Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Omission of adjuvant radiation therapy in elderly patients with low risk breast cancer undergoing breast-conserving surgery--two center experience

D. Vrana, J. Gatek, L. Lukesova, T. Vazan, B. Melichar, M. Pospiskova, I. Svach,

. 2014 ; 158 (3) : 461-464. [pub] 20130503

Language English Country Czech Republic

Document type Journal Article, Multicenter Study

Persistent link   https://www.medvik.cz/link/bmc16031501

INTRODUCTION: Breast cancer is, now often diagnosed in patients older than 70 years due to longer life expectancy. The usual treatment is mastectomy to obviate radiotherapy or breast-conserving surgery followed by radiotherapy. The aim of this study was to investigate the need for adjuvant radiotherapy in older patients and the consequences of omitting radiotherapy following conservative surgery. METHODS: An extensive database search was made of patients who had been treated for breast cancer at the Department of Oncology, University Hospital Olomouc and the Atlas Hospital in Zlin (2004-2008). We identified 738 patients of whom 190 patients (25.7%) were older than 70 years of age. These were followed up for progression-free and overall survival. The cause of death was checked for breast cancer relapse. RESULTS: In total only 9 patients undergoing breast saving surgery were ultimately identified. No patient had confirmed local recurrence during the follow up period: Two patients have died due to distant metastasis without local relapse and one patient has died for reasons other than breast cancer. CONCLUSION: Omitting radiotherapy after breast saving surgery provides an opportunity for women to undergo breast saving surgery and avoid 7 weeks of radiotherapy. This could significantly improve patient quality of life. In our of many years experience and from published randomized data, this procedure is safe for a select group of patients 70 years of age and older.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc16031501
003      
CZ-PrNML
005      
20161122150808.0
007      
ta
008      
161103s2014 xr f 000 0|ENG||
009      
AR
024    7_
$a 10.5507/bp.2013.032 $2 doi
035    __
$a (PubMed)23681308
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a ENG
044    __
$a xr
100    1_
$a Vrána, David $u Department of Oncology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc; Toxicogenomics Unit, National Institute of Public Health, Prague $7 xx0103187
245    10
$a Omission of adjuvant radiation therapy in elderly patients with low risk breast cancer undergoing breast-conserving surgery--two center experience / $c D. Vrana, J. Gatek, L. Lukesova, T. Vazan, B. Melichar, M. Pospiskova, I. Svach,
520    9_
$a INTRODUCTION: Breast cancer is, now often diagnosed in patients older than 70 years due to longer life expectancy. The usual treatment is mastectomy to obviate radiotherapy or breast-conserving surgery followed by radiotherapy. The aim of this study was to investigate the need for adjuvant radiotherapy in older patients and the consequences of omitting radiotherapy following conservative surgery. METHODS: An extensive database search was made of patients who had been treated for breast cancer at the Department of Oncology, University Hospital Olomouc and the Atlas Hospital in Zlin (2004-2008). We identified 738 patients of whom 190 patients (25.7%) were older than 70 years of age. These were followed up for progression-free and overall survival. The cause of death was checked for breast cancer relapse. RESULTS: In total only 9 patients undergoing breast saving surgery were ultimately identified. No patient had confirmed local recurrence during the follow up period: Two patients have died due to distant metastasis without local relapse and one patient has died for reasons other than breast cancer. CONCLUSION: Omitting radiotherapy after breast saving surgery provides an opportunity for women to undergo breast saving surgery and avoid 7 weeks of radiotherapy. This could significantly improve patient quality of life. In our of many years experience and from published randomized data, this procedure is safe for a select group of patients 70 years of age and older.
650    _2
$a senioři $7 D000368
650    _2
$a senioři nad 80 let $7 D000369
650    _2
$a nádory prsu $x chirurgie $7 D001943
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a segmentální mastektomie $7 D015412
650    _2
$a prognóza $7 D011379
650    _2
$a adjuvantní radioterapie $x využití $7 D018714
650    _2
$a míra přežití $7 D015996
650    _2
$a výsledek terapie $7 D016896
655    _2
$a časopisecké články $7 D016428
655    _2
$a multicentrická studie $7 D016448
700    1_
$a Gatěk, Jiří, $d 1950- $7 xx0052958 $u Department of Surgery, Atlas Hospital, Tomas Bata University in Zlin, Zlin
700    1_
$a Lukešová, Lucie $7 xx0234590 $u Department of Oncology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic
700    1_
$a Vazan, Tomas $u Cytologic and Histopathologic Laboratory, Zlin
700    1_
$a Melichar, Bohuslav, $d 1965- $7 skuk0000853 $u Department of Oncology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic
700    1_
$a Pospíšková, Markéta $7 xx0229118 $u Oncology center, Krajska nemocnice T.Bati a.s., Zlin
700    1_
$a Švach, Ivan $7 xx0033630 $u Department of Surgery I, University Hospital Olomouc
773    0_
$w MED00012606 $t Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czech Republic $x 1213-8118 $g Roč. 158, č. 3 (2014), s. 461-464
856    41
$u http://biomed.papers.upol.cz/ $y domovská stránka časopisu
910    __
$a ABA008 $b A 1502 $c 958 $y 4 $z 0
990    __
$a 20161103 $b ABA008
991    __
$a 20161122150801 $b ABA008
999    __
$a ok $b bmc $g 1173634 $s 956167
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2014 $b 158 $c 3 $d 461-464 $e 20130503 $i 1213-8118 $m Biomedical papers of the Medical Faculty of the University Palacký, Olomouc Czech Republic $n Biomed. Pap. Fac. Med. Palacký Univ. Olomouc Czech Repub. (Print) $x MED00012606
LZP    __
$b NLK118 $a Pubmed-20161103

Find record

Citation metrics

Archiving options