonne Paris Cité UMRS 942 Paris France
Citace poskytuje Crossref.org
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