-
Something wrong with this record ?
Soluble receptor for advanced glycation end products and increased aortic stiffness in the general population
O. Mayer, J. Seidlerová, J. Filipovský, P. Vágovičová, P. Wohlfahrt, R. Cífková, J. Windrichová, O. Topolčan,
Language English Country England, Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't
Grant support
NV15-27109A
MZ0
CEP Register
Digital library NLK
Full text - Article
NLK
ProQuest Central
from 2015-01-01 to 1 year ago
Health & Medicine (ProQuest)
from 2015-01-01 to 1 year ago
PubMed
26631850
DOI
10.1038/hr.2015.131
Knihovny.cz E-resources
- MeSH
- Pulse Wave Analysis MeSH
- Aorta physiopathology MeSH
- Adult MeSH
- Blood Pressure physiology MeSH
- Middle Aged MeSH
- Humans MeSH
- Cross-Sectional Studies MeSH
- Receptor for Advanced Glycation End Products blood MeSH
- Aged MeSH
- Vascular Stiffness physiology MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic MeSH
It has been suggested that accumulation of advanced glycation end products (AGEs) is involved in several pathophysiological processes in the vessel wall. We hypothesized that low levels of the soluble receptor for AGEs (sRAGE) might be associated with increased arterial stiffness, a manifestation of vascular ageing in the general population. Using a cross-sectional design, we analyzed 1077 subjects from the Czech post-MONICA study. The aortic pulse wave velocity (aPWV) was measured using a Sphygmocor device. sRAGE concentrations were assessed in frozen samples using enzyme-linked immunosorbent assay methods (R&D Systems). aPWV significantly (P<0.0001) increased across the sRAGE quartiles. An aPWV of 1 m s(-1) was associated with a 37% increase in the risk of low sRAGE (<918 pg ml(-1), bottom quartile; P-value=0.018). In a categorized manner, subjects in the bottom sRAGE quartile had an odds ratio of an increased aPWV (⩾9.3 m s(-1)), adjusted for all potential confounders of 2.05 (95% confidence interval: 1.26-3.32; P=0.004), but this was only the case for non-diabetic hypertensive patients. In contrast, a low sRAGE was rejected as an independent predictor of an increased aPWV in normotensive or diabetic subjects using similar regression models. In conclusion, low circulating sRAGE was independently associated with increased arterial stiffness in a general population-based sample, but this was only observed in hypertensive non-diabetic patients.
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc17000819
- 003
- CZ-PrNML
- 005
- 20170118083539.0
- 007
- ta
- 008
- 170103s2016 enk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1038/hr.2015.131 $2 doi
- 024 7_
- $a 10.1038/hr.2015.131 $2 doi
- 035 __
- $a (PubMed)26631850
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a enk
- 100 1_
- $a Mayer, Otto $u Second Department of Internal Medicine, Medical Faculty of Charles University and University Hospital, Pilsen, Czech Republic. Biomedical Center, Medical Faculty of Charles University, Pilsen, Czech Republic.
- 245 10
- $a Soluble receptor for advanced glycation end products and increased aortic stiffness in the general population / $c O. Mayer, J. Seidlerová, J. Filipovský, P. Vágovičová, P. Wohlfahrt, R. Cífková, J. Windrichová, O. Topolčan,
- 520 9_
- $a It has been suggested that accumulation of advanced glycation end products (AGEs) is involved in several pathophysiological processes in the vessel wall. We hypothesized that low levels of the soluble receptor for AGEs (sRAGE) might be associated with increased arterial stiffness, a manifestation of vascular ageing in the general population. Using a cross-sectional design, we analyzed 1077 subjects from the Czech post-MONICA study. The aortic pulse wave velocity (aPWV) was measured using a Sphygmocor device. sRAGE concentrations were assessed in frozen samples using enzyme-linked immunosorbent assay methods (R&D Systems). aPWV significantly (P<0.0001) increased across the sRAGE quartiles. An aPWV of 1 m s(-1) was associated with a 37% increase in the risk of low sRAGE (<918 pg ml(-1), bottom quartile; P-value=0.018). In a categorized manner, subjects in the bottom sRAGE quartile had an odds ratio of an increased aPWV (⩾9.3 m s(-1)), adjusted for all potential confounders of 2.05 (95% confidence interval: 1.26-3.32; P=0.004), but this was only the case for non-diabetic hypertensive patients. In contrast, a low sRAGE was rejected as an independent predictor of an increased aPWV in normotensive or diabetic subjects using similar regression models. In conclusion, low circulating sRAGE was independently associated with increased arterial stiffness in a general population-based sample, but this was only observed in hypertensive non-diabetic patients.
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a receptor pro konečné produkty pokročilé glykace $x krev $7 D000067759
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a aorta $x patofyziologie $7 D001011
- 650 _2
- $a krevní tlak $x fyziologie $7 D001794
- 650 _2
- $a průřezové studie $7 D003430
- 650 _2
- $a Česká republika $7 D018153
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a analýza pulzové vlny $7 D063177
- 650 _2
- $a tuhost cévní stěny $x fyziologie $7 D059289
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Seidlerová, Jitka $u Second Department of Internal Medicine, Medical Faculty of Charles University and University Hospital, Pilsen, Czech Republic. Biomedical Center, Medical Faculty of Charles University, Pilsen, Czech Republic.
- 700 1_
- $a Filipovský, Jan $u Second Department of Internal Medicine, Medical Faculty of Charles University and University Hospital, Pilsen, Czech Republic. Biomedical Center, Medical Faculty of Charles University, Pilsen, Czech Republic.
- 700 1_
- $a Vágovičová, Petra $u Second Department of Internal Medicine, Medical Faculty of Charles University and University Hospital, Pilsen, Czech Republic. Biomedical Center, Medical Faculty of Charles University, Pilsen, Czech Republic.
- 700 1_
- $a Wohlfahrt, Peter $u Centre for Cardiovascular Prevention of the First Faculty of Medicine, Charles University and Thomayer Hospital, Prague, Czech Republic. International Clinical Research Centre, St Anne's University Hospital, Brno, Czech Republic.
- 700 1_
- $a Cífková, Renata $u Centre for Cardiovascular Prevention of the First Faculty of Medicine, Charles University and Thomayer Hospital, Prague, Czech Republic. International Clinical Research Centre, St Anne's University Hospital, Brno, Czech Republic.
- 700 1_
- $a Windrichová, Jindra $u Department of Immunodiagnostics, University Hospital, Pilsen, Czech Republic. $7 xx0209887
- 700 1_
- $a Topolčan, Ondřej $u Department of Immunodiagnostics, University Hospital, Pilsen, Czech Republic. Czech Republic of Clinical Biochemistry and Hematology, University Hospital, Pilsen, Czech Republic.
- 773 0_
- $w MED00006041 $t Hypertension research official journal of the Japanese Society of Hypertension $x 1348-4214 $g Roč. 39, č. 4 (2016), s. 266-71
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/26631850 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20170103 $b ABA008
- 991 __
- $a 20170118083646 $b ABA008
- 999 __
- $a ok $b bmc $g 1179959 $s 961386
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2016 $b 39 $c 4 $d 266-71 $e 20151203 $i 1348-4214 $m Hypertension research $n Hypertens Res $x MED00006041
- GRA __
- $a NV15-27109A $p MZ0
- LZP __
- $a Pubmed-20170103
