Isoquinoline Alkaloids from Fumaria officinalis L. and Their Biological Activities Related to Alzheimer's Disease
Jazyk angličtina Země Švýcarsko Médium print
Typ dokumentu časopisecké články
PubMed
26765356
DOI
10.1002/cbdv.201500033
Knihovny.cz E-zdroje
- Klíčová slova
- Acetylcholinesterase, Butyrylcholinesterase, Fumaria officinalis, Glycogen synthase kinase-3β, Isoquinoline alkaloids, Prolyl oligopeptidase,
- MeSH
- acetylcholinesterasa metabolismus MeSH
- alkaloidy chemie izolace a purifikace farmakologie MeSH
- Alzheimerova nemoc farmakoterapie enzymologie MeSH
- butyrylcholinesterasa metabolismus MeSH
- Fumaria chemie MeSH
- GSK3B MeSH
- inhibitory enzymů chemie izolace a purifikace farmakologie MeSH
- isochinoliny chemie izolace a purifikace farmakologie MeSH
- kinasa 3 glykogensynthasy antagonisté a inhibitory metabolismus MeSH
- lidé MeSH
- molekulární struktura MeSH
- prolyloligopeptidasy MeSH
- serinové endopeptidasy metabolismus MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- vztahy mezi strukturou a aktivitou MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- acetylcholinesterasa MeSH
- alkaloidy MeSH
- butyrylcholinesterasa MeSH
- fumaranine MeSH Prohlížeč
- fumarostrejdine MeSH Prohlížeč
- GSK3B protein, human MeSH Prohlížeč
- GSK3B MeSH
- inhibitory enzymů MeSH
- isochinoliny MeSH
- kinasa 3 glykogensynthasy MeSH
- PREPL protein, human MeSH Prohlížeč
- prolyloligopeptidasy MeSH
- serinové endopeptidasy MeSH
Two new isoquinoline alkaloids, named fumaranine (2) and fumarostrejdine (10), along with 18 known alkaloids were isolated from aerial parts of Fumaria officinalis. The structures of the isolated compounds were elucidated on the basis of spectroscopic analyses and by comparison with literature data. The absolute configuration of the new compound 2 was determined by comparing its circular dichroism spectra with those of known analogs. Compounds isolated in sufficient amounts were evaluated for their acetylcholinesterase, butyrylcholinesterase, prolyl oligopeptidase (POP), and glycogen synthase kinase-3β inhibitory activities. Parfumidine (8) and sinactine (15) exhibited potent POP inhibition activities (IC50 99±5 and 53±2 μM, resp.).
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