• Something wrong with this record ?

Captopril partially decreases the effect of H(2)S on rat blood pressure and inhibits H(2)S-induced nitric oxide release from S-nitrosoglutathione

M. Drobná, A. Misak, T. Holland, F. Kristek, M. Grman, L. Tomasova, A. Berenyiova, S. Cacanyiova, K. Ondrias

. 2015 ; 64 (4) : 479-486. [pub] 20141203

Language English Country Czech Republic

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc16031082

We studied the effects of the H(2)S donor Na(2)S on the mean arterial blood pressure (MAP) and heart and breathing rates of anesthetized Wistar rats in the presence and absence of captopril. Bolus administration of Na(2)S (1-4 micromol/kg) into the right jugular vein transiently decreased heart and increased breathing rates; at 8-30 micromol/kg, Na(2)S had a biphasic effect, transiently decreasing and increasing MAP, while transiently decreasing heart rate and increasing and decreasing breathing rate. These results may indicate independent mechanisms by which H(2)S influences MAP and heart and breathing rates. The effect of Na(2)S in decreasing MAP was less pronounced in the presence of captopril (2 micromol/l), which may indicate that the renin-angiotensin system is partially involved in the Na(2)S effect. Captopril decreased H(2)S-induced NO release from S-nitrosoglutathione, which may be related to some biological activities of H(2)S. These results contribute to the understanding of the effects of H(2)S on the cardiovascular system.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc16031082
003      
CZ-PrNML
005      
20161111143318.0
007      
ta
008      
161102s2015 xr f 000 0|ENG||
009      
AR
024    7_
$a 10.33549/physiolres.932772 $2 doi
035    __
$a (PubMed)25470515
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a ENG
044    __
$a xr
100    1_
$a Drobná, M. $u Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, Bratislava, Slovak Republic
245    10
$a Captopril partially decreases the effect of H(2)S on rat blood pressure and inhibits H(2)S-induced nitric oxide release from S-nitrosoglutathione / $c M. Drobná, A. Misak, T. Holland, F. Kristek, M. Grman, L. Tomasova, A. Berenyiova, S. Cacanyiova, K. Ondrias
520    9_
$a We studied the effects of the H(2)S donor Na(2)S on the mean arterial blood pressure (MAP) and heart and breathing rates of anesthetized Wistar rats in the presence and absence of captopril. Bolus administration of Na(2)S (1-4 micromol/kg) into the right jugular vein transiently decreased heart and increased breathing rates; at 8-30 micromol/kg, Na(2)S had a biphasic effect, transiently decreasing and increasing MAP, while transiently decreasing heart rate and increasing and decreasing breathing rate. These results may indicate independent mechanisms by which H(2)S influences MAP and heart and breathing rates. The effect of Na(2)S in decreasing MAP was less pronounced in the presence of captopril (2 micromol/l), which may indicate that the renin-angiotensin system is partially involved in the Na(2)S effect. Captopril decreased H(2)S-induced NO release from S-nitrosoglutathione, which may be related to some biological activities of H(2)S. These results contribute to the understanding of the effects of H(2)S on the cardiovascular system.
650    _2
$a zvířata $7 D000818
650    _2
$a krevní tlak $x účinky léků $x fyziologie $7 D001794
650    _2
$a kaptopril $x aplikace a dávkování $7 D002216
650    _2
$a vztah mezi dávkou a účinkem léčiva $7 D004305
650    _2
$a antagonismus léků $7 D004336
650    _2
$a lékové interakce $7 D004347
650    _2
$a sulfan $x metabolismus $7 D006862
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a oxid dusnatý $x metabolismus $7 D009569
650    _2
$a krysa rodu Rattus $7 D051381
650    _2
$a potkani Wistar $7 D017208
650    _2
$a dechová frekvence $x fyziologie $x účinky záření $7 D056152
650    _2
$a S-nitrosoglutathion $x metabolismus $7 D026422
650    _2
$a sulfidy $x aplikace a dávkování $7 D013440
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Misak, A. $u Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Bratislava, Slovak Republic
700    1_
$a Holland, T. $u Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Bratislava, Slovak Republic
700    1_
$a Kristek, František $7 xx0259762 $u Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, Bratislava, Slovak Republic
700    1_
$a Grman, M. $u Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Bratislava, Slovak Republic; Center for Molecular Medicine, Slovak Academy of Sciences, Bratislava, Slovak Republic
700    1_
$a Tomášová, L. $7 _AN038930 $u Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Bratislava, Slovak Republic; Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic
700    1_
$a Berényiová, Andrea $7 _AN083191 $u Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, Bratislava, Slovak Republic
700    1_
$a Cacanyiova, S. $u Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, Bratislava, Slovak Republic
700    1_
$a Ondriaš, Karol, $d 1952- $7 _AN033134 $u Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Bratislava, Slovak Republic; Center for Molecular Medicine, Slovak Academy of Sciences, Bratislava, Slovak Republic
773    0_
$w MED00003824 $t Physiological research $x 1802-9973 $g Roč. 64, č. 4 (2015), s. 479-486
856    41
$u http://www.biomed.cas.cz/physiolres/ $y domovská stránka časopisu
910    __
$a ABA008 $b A 4120 $c 266 $y 4 $z 0
990    __
$a 20161102 $b ABA008
991    __
$a 20161109130446 $b ABA008
999    __
$a ok $b bmc $g 1172171 $s 955740
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2015 $b 64 $c 4 $d 479-486 $e 20141203 $i 1802-9973 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
LZP    __
$b NLK118 $a Pubmed-20161102

Find record

Citation metrics

Archiving options