Diabetes converts arterial regulation by perivascular adipose tissue from relaxation into H(2)O(2)-mediated contraction
Jazyk angličtina Země Česko Médium print-electronic
Typ dokumentu časopisecké články
PubMed
27429118
DOI
10.33549/physiolres.933037
PII: 933037
Knihovny.cz E-zdroje
- MeSH
- arterie patofyziologie MeSH
- experimentální diabetes mellitus metabolismus patofyziologie MeSH
- kosterní svaly krevní zásobení MeSH
- peroxid vodíku metabolismus MeSH
- potkani Wistar MeSH
- serotonin MeSH
- tuková tkáň metabolismus MeSH
- vazokonstrikce * MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- peroxid vodíku MeSH
- serotonin MeSH
This study aims to reveal the reason for the increased force of 5-hydroxytryptamine-induced contraction of endothelium-denuded skeletal muscle arteries of diabetic rats in the presence of perivascular adipose tissue (PVAT). Our data on rat gracilis arteries show that i) PVAT of skeletal muscle arteries of healthy and diabetic rats releases hydrogen peroxide (H(2)O(2)), ii) higher concentrations of 5-hydroxytryptamine increase the production of H(2)O(2) in PVAT; iii) an enhanced PVAT production of H(2)O(2) is the main, if not the only, reason for the sensitization of arterial contraction to 5-hydroxytriptamine-induced contraction in diabetes and iv) endothelium antagonizes the effect of PVAT-derived H(2)O(2).
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