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Baicalin loaded in folate-PEG modified liposomes for enhanced stability and tumor targeting
Y. Chen, le V. Minh, J. Liu, B. Angelov, M. Drechsler, VM. Garamus, R. Willumeit-Römer, A. Zou,
Colloids and surfaces. B, Biointerfaces.
2016 ;
140 (-) :
74-82.
[pub] 20151117
Jazyk angličtina Země Nizozemsko
Typ dokumentu časopisecké články, práce podpořená grantem
Perzistentní odkaz
https://www.medvik.cz/link/bmc17000682
- MeSH
- antiflogistika nesteroidní chemie farmakokinetika farmakologie MeSH
- difrakce rentgenového záření MeSH
- elektronová kryomikroskopie MeSH
- flavonoidy chemie farmakokinetika farmakologie MeSH
- folátové receptory zakotvené GPI antagonisté a inhibitory metabolismus MeSH
- HeLa buňky MeSH
- konfokální mikroskopie MeSH
- kyselina listová analogy a deriváty chemie MeSH
- lidé MeSH
- liposomy chemie ultrastruktura MeSH
- maloúhlový rozptyl MeSH
- nádory děložního čípku metabolismus patologie MeSH
- polyethylenglykoly chemie MeSH
- stabilita léku MeSH
- transmisní elektronová mikroskopie MeSH
- uvolňování léčiv MeSH
- viabilita buněk účinky léků MeSH
- Check Tag
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Bioavailability of baicalin (BAI), an example of traditional Chinese medicine, has been modified by loading into liposome. Several liposome systems of different composition i.e., lipid/cholesterol (L), long-circulating stealth liposome (L-PEG) and folate receptor (FR)-targeted liposome (L-FA) have been used as the drug carrier for BAI. The obtained liposomes were around 80 nm in diameter with proper zeta potentials about -25 mV and sufficient physical stability in 3 months. The entrapment efficiency and loading efficiency of BAI in the liposomes were 41.0-46.4% and 8.8-10.0%, respectively. The morphology details of BAI lipsosome systems i.e., formation of small unilamellar vesicles, have been determined by cryogenic transmission electron microscopy (cryo-TEM) and small angle X-ray scattering (SAXS). In vitro cytotoxicity of BAI liposomes against HeLa cells was evaluated by MTT assay. BAI loaded FR-targeted liposomes showed higher cytotoxicity and cellular uptake compared with non-targeted liposomes. The results suggested that L-FA-BAI could enhance anti-tumor efficiency and should be an effective FR-targeted carrier system for BAI delivery.
Citace poskytuje Crossref.org
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