• Something wrong with this record ?

Can morphological MRI differentiate between primary central nervous system lymphoma and glioblastoma

H. Malikova, E. Koubska, J. Weichet, J. Klener, A. Rulseh, R. Liscak, Z. Vojtech,

. 2016 ; 16 (1) : 40. [pub] 20161129

Language English Country England, Great Britain

Document type Evaluation Study, Journal Article

Persistent link   https://www.medvik.cz/link/bmc17013371

BACKGROUND: Primary central nervous system lymphoma (PCNSL) is a rare, aggressive brain neoplasm that accounts for roughly 2-6% of primary brain tumors. In contrast, glioblastoma (GBM) is the most frequent and severe glioma subtype, accounting for approximately 50% of diffuse gliomas. The aim of the present study was to evaluate morphological MRI characteristics in histologically-proven PCNSL and GBM at the time of their initial presentation. METHODS: We retrospectively evaluated standard diagnostic MRI examinations in 54 immunocompetent patients (26 female, 28 male; age 62.6 ± 11.5 years) with histologically-proven PCNSL and 54 GBM subjects (21 female, 33 male; age 59 ± 14 years). RESULTS: Several significant differences between both infiltrative brain tumors were found. PCNSL lesions enhanced homogenously in 64.8% of cases, while nonhomogeneous enhancement was observed in 98.1% of GBM cases. Necrosis was present in 88.9% of GBM lesions and only 5.6% of PCNSL lesions. PCNSL presented as multiple lesions in 51.9% cases and in 35.2% of GBM cases; however, diffuse infiltrative type of brain involvement was observed only in PCNSL (24.1%). Optic pathways were infiltrated more commonly in PCNSL than in GBM (42.6% vs. 5.6%, respectively, p <0.001). Other cranial nerves were affected in 5.6% of PCNSL, and in none of GBM. Signs of bleeding were rare in PCNSL (5.6%) and common in GBM (44.4%); p < 0.001. Both supratentorial and infratentorial localization was present only in PCNSL (27.7%). Involvement of the basal ganglia was more common in PCNSL (55.6%) than in GBM (18.5%); (p < 0.001). Cerebral cortex was affected significantly more often in GBM (83.3%) than in PCNSL (51.9%); mostly by both enhancing and non-enhancing infiltration. CONCLUSION: Routine morphological MRI is capable of differentiating between GBM and PCNSL lesions in many cases at time of initial presentation. A solitary infiltrative supratentorial lesion with nonhomogeneous enhancement and necrosis was typical for GBM. PCNSL presented with multiple lesions that enhanced homogenously or as diffuse infiltrative type of brain involvement, often with basal ganglia and optic pathways affection.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc17013371
003      
CZ-PrNML
005      
20200131105348.0
007      
ta
008      
170413s2016 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1186/s40644-016-0098-9 $2 doi
035    __
$a (PubMed)27894359
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Malikova, H $u Department of Radiology, Na Homolce Hospital, Roentgenova 2, Prague, 15000, Czech Republic. hanamalikova123@gmail.com. Department of Radiology, Third Faculty of Medicine, Charles University in Prague and Faculty Hospital Kralovske Vinohrady, Ruska 87, Prague, 10000, Czech Republic. hanamalikova123@gmail.com.
245    10
$a Can morphological MRI differentiate between primary central nervous system lymphoma and glioblastoma / $c H. Malikova, E. Koubska, J. Weichet, J. Klener, A. Rulseh, R. Liscak, Z. Vojtech,
520    9_
