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A novel HLA-B allele, HLA-B*35:279, identified by sequencing-based typing in a Czech patient

F. Mrazek, J. Onderkova, N. Königova, V. Siffnerova, M. Vrana, Z. Ambruzova, I. Skoumalova, M. Petrek, L. Raida,

. 2016 ; 43 (4) : 246-248. [pub] 20160608

Language English Country England, Great Britain

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc17013791

Grant support
NT12454 MZ0 CEP Register

The identification of a novel HLA-B*35:279 allele in a Czech patient is described. This allele is identical to the B*35:03:01 variant except the G/A nucleotide exchange at position 652 of the HLA-B gene that corresponds to the amino acid substitution from valine to isoleucine in alpha 3 domain of the HLA-B antigen.

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$a The identification of a novel HLA-B*35:279 allele in a Czech patient is described. This allele is identical to the B*35:03:01 variant except the G/A nucleotide exchange at position 652 of the HLA-B gene that corresponds to the amino acid substitution from valine to isoleucine in alpha 3 domain of the HLA-B antigen.
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$a Šiffnerová, Věra $u Department of HLA, Institute of Hematology and Blood Transfusion, Prague, Czech Republic. $7 xx0217369
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$a Skoumalova, I $u Department of Hemato-Oncology, University Hospital and Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.
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