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Penile Analogue of Stratified Mucin-Producing Intraepithelial Lesion of the Cervix: The First Described Case. A Diagnostic Pitfall
M. Michal, M. Michal, M. Miesbauerova, J. Hercogova, B. Skopalikova, DV. Kazakov,
Language English Country United States
Document type Case Reports, Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Biopsy MeSH
- Diagnostic Errors MeSH
- Uterine Cervical Dysplasia chemistry pathology MeSH
- Paget Disease, Extramammary pathology MeSH
- Immunohistochemistry MeSH
- Cyclin-Dependent Kinase Inhibitor p16 analysis MeSH
- Neoplasm Invasiveness MeSH
- Carcinoma in Situ chemistry pathology virology MeSH
- Carcinoma chemistry pathology virology MeSH
- Middle Aged MeSH
- Humans MeSH
- Human papillomavirus 16 isolation & purification MeSH
- Metaplasia MeSH
- Biomarkers, Tumor analysis MeSH
- Neoplasms, Cystic, Mucinous, and Serous chemistry pathology virology MeSH
- Uterine Cervical Neoplasms chemistry pathology MeSH
- Penile Neoplasms chemistry pathology virology MeSH
- Goblet Cells chemistry pathology virology MeSH
- Predictive Value of Tests MeSH
- Disease Progression MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Research Support, Non-U.S. Gov't MeSH
The authors report a case where undifferentiated (classic) penile intraepithelial neoplasia was associated with the presence of goblet cells throughout the full epithelial thickness and which later progressed into an invasive carcinoma. The lesion evolved in three consecutive biopsies from only surface epithelium occupying numerous goblet cells in the first to variably sized solid nodules in the dermis composed of atypical squamous and/or basaloid cells intermixed with numerous goblet cells in the third biopsy. Both cellular components expressed CK7 and p16 protein. Human Papillomavirus (HPV) genotyping revealed high risk HPV type 16. To the best of our knowledge, this is the first description of such a lesion occurring on the penis, which can be considered the penile analogue of cervical stratified mucin-producing intraepithelial lesion (SMILE). The correct diagnosis was rendered retrospectively, after recognition of the existence of a vulvar lesion resembling cervical SMILE. The initial biopsy was misinterpreted as extramammary Paget disease, which also constitutes the main pitfall in the differential diagnosis. Another important differential diagnosis is penile/vulvar mucinous metaplasia. The finding of atypical squamous epithelial cells positive for p16 associated with mucinous cells present throughout the full epithelial thickness is a clue to the diagnosis of penile SMILE.
References provided by Crossref.org
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- $a Michal, Michael $u *Department of Pathology, Charles University, Biomedical Center, Faculty of Medicine in Plzen and Charles University Hospital Plzen, Pilsen, Czech Republic; †Department of Pathology, Charles University, Medical Faculty and Charles University Hospital Plzen, Pilsen, Czech Republic; ‡Department of Dermatovenereology, Charles University, 2nd Faculty of Medicine and Bulovka Hospital, Prague, Czech Republic; and §Department of Pathology, Charles University, 2nd Faculty of Medicine, Prague, Czech Republic.
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- $a The authors report a case where undifferentiated (classic) penile intraepithelial neoplasia was associated with the presence of goblet cells throughout the full epithelial thickness and which later progressed into an invasive carcinoma. The lesion evolved in three consecutive biopsies from only surface epithelium occupying numerous goblet cells in the first to variably sized solid nodules in the dermis composed of atypical squamous and/or basaloid cells intermixed with numerous goblet cells in the third biopsy. Both cellular components expressed CK7 and p16 protein. Human Papillomavirus (HPV) genotyping revealed high risk HPV type 16. To the best of our knowledge, this is the first description of such a lesion occurring on the penis, which can be considered the penile analogue of cervical stratified mucin-producing intraepithelial lesion (SMILE). The correct diagnosis was rendered retrospectively, after recognition of the existence of a vulvar lesion resembling cervical SMILE. The initial biopsy was misinterpreted as extramammary Paget disease, which also constitutes the main pitfall in the differential diagnosis. Another important differential diagnosis is penile/vulvar mucinous metaplasia. The finding of atypical squamous epithelial cells positive for p16 associated with mucinous cells present throughout the full epithelial thickness is a clue to the diagnosis of penile SMILE.
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