Isoquinoline Alkaloids from Fumaria officinalis L. and Their Biological Activities Related to Alzheimer's Disease
Language English Country Switzerland Media print
Document type Journal Article
- Keywords
- Acetylcholinesterase, Butyrylcholinesterase, Fumaria officinalis, Glycogen synthase kinase-3β, Isoquinoline alkaloids, Prolyl oligopeptidase,
- MeSH
- Acetylcholinesterase metabolism MeSH
- Alkaloids chemistry isolation & purification pharmacology MeSH
- Alzheimer Disease drug therapy enzymology MeSH
- Butyrylcholinesterase metabolism MeSH
- Fumaria chemistry MeSH
- Glycogen Synthase Kinase 3 beta MeSH
- Enzyme Inhibitors chemistry isolation & purification pharmacology MeSH
- Isoquinolines chemistry isolation & purification pharmacology MeSH
- Glycogen Synthase Kinase 3 antagonists & inhibitors metabolism MeSH
- Humans MeSH
- Molecular Structure MeSH
- Prolyl Oligopeptidases MeSH
- Serine Endopeptidases metabolism MeSH
- Dose-Response Relationship, Drug MeSH
- Structure-Activity Relationship MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Acetylcholinesterase MeSH
- Alkaloids MeSH
- Butyrylcholinesterase MeSH
- fumaranine MeSH Browser
- fumarostrejdine MeSH Browser
- GSK3B protein, human MeSH Browser
- Glycogen Synthase Kinase 3 beta MeSH
- Enzyme Inhibitors MeSH
- Isoquinolines MeSH
- Glycogen Synthase Kinase 3 MeSH
- PREPL protein, human MeSH Browser
- Prolyl Oligopeptidases MeSH
- Serine Endopeptidases MeSH
Two new isoquinoline alkaloids, named fumaranine (2) and fumarostrejdine (10), along with 18 known alkaloids were isolated from aerial parts of Fumaria officinalis. The structures of the isolated compounds were elucidated on the basis of spectroscopic analyses and by comparison with literature data. The absolute configuration of the new compound 2 was determined by comparing its circular dichroism spectra with those of known analogs. Compounds isolated in sufficient amounts were evaluated for their acetylcholinesterase, butyrylcholinesterase, prolyl oligopeptidase (POP), and glycogen synthase kinase-3β inhibitory activities. Parfumidine (8) and sinactine (15) exhibited potent POP inhibition activities (IC50 99±5 and 53±2 μM, resp.).
References provided by Crossref.org
Interactions of Isoquinoline Alkaloids with Transition Metals Iron and Copper
Can Isoquinoline Alkaloids Affect Platelet Aggregation in Whole Human Blood?
