• Je něco špatně v tomto záznamu ?

Information transfer through a signaling module with feedback: A perturbative approach

G. Aquino, M. Zapotocky,

. 2015 ; 136 (-) : 66-72. [pub] 20150819

Jazyk angličtina Země Irsko

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc16028287

Signal transduction in biological cells is effected by signaling pathways that typically include multiple feedback loops. Here we analyze information transfer through a prototypical signaling module with biochemical feedback. The module switches stochastically between an inactive and active state; the input to the module governs the activation rate while the output (i.e., the product concentration) perturbs the inactivation rate. Using a novel perturbative approach, we compute the rate with which information about the input is gained from observation of the output. We obtain an explicit analytical result valid to first order in feedback strength and to second order in the strength of input. The total information gained during an extended time interval is found to depend on the feedback strength only through the total number of activation/inactivation events.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc16028287
003      
CZ-PrNML
005      
20161019102140.0
007      
ta
008      
161005s2015 ie f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.biosystems.2015.08.001 $2 doi
024    7_
$a 10.1016/j.biosystems.2015.08.001 $2 doi
035    __
$a (PubMed)26296775
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a ie
100    1_
$a Aquino, Gerardo $u Department of Life Sciences, Imperial College, SW7 2AZ London, UK. Electronic address: g.aquino@imperial.ac.uk. $7 gn_A_00007903
245    10
$a Information transfer through a signaling module with feedback: A perturbative approach / $c G. Aquino, M. Zapotocky,
520    9_
$a Signal transduction in biological cells is effected by signaling pathways that typically include multiple feedback loops. Here we analyze information transfer through a prototypical signaling module with biochemical feedback. The module switches stochastically between an inactive and active state; the input to the module governs the activation rate while the output (i.e., the product concentration) perturbs the inactivation rate. Using a novel perturbative approach, we compute the rate with which information about the input is gained from observation of the output. We obtain an explicit analytical result valid to first order in feedback strength and to second order in the strength of input. The total information gained during an extended time interval is found to depend on the feedback strength only through the total number of activation/inactivation events.
650    _2
$a zvířata $7 D000818
650    _2
$a vápník $x metabolismus $7 D002118
650    _2
$a vápníkové kanály $x metabolismus $7 D015220
650    _2
$a počítačová simulace $7 D003198
650    _2
$a zpětná vazba fyziologická $x fyziologie $7 D025461
650    _2
$a lidé $7 D006801
650    _2
$a ukládání a vyhledávání informací $x metody $7 D016247
650    _2
$a gating iontového kanálu $x fyziologie $7 D015640
650    12
$a biologické modely $7 D008954
650    _2
$a signální transdukce $x fyziologie $7 D015398
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Zapotocky, Martin $u Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic.
773    0_
$w MED00000785 $t Bio Systems $x 1872-8324 $g Roč. 136, č. - (2015), s. 66-72
856    41
$u https://pubmed.ncbi.nlm.nih.gov/26296775 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20161005 $b ABA008
991    __
$a 20161019102545 $b ABA008
999    __
$a ok $b bmc $g 1166601 $s 952917
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2015 $b 136 $c - $d 66-72 $e 20150819 $i 1872-8324 $m Biosystems $n Biosystems $x MED00000785
LZP    __
$a Pubmed-20161005

Najít záznam

Citační ukazatele

Možnosti archivace