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The impact of vitamin D deficiency on patients undergoing kidney transplantation: focus on cardiovascular, metabolic, and endocrine outcomes
G. Sarno, G. Daniele, G. Tirabassi, AO. Chavez, OO. Ojo, F. Orio, H. Kahleova, G. Balercia, WB. Grant, P. De Rosa, A. Colao, G. Muscogiuri,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, přehledy
- MeSH
- diabetes mellitus etiologie MeSH
- kardiovaskulární nemoci etiologie MeSH
- kostní denzita MeSH
- lidé MeSH
- nedostatek vitaminu D komplikace farmakoterapie MeSH
- pooperační komplikace etiologie MeSH
- transplantace ledvin * MeSH
- vitamin D aplikace a dávkování MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Vitamin D deficiency is common among kidney transplant (KT) recipients because of reduced sunlight exposure, low intake of vitamin D, the immunosuppressive drug regimen administered, and steroid therapy. Glucocorticoids regulate expression of genes coding for enzymes that catabolize vitamin D, further reducing its level in serum. Although vitamin D primarily regulates calcium homeostasis, vitamin D deficiency is associated with the risk of several diseases, such as diabetes mellitus and tuberculosis. Aim of this review is to highlight endocrine and metabolic alterations due to the vitamin D deficiency by evaluating the mechanisms involved in the development of KT-related disease (cardiovascular, bone mineral density, and new-onset diabetes after transplantation). Next, we review evidence to support a link between low vitamin D status and KT-related diseases. Finally, we briefly highlight strategies for restoring vitamin D status in KT patients.
Institute for Clinical and Experimental Medicine Videnska 1958 9 140 21 Prague Czech Republic
Sunlight Nutrition and Health Research Center San Francisco CA USA
Citace poskytuje Crossref.org
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- $a Sarno, Gerardo $u Department of General Surgery and Transplantation Unit, San Giovanni di Dio e Ruggi D'Aragona University Hospital, Scuola Medica Salernitana, Salerno, Italy.
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- $a Vitamin D deficiency is common among kidney transplant (KT) recipients because of reduced sunlight exposure, low intake of vitamin D, the immunosuppressive drug regimen administered, and steroid therapy. Glucocorticoids regulate expression of genes coding for enzymes that catabolize vitamin D, further reducing its level in serum. Although vitamin D primarily regulates calcium homeostasis, vitamin D deficiency is associated with the risk of several diseases, such as diabetes mellitus and tuberculosis. Aim of this review is to highlight endocrine and metabolic alterations due to the vitamin D deficiency by evaluating the mechanisms involved in the development of KT-related disease (cardiovascular, bone mineral density, and new-onset diabetes after transplantation). Next, we review evidence to support a link between low vitamin D status and KT-related diseases. Finally, we briefly highlight strategies for restoring vitamin D status in KT patients.
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- $a Daniele, Giuseppe $u Divisions of Diabetes and Endocrinology, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
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- $a Tirabassi, Giacomo $u Division of Endocrinology, Department of Clinical and Molecular Sciences, Umberto I Hospital, School of Medicine, Polytechnic University of Marche, Ancona, Italy.
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- $a Chavez, Alberto O $u Divisions of Diabetes and Endocrinology, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
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- $a Ojo, Opeolu O $u Faculty of Life and Health Sciences, School of Biomedical Sciences, University of Ulster, Coleraine, BT52 1SA, UK.
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- $a Orio, Francesco $u Sports Science and Wellness, University Parthenope Naples, Naples, Italy. Endocrinology and Diabetology, San Giovanni di Dio e Ruggi D'Aragona University Hospital, Scuola Medica Salernitana, Salerno, Italy.
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- $a Kahleova, Hana $u Institute for Clinical and Experimental Medicine, Videnska 1958/9, 140 21, Prague, Czech Republic.
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- $a Colao, Annamaria $u Department of Clinical Medicine and Surgery, Federico II University Hospital, Federico II University, Naples, Italy.
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- $a Muscogiuri, Giovanna $u Department of Clinical Medicine and Surgery, Federico II University Hospital, Federico II University, Naples, Italy. giovanna.muscogiuri@gmail.com.
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