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Cubozoan genome illuminates functional diversification of opsins and photoreceptor evolution
M. Liegertová, J. Pergner, I. Kozmiková, P. Fabian, AR. Pombinho, H. Strnad, J. Pačes, Č. Vlček, P. Bartůněk, Z. Kozmik,
Language English Country England, Great Britain
Document type Journal Article
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PubMed
26154478
DOI
10.1038/srep11885
Knihovny.cz E-resources
- MeSH
- Cyclic AMP metabolism MeSH
- Biological Evolution * MeSH
- Cubozoa genetics metabolism MeSH
- Gene Expression MeSH
- Photoreceptor Cells metabolism MeSH
- Phylogeny MeSH
- Genome * MeSH
- Genomics methods MeSH
- Chromosome Mapping MeSH
- RNA, Messenger genetics MeSH
- Multigene Family MeSH
- Opsins genetics metabolism MeSH
- GTP-Binding Proteins metabolism MeSH
- Signal Transduction MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
Animals sense light primarily by an opsin-based photopigment present in a photoreceptor cell. Cnidaria are arguably the most basal phylum containing a well-developed visual system. The evolutionary history of opsins in the animal kingdom has not yet been resolved. Here, we study the evolution of animal opsins by genome-wide analysis of the cubozoan jellyfish Tripedalia cystophora, a cnidarian possessing complex lens-containing eyes and minor photoreceptors. A large number of opsin genes with distinct tissue- and stage-specific expression were identified. Our phylogenetic analysis unequivocally classifies cubozoan opsins as a sister group to c-opsins and documents lineage-specific expansion of the opsin gene repertoire in the cubozoan genome. Functional analyses provided evidence for the use of the Gs-cAMP signaling pathway in a small set of cubozoan opsins, indicating the possibility that the majority of other cubozoan opsins signal via distinct pathways. Additionally, these tests uncovered subtle differences among individual opsins, suggesting possible fine-tuning for specific photoreceptor tasks. Based on phylogenetic, expression and biochemical analysis we propose that rapid lineage- and species-specific duplications of the intron-less opsin genes and their subsequent functional diversification promoted evolution of a large repertoire of both visual and extraocular photoreceptors in cubozoans.
References provided by Crossref.org
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