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Isoquinoline Alkaloids from Fumaria officinalis L. and Their Biological Activities Related to Alzheimer's Disease
J. Chlebek, Z. Novák, D. Kassemová, M. Šafratová, J. Kostelník, L. Malý, M. Ločárek, L. Opletal, A. Hošt'álková, M. Hrabinová, J. Kuneš, P. Novotná, M. Urbanová, L. Nováková, K. Macáková, D. Hulcová, P. Solich, C. Pérez Martín, D. Jun, L. Cahlíková,
Chemistry and biodiversity.
2016 ;
13 (1) :
91-9.
Language English Country Switzerland
Document type Journal Article
Persistent link
https://www.medvik.cz/link/bmc17000648
- MeSH
- Acetylcholinesterase metabolism MeSH
- Alkaloids chemistry isolation & purification pharmacology MeSH
- Alzheimer Disease drug therapy enzymology MeSH
- Butyrylcholinesterase metabolism MeSH
- Fumaria chemistry MeSH
- Enzyme Inhibitors chemistry isolation & purification pharmacology MeSH
- Isoquinolines chemistry isolation & purification pharmacology MeSH
- Glycogen Synthase Kinase 3 antagonists & inhibitors metabolism MeSH
- Humans MeSH
- Molecular Structure MeSH
- Serine Endopeptidases metabolism MeSH
- Dose-Response Relationship, Drug MeSH
- Structure-Activity Relationship MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
Two new isoquinoline alkaloids, named fumaranine (2) and fumarostrejdine (10), along with 18 known alkaloids were isolated from aerial parts of Fumaria officinalis. The structures of the isolated compounds were elucidated on the basis of spectroscopic analyses and by comparison with literature data. The absolute configuration of the new compound 2 was determined by comparing its circular dichroism spectra with those of known analogs. Compounds isolated in sufficient amounts were evaluated for their acetylcholinesterase, butyrylcholinesterase, prolyl oligopeptidase (POP), and glycogen synthase kinase-3β inhibitory activities. Parfumidine (8) and sinactine (15) exhibited potent POP inhibition activities (IC50 99±5 and 53±2 μM, resp.).
References provided by Crossref.org
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