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Toward high-resolution population genomics using archaeological samples
I. Morozova, P. Flegontov, AS. Mikheyev, S. Bruskin, H. Asgharian, P. Ponomarenko, V. Klyuchnikov, G. ArunKumar, E. Prokhortchouk, Y. Gankin, E. Rogaev, Y. Nikolsky, A. Baranova, E. Elhaik, TV. Tatarinova,
Language English Country England, Great Britain
Document type Journal Article, Review
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PubMed
27436340
DOI
10.1093/dnares/dsw029
Knihovny.cz E-resources
- MeSH
- Genome, Human * MeSH
- Genomics methods MeSH
- Humans MeSH
- Evolution, Molecular * MeSH
- Genetics, Population methods MeSH
- Sequence Analysis, DNA methods MeSH
- DNA, Ancient * MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
The term 'ancient DNA' (aDNA) is coming of age, with over 1,200 hits in the PubMed database, beginning in the early 1980s with the studies of 'molecular paleontology'. Rooted in cloning and limited sequencing of DNA from ancient remains during the pre-PCR era, the field has made incredible progress since the introduction of PCR and next-generation sequencing. Over the last decade, aDNA analysis ushered in a new era in genomics and became the method of choice for reconstructing the history of organisms, their biogeography, and migration routes, with applications in evolutionary biology, population genetics, archaeogenetics, paleo-epidemiology, and many other areas. This change was brought by development of new strategies for coping with the challenges in studying aDNA due to damage and fragmentation, scarce samples, significant historical gaps, and limited applicability of population genetics methods. In this review, we describe the state-of-the-art achievements in aDNA studies, with particular focus on human evolution and demographic history. We present the current experimental and theoretical procedures for handling and analysing highly degraded aDNA. We also review the challenges in the rapidly growing field of ancient epigenomics. Advancement of aDNA tools and methods signifies a new era in population genetics and evolutionary medicine research.
Department of Animal and Plant Sciences University of Sheffield Sheffield South Yorkshire UK
Donskaya Archeologia Rostov Russia
Institute of Evolutionary Medicine University of Zurich Zurich Switzerland
School of Chemical and Biotechnology SASTRA University Tanjore India
References provided by Crossref.org
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