$a BACKGROUND: Primary central nervous system lymphoma (PCNSL) is a rare, aggressive brain neoplasm that accounts for roughly 2-6% of primary brain tumors. In contrast, glioblastoma (GBM) is the most frequent and severe glioma subtype, accounting for approximately 50% of diffuse gliomas. The aim of the present study was to evaluate morphological MRI characteristics in histologically-proven PCNSL and GBM at the time of their initial presentation. METHODS: We retrospectively evaluated standard diagnostic MRI examinations in 54 immunocompetent patients (26 female, 28 male; age 62.6 ± 11.5 years) with histologically-proven PCNSL and 54 GBM subjects (21 female, 33 male; age 59 ± 14 years). RESULTS: Several significant differences between both infiltrative brain tumors were found. PCNSL lesions enhanced homogenously in 64.8% of cases, while nonhomogeneous enhancement was observed in 98.1% of GBM cases. Necrosis was present in 88.9% of GBM lesions and only 5.6% of PCNSL lesions. PCNSL presented as multiple lesions in 51.9% cases and in 35.2% of GBM cases; however, diffuse infiltrative type of brain involvement was observed only in PCNSL (24.1%). Optic pathways were infiltrated more commonly in PCNSL than in GBM (42.6% vs. 5.6%, respectively, p <0.001). Other cranial nerves were affected in 5.6% of PCNSL, and in none of GBM. Signs of bleeding were rare in PCNSL (5.6%) and common in GBM (44.4%); p < 0.001. Both supratentorial and infratentorial localization was present only in PCNSL (27.7%). Involvement of the basal ganglia was more common in PCNSL (55.6%) than in GBM (18.5%); (p < 0.001). Cerebral cortex was affected significantly more often in GBM (83.3%) than in PCNSL (51.9%); mostly by both enhancing and non-enhancing infiltration. CONCLUSION: Routine morphological MRI is capable of differentiating between GBM and PCNSL lesions in many cases at time of initial presentation. A solitary infiltrative supratentorial lesion with nonhomogeneous enhancement and necrosis was typical for GBM. PCNSL presented with multiple lesions that enhanced homogenously or as diffuse infiltrative type of brain involvement, often with basal ganglia and optic pathways affection.
650    _2
$a senioři $7 D000368
650    _2
$a nádory centrálního nervového systému $x diagnostické zobrazování $7 D016543
650    _2
$a diferenciální diagnóza $7 D003937
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a glioblastom $x diagnostické zobrazování $7 D005909
650    _2
$a lidé $7 D006801
650    _2
$a lymfom $x diagnostické zobrazování $7 D008223
650    12
$a magnetická rezonanční tomografie $7 D008279
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
655    _2
$a hodnotící studie $7 D023362
655    _2
$a časopisecké články $7 D016428
700    1_
$a Koubska, E $u Department of Radiology, Na Homolce Hospital, Roentgenova 2, Prague, 15000, Czech Republic.
700    1_
$a Weichet, J $u Department of Radiology, Na Homolce Hospital, Roentgenova 2, Prague, 15000, Czech Republic. Department of Radiology, Third Faculty of Medicine, Charles University in Prague and Faculty Hospital Kralovske Vinohrady, Ruska 87, Prague, 10000, Czech Republic.
700    1_
$a Klener, J $u Department of Neurosurgery, Na Homolce Hospital, Roentgenova 2, Prague, 15000, Czech Republic.
700    1_
$a Rulseh, Aaron Michael $7 xx0243723 $u Department of Radiology, Na Homolce Hospital, Roentgenova 2, Prague, 15000, Czech Republic. Department of Radiology, 1st Faculty of Medicine and General University Hospital, Charles University, Prague, Czech Republic
700    1_
$a Liscak, R $u Department of Stereotactic and Radiation Neurosurgery, Na Homolce Hospital, Roentgenova 2, Prague, 15000, Czech Republic.
700    1_
$a Vojtech, Z $u Department of Neurology, Na Homolce Hospital, Roentgenova 2, Prague, 15000, Czech Republic. Department of Neurology, Third Faculty of Medicine, Charles University in Prague, Ruska 87, Prague, 10000, Czech Republic.
773    0_
$w MED00173162 $t Cancer imaging the official publication of the International Cancer Imaging Society $x 1470-7330 $g Roč. 16, č. 1 (2016), s. 40
856    41
$u https://pubmed.ncbi.nlm.nih.gov/27894359 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20170413 $b ABA008
991    __
$a 20200131105731 $b ABA008
999    __
$a ok $b bmc $g 1199836 $s 974149
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2016 $b 16 $c 1 $d 40 $e 20161129 $i 1470-7330 $m Cancer imaging $n Cancer Imaging $x MED00173162
LZP    __
$a Pubmed-20170413

Find record

Citation metrics

Archiving options