• Je něco špatně v tomto záznamu ?

Non-invasive insight into the release mechanisms of a poorly soluble drug from amorphous solid dispersions by confocal Raman microscopy

K. Punčochová, B. Vukosavljevic, J. Hanuš, J. Beránek, M. Windbergs, F. Štěpánek,

. 2016 ; 101 (-) : 119-25. [pub] 20160206

Jazyk angličtina Země Nizozemsko

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc17000497

In this study, we investigated the release mechanism of the poorly water soluble drug aprepitant from different amorphous solid dispersions using confocal Raman microscopy (CRM). Solid dispersions were fabricated based on either Soluplus®, as an amphiphilic copolymer and solubilizer, or on polyvinylpyrrolidone, as a hydrophilic polymer, in order to elucidate the influence of the polymer characteristics on the drug form and dissolution mechanisms. Aprepitant exhibited its amorphous form in both solid dispersions. However, the release differed depending on the polymer. The high complexation effect of Soluplus was shown to be a crucial factor for stabilization of the amorphous drug, resulting in continuous release without any recrystallization of aprepitant. In contrast, solid dispersions based on polyvinylpyrrolidone showed a different mechanism of dissolution; due to the good affinity of PVP and water, the polymer is dissolving fast, leading to phase separation and local recrystallization of the drug. The study highlights the complexity of release processes from solid dispersions and elucidates the influence of the polymer on drug release kinetics.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc17000497
003      
CZ-PrNML
005      
20170116110519.0
007      
ta
008      
170103s2016 ne f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.ejpb.2016.02.001 $2 doi
024    7_
$a 10.1016/j.ejpb.2016.02.001 $2 doi
035    __
$a (PubMed)26861928
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a ne
100    1_
$a Punčochová, Kateřina $u Department of Chemical Engineering, University of Chemistry and Technology Prague, Prague 6, Czech Republic; Zentiva, k.s., U Kabelovny 130, Prague 10, Czech Republic.
245    10
$a Non-invasive insight into the release mechanisms of a poorly soluble drug from amorphous solid dispersions by confocal Raman microscopy / $c K. Punčochová, B. Vukosavljevic, J. Hanuš, J. Beránek, M. Windbergs, F. Štěpánek,
520    9_
$a In this study, we investigated the release mechanism of the poorly water soluble drug aprepitant from different amorphous solid dispersions using confocal Raman microscopy (CRM). Solid dispersions were fabricated based on either Soluplus®, as an amphiphilic copolymer and solubilizer, or on polyvinylpyrrolidone, as a hydrophilic polymer, in order to elucidate the influence of the polymer characteristics on the drug form and dissolution mechanisms. Aprepitant exhibited its amorphous form in both solid dispersions. However, the release differed depending on the polymer. The high complexation effect of Soluplus was shown to be a crucial factor for stabilization of the amorphous drug, resulting in continuous release without any recrystallization of aprepitant. In contrast, solid dispersions based on polyvinylpyrrolidone showed a different mechanism of dissolution; due to the good affinity of PVP and water, the polymer is dissolving fast, leading to phase separation and local recrystallization of the drug. The study highlights the complexity of release processes from solid dispersions and elucidates the influence of the polymer on drug release kinetics.
650    _2
$a krystalizace $7 D003460
650    _2
$a nosiče léků $x chemie $7 D004337
650    12
$a uvolňování léčiv $7 D065546
650    _2
$a stabilita léku $7 D004355
650    _2
$a hydrofobní a hydrofilní interakce $7 D057927
650    _2
$a kinetika $7 D007700
650    _2
$a konfokální mikroskopie $x metody $7 D018613
650    _2
$a morfoliny $x chemie $7 D009025
650    _2
$a polyethylenglykoly $x chemie $7 D011092
650    _2
$a polymery $x chemie $7 D011108
650    _2
$a polyvinyly $x chemie $7 D011145
650    _2
$a povidon $x chemie $7 D011205
650    _2
$a rozpustnost $7 D012995
650    _2
$a Ramanova spektroskopie $x metody $7 D013059
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Vukosavljevic, Branko $u Department of Biopharmaceutics and Pharmaceutical Technology, Saarland University, Saarbruecken, Germany; Helmholtz Centre for Infection Research (HZI) and Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Department of Drug Delivery, Saarbruecken, Germany.
700    1_
$a Hanuš, Jaroslav $u Department of Chemical Engineering, University of Chemistry and Technology Prague, Prague 6, Czech Republic.
700    1_
$a Beránek, Josef $u Zentiva, k.s., U Kabelovny 130, Prague 10, Czech Republic.
700    1_
$a Windbergs, Maike $u Department of Biopharmaceutics and Pharmaceutical Technology, Saarland University, Saarbruecken, Germany; Helmholtz Centre for Infection Research (HZI) and Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Department of Drug Delivery, Saarbruecken, Germany. Electronic address: m.windbergs@mx.uni-saarland.de.
700    1_
$a Štěpánek, František $u Department of Chemical Engineering, University of Chemistry and Technology Prague, Prague 6, Czech Republic. Electronic address: Frantisek.Stepanek@vscht.cz.
773    0_
$w MED00001640 $t European journal of pharmaceutics and biopharmaceutics official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V $x 1873-3441 $g Roč. 101, č. - (2016), s. 119-25
856    41
$u https://pubmed.ncbi.nlm.nih.gov/26861928 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20170103 $b ABA008
991    __
$a 20170116110624 $b ABA008
999    __
$a ok $b bmc $g 1179637 $s 961064
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2016 $b 101 $c - $d 119-25 $e 20160206 $i 1873-3441 $m European journal of pharmaceutics and biopharmaceutics $n Eur J Pharm Biopharm $x MED00001640
LZP    __
$a Pubmed-20170103

Najít záznam

Citační ukazatele

Možnosti archivace