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Increasing DNA reactivity and in vitro antitumor activity of trans diiodido Pt(II) complexes with UVA light
F. Navas, S. Perfahl, C. Garino, L. Salassa, O. Novakova, C. Navarro-Ranninger, PJ. Bednarski, J. Malina, AG. Quiroga,
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- DNA chemistry MeSH
- Iodides chemistry MeSH
- Humans MeSH
- Cell Line, Tumor MeSH
- Organoplatinum Compounds chemistry radiation effects toxicity MeSH
- Antineoplastic Agents chemistry radiation effects toxicity MeSH
- Ultraviolet Rays * MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Trans diiodido platinum(II) complexes bearing the same as well as different aliphatic amines (mixed-amines) have interesting biological activity; cytotoxicity and interactions with some important biological models have already been demonstrated. Herein we described the interaction of such compounds with ct-DNA, supercoiled and linearized plasmid DNA and 5-GMP. Interestingly, UV irradiation of these compounds results in an increase in reactivity towards DNA and 5-GMP in such model systems. Additionally, the cytotoxicity of the trans-Pt(II) complexes towards human cancer cells is noticeably increased when treatment is combined for 90min with UVA-irradiation. With this work we provide evidence that trans diiodido compounds can be activated by UV-light over relatively short treatment times.
References provided by Crossref.org
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