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Diabetes converts arterial regulation by perivascular adipose tissue from relaxation into H(2)O(2)-mediated contraction

R. Emilova, D. Z. Dimitrova, M. Mladenov, N. Hadzi-Petrushev, T. Daneva, P. Padeshki, R. Schubert, M. Chichova, L. Lubomirov, D. Simeonovska-Nikolova, H. Gagov

. 2016 ; 65 (5) : 799-807. [pub] 20160715

Language English Country Czech Republic

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc17012774

This study aims to reveal the reason for the increased force of 5-hydroxytryptamine-induced contraction of endothelium-denuded skeletal muscle arteries of diabetic rats in the presence of perivascular adipose tissue (PVAT). Our data on rat gracilis arteries show that i) PVAT of skeletal muscle arteries of healthy and diabetic rats releases hydrogen peroxide (H(2)O(2)), ii) higher concentrations of 5-hydroxytryptamine increase the production of H(2)O(2) in PVAT; iii) an enhanced PVAT production of H(2)O(2) is the main, if not the only, reason for the sensitization of arterial contraction to 5-hydroxytriptamine-induced contraction in diabetes and iv) endothelium antagonizes the effect of PVAT-derived H(2)O(2).

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$a Mladenov, M. $u University of Skopje Sts. Cyril and Methodius, Faculty of Natural Sciences and Mathematics, Institute of Biology, Skopje, Macedonia
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$a Hadzi-Petrushev, N. $u University of Skopje Sts. Cyril and Methodius, Faculty of Natural Sciences and Mathematics, Institute of Biology, Skopje, Macedonia
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$a Daneva, T. $u Bulgarian Academy of Sciences, Institute of Biology and Immunology of Reproduction, Sofia, Bulgaria
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$a Padeshki, P. $u National Center of Infectious and Parasitic Diseases, Sofia, Bulgaria
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$a Schubert, R. $u Ruprecht-Karls-University Heidelberg, Medical Faculty Mannheim, Department of Cardiovascular Physiology, Mannheim, Germany
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$a Lubomirov, L. $u Institute of Vegetative Physiology, University of Cologne, Germany
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