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Genome of Leptomonas pyrrhocoris: a high-quality reference for monoxenous trypanosomatids and new insights into evolution of Leishmania
P. Flegontov, A. Butenko, S. Firsov, N. Kraeva, M. Eliáš, MC. Field, D. Filatov, O. Flegontova, ES. Gerasimov, J. Hlaváčová, A. Ishemgulova, AP. Jackson, S. Kelly, AY. Kostygov, MD. Logacheva, DA. Maslov, FR. Opperdoes, A. O'Reilly, J. Sádlová,...
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
NLK
Directory of Open Access Journals
od 2011
Free Medical Journals
od 2011
Nature Open Access
od 2011-12-01
PubMed Central
od 2011
Europe PubMed Central
od 2011
ProQuest Central
od 2011-01-01
Open Access Digital Library
od 2011-01-01
Open Access Digital Library
od 2011-01-01
Health & Medicine (ProQuest)
od 2011-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2011
PubMed
27021793
DOI
10.1038/srep23704
Knihovny.cz E-zdroje
- MeSH
- druhová specificita MeSH
- energetický metabolismus genetika MeSH
- fylogeneze MeSH
- genom protozoální genetika MeSH
- genová ontologie MeSH
- Leishmania klasifikace genetika patogenita MeSH
- molekulární evoluce * MeSH
- protozoální geny genetika MeSH
- stanovení celkové genové exprese metody MeSH
- Trypanosomatina klasifikace genetika patogenita MeSH
- virulence genetika MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Many high-quality genomes are available for dixenous (two hosts) trypanosomatid species of the genera Trypanosoma, Leishmania, and Phytomonas, but only fragmentary information is available for monoxenous (single-host) trypanosomatids. In trypanosomatids, monoxeny is ancestral to dixeny, thus it is anticipated that the genome sequences of the key monoxenous parasites will be instrumental for both understanding the origin of parasitism and the evolution of dixeny. Here, we present a high-quality genome for Leptomonas pyrrhocoris, which is closely related to the dixenous genus Leishmania. The L. pyrrhocoris genome (30.4 Mbp in 60 scaffolds) encodes 10,148 genes. Using the L. pyrrhocoris genome, we pinpointed genes gained in Leishmania. Among those genes, 20 genes with unknown function had expression patterns in the Leishmania mexicana life cycle suggesting their involvement in virulence. By combining differential expression data for L. mexicana, L. major and Leptomonas seymouri, we have identified several additional proteins potentially involved in virulence, including SpoU methylase and U3 small nucleolar ribonucleoprotein IMP3. The population genetics of L. pyrrhocoris was also addressed by sequencing thirteen strains of different geographic origin, allowing the identification of 1,318 genes under positive selection. This set of genes was significantly enriched in components of the cytoskeleton and the flagellum.
Department of Parasitology Faculty of Science Charles University 128 44 Prague Czech Republic
Department of Plant Sciences University of Oxford Oxford OX1 3RB UK
e Duve Institute Université Catholique de Louvain 1200 Brussels Belgium
Institute of Molecular Genetics Czech Academy of Sciences 142 20 Prague Czech Republic
Life Science Research Centre Faculty of Science University of Ostrava 710 00 Ostrava Czech Republic
School of Life Sciences University of Dundee Dundee DD1 5EH UK
University of California at Riverside Riverside 92521 CA USA
Citace poskytuje Crossref.org
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