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Neutrophils influx and proinflammatory cytokines inhibition by sodium salicylate, unlike aspirin, in Candida albicans-induced peritonitis model
PA. Pereira, D. Bini, F. Bovo, LH. Faccioli, MC. Monteiro,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
- MeSH
- antiflogistika nesteroidní aplikace a dávkování MeSH
- Aspirin aplikace a dávkování MeSH
- cytokiny sekrece MeSH
- kandidóza patologie MeSH
- modely nemocí na zvířatech MeSH
- myši inbrední BALB C MeSH
- neutrofily imunologie MeSH
- peritonitida patologie MeSH
- salicylan sodný aplikace a dávkování MeSH
- zvířata MeSH
- Check Tag
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
Sodium salicylate (NaS) and aspirin (ASA) are known to have a variety of effects on microorganisms, such as fungus (C. albicans and C. neoformans), moreover, it have effects in leukocyte adhesion and migration in vitro. In this report, we investigated the effect of ASA and NaS in neutrophil migration and cytokine production in C. albicans-induced peritonitis murine model. For this, mice were treated intraperitoneally (i.p) or orally (po) with NaS or ASA; after they were stimulated i.p. with C. albicans, the cellular migration was evaluated 24 h after stimulation. NaS, in mice treated i.p., unlike ASA, was able to inhibit the neutrophil migration and proinflammatory cytokine production induced by C. albicans, such as TNF-α, IL-1, IFN-γ, IL-12, and IL-10, but did not alter the IL-4 levels in these animals. However, the po treatment with same the dose of NaS or ASA did not affect the influx of this cell for inflammatory site. These results suggest that the NaS inhibits cellular migration and proinflammatory cytokine by different anti-inflammatory mechanism compared to ASA.
Departamento de Anatomia Patológica Universidade Federal do Paraná PR Paraná Brazil
Departamento de Biologia Universidade Estadual do Centro Oeste UNICENTRO Guarapuava PR Brazil
Citace poskytuje Crossref.org
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- $a Sodium salicylate (NaS) and aspirin (ASA) are known to have a variety of effects on microorganisms, such as fungus (C. albicans and C. neoformans), moreover, it have effects in leukocyte adhesion and migration in vitro. In this report, we investigated the effect of ASA and NaS in neutrophil migration and cytokine production in C. albicans-induced peritonitis murine model. For this, mice were treated intraperitoneally (i.p) or orally (po) with NaS or ASA; after they were stimulated i.p. with C. albicans, the cellular migration was evaluated 24 h after stimulation. NaS, in mice treated i.p., unlike ASA, was able to inhibit the neutrophil migration and proinflammatory cytokine production induced by C. albicans, such as TNF-α, IL-1, IFN-γ, IL-12, and IL-10, but did not alter the IL-4 levels in these animals. However, the po treatment with same the dose of NaS or ASA did not affect the influx of this cell for inflammatory site. These results suggest that the NaS inhibits cellular migration and proinflammatory cytokine by different anti-inflammatory mechanism compared to ASA.
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- $a Monteiro, Marta Chagas $u Pós-graduação em Ciências Farmacêuticas, Pós-graduação em Neurociências e Biologia celular, Faculdade de Farmácia, Instituto de Ciências da Saúde, Universidade Federal do Pará/UFPA, Rua Augusto Correia, Belém, PA, Brazil. martachagas2@yahoo.com.br. Endereço: Laboratório de Microbiologia e Imunologia Clínica, Faculdade de Farmácia, Instituto de Ciências da Saúde, Universidade Federal do Pará/UFPA, Rua Augusto Correia, Belém, PA, Brazil. martachagas2@yahoo.com.br.
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