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Using ferromagnetic nanoparticles with low Curie temperature for magnetic resonance imaging-guided thermoablation
V. Herynek, K. Turnovcová, P. Veverka, T. Dědourková, P. Žvátora, P. Jendelová, A. Gálisová, L. Kosinová, K. Jiráková, E. Syková,
Jazyk angličtina Země Nový Zéland
Typ dokumentu časopisecké články
NLK
Directory of Open Access Journals
od 2006
Free Medical Journals
od 2006
PubMed Central
od 2006
Europe PubMed Central
od 2006
ProQuest Central
od 2012-01-01
Open Access Digital Library
od 2006-01-01
Open Access Digital Library
od 2009-01-01
Taylor & Francis Open Access
od 2006-09-01
Medline Complete (EBSCOhost)
od 2012-01-01
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od 2012-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2006
PubMed
27540292
DOI
10.2147/ijn.s109582
Knihovny.cz E-zdroje
- MeSH
- ablace přístrojové vybavení metody MeSH
- indukovaná hypertermie metody MeSH
- kontrastní látky * chemie farmakokinetika MeSH
- magnetická rezonanční tomografie přístrojové vybavení metody MeSH
- magnety MeSH
- nádorové buněčné linie MeSH
- nanočástice * chemie MeSH
- oxid křemičitý chemie MeSH
- oxidy chemie MeSH
- potkani Wistar MeSH
- sloučeniny vápníku chemie MeSH
- suspenze MeSH
- teplota MeSH
- titan chemie MeSH
- xenogenní modely - testy antitumorózní aktivity MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
INTRODUCTION: Magnetic nanoparticles (NPs) represent a tool for use in magnetic resonance imaging (MRI)-guided thermoablation of tumors using an external high-frequency (HF) magnetic field. To avoid local overheating, perovskite NPs with a lower Curie temperature (T c) were proposed for use in thermotherapy. However, deposited power decreases when approaching the Curie temperature and consequently may not be sufficient for effective ablation. The goal of the study was to test this hypothesis. METHODS: Perovskite NPs (T c =66°C-74°C) were characterized and tested both in vitro and in vivo. In vitro, the cells suspended with NPs were exposed to a HF magnetic field together with control samples. In vivo, a NP suspension was injected into a induced tumor in rats. Distribution was checked by MRI and the rats were exposed to a HF field together with control animals. Apoptosis in the tissue was evaluated. RESULTS AND DISCUSSION: In vitro, the high concentration of suspended NPs caused an increase of the temperature in the cell sample, leading to cell death. In vivo, MRI confirmed distribution of the NPs in the tumor. The temperature in the tumor with injected NPs did not increase substantially in comparison with animals without particles during HF exposure. We proved that the deposited power from the NPs is too small and that thermoregulation of the animal is sufficient to conduct the heat away. Histology did not detect substantially higher apoptosis in NP-treated animals after ablation. CONCLUSION: Magnetic particles with low T c can be tracked in vivo by MRI and heated by a HF field. The particles are capable of inducing cell apoptosis in suspensions in vitro at high concentrations only. However, their effect in the case of extracellular deposition in vivo is questionable due to low deposited power and active thermoregulation of the tissue.
Department of Analytical Chemistry Institute of Chemical Technology
Department of Inorganic Technology Faculty of Chemical Technology University of Pardubice
Department of Magnetics and Superconductors Institute of Physics Czech Academy of Sciences Prague
Department of Neuroscience Institute of Experimental Medicine
Diabetes Center Institute for Clinical and Experimental Medicine Prague Czech Republic
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- $a INTRODUCTION: Magnetic nanoparticles (NPs) represent a tool for use in magnetic resonance imaging (MRI)-guided thermoablation of tumors using an external high-frequency (HF) magnetic field. To avoid local overheating, perovskite NPs with a lower Curie temperature (T c) were proposed for use in thermotherapy. However, deposited power decreases when approaching the Curie temperature and consequently may not be sufficient for effective ablation. The goal of the study was to test this hypothesis. METHODS: Perovskite NPs (T c =66°C-74°C) were characterized and tested both in vitro and in vivo. In vitro, the cells suspended with NPs were exposed to a HF magnetic field together with control samples. In vivo, a NP suspension was injected into a induced tumor in rats. Distribution was checked by MRI and the rats were exposed to a HF field together with control animals. Apoptosis in the tissue was evaluated. RESULTS AND DISCUSSION: In vitro, the high concentration of suspended NPs caused an increase of the temperature in the cell sample, leading to cell death. In vivo, MRI confirmed distribution of the NPs in the tumor. The temperature in the tumor with injected NPs did not increase substantially in comparison with animals without particles during HF exposure. We proved that the deposited power from the NPs is too small and that thermoregulation of the animal is sufficient to conduct the heat away. Histology did not detect substantially higher apoptosis in NP-treated animals after ablation. CONCLUSION: Magnetic particles with low T c can be tracked in vivo by MRI and heated by a HF field. The particles are capable of inducing cell apoptosis in suspensions in vitro at high concentrations only. However, their effect in the case of extracellular deposition in vivo is questionable due to low deposited power and active thermoregulation of the tissue.
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