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Orthostatic hypotension in diabetic patients-10-year follow-up study
L. Gaspar, P. Kruzliak, A. Komornikova, Z. Celecova, B. Krahulec, D. Balaz, P. Sabaka, M. Caprnda, M. Kucera, L. Rodrigo, Y. Uehara, A. Dukat,
Language English Country United States
Document type Journal Article
NLK
ProQuest Central
from 2003-01-01 to 2 months ago
Medline Complete (EBSCOhost)
from 2012-09-01 to 2015-07-31
Nursing & Allied Health Database (ProQuest)
from 2003-01-01 to 2 months ago
Health & Medicine (ProQuest)
from 2003-01-01 to 2 months ago
Family Health Database (ProQuest)
from 2003-01-01 to 2 months ago
- MeSH
- Outpatient Clinics, Hospital MeSH
- Diabetes Mellitus, Type 1 complications MeSH
- Diabetes Mellitus, Type 2 complications MeSH
- Diabetic Cardiomyopathies complications epidemiology mortality physiopathology MeSH
- Diabetic Angiopathies complications epidemiology mortality physiopathology MeSH
- Diabetic Nephropathies complications epidemiology mortality physiopathology MeSH
- Diabetic Neuropathies complications epidemiology mortality physiopathology MeSH
- Adult MeSH
- Cardiovascular Diseases complications epidemiology mortality physiopathology MeSH
- Cohort Studies MeSH
- Middle Aged MeSH
- Humans MeSH
- Mortality MeSH
- Follow-Up Studies MeSH
- Hospitals, University MeSH
- Hypotension, Orthostatic complications epidemiology mortality physiopathology MeSH
- Prevalence MeSH
- Renal Insufficiency complications epidemiology mortality physiopathology MeSH
- Retrospective Studies MeSH
- Risk Factors MeSH
- Severity of Illness Index MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Publication type
- Journal Article MeSH
- Geographicals
- Slovakia epidemiology MeSH
INTRODUCTION: Cardiovascular autonomic neuropathy in diabetics is a common but often underestimated and underdiagnosed complication of diabetes mellitus. One of the most clinical apparent forms of cardiovascular autonomic neuropathy is orthostatic hypotension. OBJECTIVES: To retrospectively assess the association of the orthostatic hypotension (OH) with macrovascular and microvascular complications of diabetes mellitus and to determine its effect on mortality. DESIGN AND METHODS: We retrospectively analyzed 187 patients with diabetes mellitus (60 patients with diabetes type 1 and 127 patients with diabetes type 2). Patients were divided into groups according to presence or absence of OH and type of diabetes. Association of OH with macrovascular and microvascular complications was evaluated and the effect of OH on 10-year all-cause mortality was also assessed. RESULTS: OH was present in 31.7% of patients with diabetes type 1 (DM1) and in 32.3% of patients with diabetes type 2 (DM2). OH was positively associated with the prevalence of myocardial infarction in DM1 (OR=10.67) and with prevalence of stroke in DM2 (OR=3.33). There was also a strong association of OH and the prevalence of peripheral artery disease in both DM1 (OR=14.18) and DM2 (OR=3.26). Patients with both types of diabetes and OH had significantly higher prevalence of nephropathy (DM1 OR=8.68, DM2 OR=3.24), retinopathy (DM1 OR=8.09, DM2 OR=4.08) and peripheral neuropathy (DM1 OR=17.14, DM2 OR=7.51) Overall 10year mortality rate was higher in diabetic patients with OH. CONCLUSIONS: Presence of OH in diabetics is associated with higher prevalence of macrovascular and microvascular complications of diabetes mellitus and also with higher 10-year mortality.
Department of Gastroenterology Central University Hospital of Asturias Oviedo Spain
Division of Clinical Nutrition Faculty of Home Economics Kyoritsu Women's University Tokyo Japan
References provided by Crossref.org
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- $a Gaspar, Ludovit $u 2(nd) Department of Internal Medicine, Comenius University and University Hospital, Bratislava, Slovak Republic. Electronic address: ludovitgaspar@gmail.com.
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- $a INTRODUCTION: Cardiovascular autonomic neuropathy in diabetics is a common but often underestimated and underdiagnosed complication of diabetes mellitus. One of the most clinical apparent forms of cardiovascular autonomic neuropathy is orthostatic hypotension. OBJECTIVES: To retrospectively assess the association of the orthostatic hypotension (OH) with macrovascular and microvascular complications of diabetes mellitus and to determine its effect on mortality. DESIGN AND METHODS: We retrospectively analyzed 187 patients with diabetes mellitus (60 patients with diabetes type 1 and 127 patients with diabetes type 2). Patients were divided into groups according to presence or absence of OH and type of diabetes. Association of OH with macrovascular and microvascular complications was evaluated and the effect of OH on 10-year all-cause mortality was also assessed. RESULTS: OH was present in 31.7% of patients with diabetes type 1 (DM1) and in 32.3% of patients with diabetes type 2 (DM2). OH was positively associated with the prevalence of myocardial infarction in DM1 (OR=10.67) and with prevalence of stroke in DM2 (OR=3.33). There was also a strong association of OH and the prevalence of peripheral artery disease in both DM1 (OR=14.18) and DM2 (OR=3.26). Patients with both types of diabetes and OH had significantly higher prevalence of nephropathy (DM1 OR=8.68, DM2 OR=3.24), retinopathy (DM1 OR=8.09, DM2 OR=4.08) and peripheral neuropathy (DM1 OR=17.14, DM2 OR=7.51) Overall 10year mortality rate was higher in diabetic patients with OH. CONCLUSIONS: Presence of OH in diabetics is associated with higher prevalence of macrovascular and microvascular complications of diabetes mellitus and also with higher 10-year mortality.
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