Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Beneficial effect of continuous normobaric hypoxia on ventricular dilatation in rats with post-infarction heart failure

J. Hrdlička, J. Neckář, F. Papoušek, J. Vašinová, P. Alánová, F. Kolář

. 2016 ; 65 (5) : 867-870. [pub] 20160715

Jazyk angličtina Země Česko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc17012778

Grantová podpora
NV15-27735A MZ0 CEP - Centrální evidence projektů

Adaptation to continuous normobaric hypoxia (CNH) protects the heart against ischemia/reperfusion injury but much less is known about its potential therapeutic effects. The aim of this study was to find out whether post-infarction exposure to CNH can attenuate the progression of heart failure. Ten-week-old male rats underwent myocardial infarction (MI) or sham operation. MI was induced by 60-min coronary artery occlusion. Seven days post-MI, the rats were randomly assigned to two groups: i) sedentary controls kept at room air and ii) rats exposed to CNH (12 % O(2), 3 weeks). Echocardiographic examination of the left ventricle (LV) was performed 3 days before surgery and 7, 14 and 28 days post-MI. MI resulted in a gradual increase in LV end-diastolic diameter (LVD(d)) compared to sham-operated animals. Fractional shortening (FS) decreased from 42.8 % before MI to 15.1 % on day 28 post-MI. CNH significantly attenuated ventricular dilatation without affecting scar area and FS. Our data suggest that prolonged exposure to CNH has certain potential to attenuate the progression of unfavorable changes in ventricular geometry induced by MI in rats.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc17012778
003      
CZ-PrNML
005      
20170425105015.0
007      
ta
008      
170412s2016 xr ad f 000 0|eng||
009      
AR
024    7_
$a 10.33549/physiolres.933308 $2 doi
035    __
$a (PubMed)27429114
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Hrdlička, J. $u Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic; Department of Physiology, Faculty of Science, Charles University in Prague, Prague, Czech Republic $7 xx0272235
245    10
$a Beneficial effect of continuous normobaric hypoxia on ventricular dilatation in rats with post-infarction heart failure / $c J. Hrdlička, J. Neckář, F. Papoušek, J. Vašinová, P. Alánová, F. Kolář
520    9_
$a Adaptation to continuous normobaric hypoxia (CNH) protects the heart against ischemia/reperfusion injury but much less is known about its potential therapeutic effects. The aim of this study was to find out whether post-infarction exposure to CNH can attenuate the progression of heart failure. Ten-week-old male rats underwent myocardial infarction (MI) or sham operation. MI was induced by 60-min coronary artery occlusion. Seven days post-MI, the rats were randomly assigned to two groups: i) sedentary controls kept at room air and ii) rats exposed to CNH (12 % O(2), 3 weeks). Echocardiographic examination of the left ventricle (LV) was performed 3 days before surgery and 7, 14 and 28 days post-MI. MI resulted in a gradual increase in LV end-diastolic diameter (LVD(d)) compared to sham-operated animals. Fractional shortening (FS) decreased from 42.8 % before MI to 15.1 % on day 28 post-MI. CNH significantly attenuated ventricular dilatation without affecting scar area and FS. Our data suggest that prolonged exposure to CNH has certain potential to attenuate the progression of unfavorable changes in ventricular geometry induced by MI in rats.
650    _2
$a zvířata $7 D000818
650    _2
$a srdeční selhání $x etiologie $x prevence a kontrola $7 D006333
650    12
$a hypoxie $7 D000860
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a infarkt myokardu $x komplikace $x terapie $7 D009203
650    _2
$a reperfuzní poškození myokardu $x komplikace $x terapie $7 D015428
650    _2
$a náhodné rozdělení $7 D011897
650    _2
$a potkani Wistar $7 D017208
650    12
$a remodelace komor $7 D020257
655    _2
$a časopisecké články $7 D016428
700    1_
$a Neckář, Jan, $d 1973- $7 xx0074182 $u Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
700    1_
$a Papoušek, František, $d 1948- $7 xx0074150 $u Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
700    1_
$a Vašinová, J. $7 _AN091318 $u Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
700    1_
$a Alánová, P. $7 _AN089208 $u Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
700    1_
$a Kolář, František, $d 1952 říjen 2.- $7 xx0037264 $u Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
773    0_
$w MED00003824 $t Physiological research $x 1802-9973 $g Roč. 65, č. 5 (2016), s. 867-870
856    41
$u http://www.biomed.cas.cz/physiolres/ $y domovská stránka časopisu
910    __
$a ABA008 $b A 4120 $c 266 $y 4 $z 0
990    __
$a 20170412 $b ABA008
991    __
$a 20170425083124 $b ABA008
999    __
$a ok $b bmc $g 1201956 $s 973551
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2016 $b 65 $c 5 $d 867-870 $e 20160715 $i 1802-9973 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
GRA    __
$a NV15-27735A $p MZ0
LZP    __
$b NLK118 $a Pubmed-20170412

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace