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Perspectives and challenges of antioxidant therapy for atrial fibrillation
I. Gasparova, P. Kubatka, R. Opatrilova, M. Caprnda, S. Filipova, L. Rodrigo, L. Malan, I. Mozos, M. Rabajdova, V. Nosal, N. Kobyliak, V. Valentova, D. Petrovic, M. Adamek, P. Kruzliak,
Jazyk angličtina Země Německo
Typ dokumentu časopisecké články, přehledy
NLK
ProQuest Central
od 2013-01-01 do Před 1 rokem
Medline Complete (EBSCOhost)
od 2000-01-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 2013-01-01 do Před 1 rokem
- MeSH
- akční potenciály MeSH
- antiarytmika farmakologie MeSH
- antioxidancia terapeutické užití MeSH
- fibrilace síní farmakoterapie genetika metabolismus patofyziologie MeSH
- genetická terapie metody MeSH
- lidé MeSH
- oxidační stres účinky léků genetika MeSH
- remodelace síní účinky léků MeSH
- rizikové faktory MeSH
- srdeční frekvence účinky léků MeSH
- srdeční síně účinky léků metabolismus patofyziologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Atrial fibrillation (AF) is the most common sustained arrhythmia associated with significant morbidity and mortality. The mechanisms underlying the pathogenesis of AF are poorly understood, although electrophysiological remodeling has been described as an important initiating step. There is growing evidence that oxidative stress is involved in the pathogenesis of AF. Many known triggers of oxidative stress, such as age, diabetes, smoking, and inflammation, are linked with an increased risk of arrhythmia. Numerous preclinical studies and clinical trials reported the importance of antioxidant therapy in the prevention of AF, using vitamins C and E, polyunsaturated fatty acids, statins, or nitric oxide donors. The aim of our work is to give a current overview and analysis of opportunities, challenges, and benefits of antioxidant therapy in AF.
2nd Department of Internal Medicine Faculty of Medicine Comenius University Bratislava Slovakia
Department of Cardiology National Institute of Cardiovascular Diseases Bratislava Slovakia
Department of Endocrinology Bogomolets National Medical University Kyiv Ukraine
Department of Functional Sciences Victor Babes University of Medicine and Pharmacy Timisoara Romania
Department of Thoracic Surgery Medical University of Silesia Zabrze Poland
Faculty of Medicine University of Oviedo Central University of Asturias Oviedo Spain
Institute of Histology and Embryology Faculty of Medicine University of Ljublana Ljublana Slovenia
Citace poskytuje Crossref.org
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- $a Gasparova, Iveta $u Institute of Biology, Genetics and Medical Genetics, Faculty of Medicine, Comenius University and University Hospital, Bratislava, Slovak Republic, Slovakia.
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- $a Atrial fibrillation (AF) is the most common sustained arrhythmia associated with significant morbidity and mortality. The mechanisms underlying the pathogenesis of AF are poorly understood, although electrophysiological remodeling has been described as an important initiating step. There is growing evidence that oxidative stress is involved in the pathogenesis of AF. Many known triggers of oxidative stress, such as age, diabetes, smoking, and inflammation, are linked with an increased risk of arrhythmia. Numerous preclinical studies and clinical trials reported the importance of antioxidant therapy in the prevention of AF, using vitamins C and E, polyunsaturated fatty acids, statins, or nitric oxide donors. The aim of our work is to give a current overview and analysis of opportunities, challenges, and benefits of antioxidant therapy in AF.
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- $a Kubatka, Peter $u Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovak Republic, Slovakia.
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- $a Kruzliak, Peter $u Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic. kruzliakpeter@gmail.com. 2nd Department of Surgery, Faculty of Medicine, Masaryk University, Brno, Czech Republic. kruzliakpeter@gmail.com.
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