Diabetes converts arterial regulation by perivascular adipose tissue from relaxation into H(2)O(2)-mediated contraction
Language English Country Czech Republic Media print-electronic
Document type Journal Article
PubMed
27429118
DOI
10.33549/physiolres.933037
PII: 933037
Knihovny.cz E-resources
- MeSH
- Arteries physiopathology MeSH
- Diabetes Mellitus, Experimental metabolism physiopathology MeSH
- Muscle, Skeletal blood supply MeSH
- Hydrogen Peroxide metabolism MeSH
- Rats, Wistar MeSH
- Serotonin MeSH
- Adipose Tissue metabolism MeSH
- Vasoconstriction * MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Hydrogen Peroxide MeSH
- Serotonin MeSH
This study aims to reveal the reason for the increased force of 5-hydroxytryptamine-induced contraction of endothelium-denuded skeletal muscle arteries of diabetic rats in the presence of perivascular adipose tissue (PVAT). Our data on rat gracilis arteries show that i) PVAT of skeletal muscle arteries of healthy and diabetic rats releases hydrogen peroxide (H(2)O(2)), ii) higher concentrations of 5-hydroxytryptamine increase the production of H(2)O(2) in PVAT; iii) an enhanced PVAT production of H(2)O(2) is the main, if not the only, reason for the sensitization of arterial contraction to 5-hydroxytriptamine-induced contraction in diabetes and iv) endothelium antagonizes the effect of PVAT-derived H(2)O(2).
References provided by Crossref.org
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