Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Febrile urinary tract infection after pediatric kidney transplantation: a multicenter, prospective observational study

F. Weigel, A. Lemke, B. Tönshoff, L. Pape, H. Fehrenbach, M. Henn, B. Hoppe, T. Jungraithmayr, M. Konrad, G. Laube, M. Pohl, T. Seeman, H. Staude, MJ. Kemper, U. John,

. 2016 ; 31 (6) : 1021-8. [pub] 20160111

Language English Country Germany

Document type Journal Article, Multicenter Study, Observational Study, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc17014167
E-resources Online Full text

NLK ProQuest Central from 1996-08-01 to 1 year ago
Medline Complete (EBSCOhost) from 1996-08-01 to 1 year ago
Nursing & Allied Health Database (ProQuest) from 1996-08-01 to 1 year ago
Health & Medicine (ProQuest) from 1996-08-01 to 1 year ago
Family Health Database (ProQuest) from 1996-08-01 to 1 year ago

Links

PubMed 26754038
DOI 10.1007/s00467-015-3292-2
Knihovny.cz E-resources

BACKGROUND: Febrile urinary tract infections (fUTIs) are common after kidney transplantation (KTx); however, prospective data in a multicenter pediatric cohort are lacking. We designed a prospective registry to record data on fUTI before and after pediatric KTx. METHODS: Ninety-eight children (58 boys and 40 girls) ≤ 18 years from 14 mid-European centers received a kidney transplant and completed a 2-year follow-up. RESULTS: Posttransplant, 38.7% of patients had at least one fUTI compared with 21.4% before KTx (p = 0.002). Before KTx, fUTI was more frequent in patients with congenital anomalies of kidneys and urinary tract (CAKUT) vs. patients without (38% vs. 12%; p = 0.005). After KTx, fUTI were equally frequent in both groups (48.7% vs. 32.2%; p = 0.14). First fUTI posttransplant occurred earlier in boys compared with girls: median range 4 vs. 13.5 years (p = 0.002). Graft function worsened (p < 0.001) during fUTI, but no difference was recorded after 2 years. At least one recurrence of fUTI was encountered in 58%. CONCLUSION: This prospective study confirms a high incidence of fUTI after pediatric KTx, which is not restricted to patients with CAKUT; fUTIs have a negative impact on graft function during the infectious episode but not on 2-year graft outcome.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc17014167
003      
CZ-PrNML
005      
20170427101523.0
007      
ta
008      
170413s2016 gw f 000 0|eng||
009      
AR
024    7_
$a 10.1007/s00467-015-3292-2 $2 doi
035    __
$a (PubMed)26754038
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a gw
100    1_
$a Weigel, Friederike $u Pediatric Nephrology, University Medical Center Jena, Kochstrasse 2, 07743, Jena, Germany. Friederike.Weigel@med.uni-jena.de.
245    10
$a Febrile urinary tract infection after pediatric kidney transplantation: a multicenter, prospective observational study / $c F. Weigel, A. Lemke, B. Tönshoff, L. Pape, H. Fehrenbach, M. Henn, B. Hoppe, T. Jungraithmayr, M. Konrad, G. Laube, M. Pohl, T. Seeman, H. Staude, MJ. Kemper, U. John,
520    9_
$a BACKGROUND: Febrile urinary tract infections (fUTIs) are common after kidney transplantation (KTx); however, prospective data in a multicenter pediatric cohort are lacking. We designed a prospective registry to record data on fUTI before and after pediatric KTx. METHODS: Ninety-eight children (58 boys and 40 girls) ≤ 18 years from 14 mid-European centers received a kidney transplant and completed a 2-year follow-up. RESULTS: Posttransplant, 38.7% of patients had at least one fUTI compared with 21.4% before KTx (p = 0.002). Before KTx, fUTI was more frequent in patients with congenital anomalies of kidneys and urinary tract (CAKUT) vs. patients without (38% vs. 12%; p = 0.005). After KTx, fUTI were equally frequent in both groups (48.7% vs. 32.2%; p = 0.14). First fUTI posttransplant occurred earlier in boys compared with girls: median range 4 vs. 13.5 years (p = 0.002). Graft function worsened (p < 0.001) during fUTI, but no difference was recorded after 2 years. At least one recurrence of fUTI was encountered in 58%. CONCLUSION: This prospective study confirms a high incidence of fUTI after pediatric KTx, which is not restricted to patients with CAKUT; fUTIs have a negative impact on graft function during the infectious episode but not on 2-year graft outcome.
650    _2
$a mladiství $7 D000293
650    _2
$a dítě $7 D002648
650    _2
$a předškolní dítě $7 D002675
650    _2
$a opožděný nástup funkce štěpu $x epidemiologie $x etiologie $7 D051799
650    _2
$a Evropa $x epidemiologie $7 D005060
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a horečka $x epidemiologie $x etiologie $7 D005334
650    _2
$a rejekce štěpu $x epidemiologie $x etiologie $7 D006084
650    _2
$a lidé $7 D006801
650    _2
$a incidence $7 D015994
650    _2
$a nemoci ledvin $x chirurgie $7 D007674
650    _2
$a transplantace ledvin $x škodlivé účinky $7 D016030
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a prospektivní studie $7 D011446
650    _2
$a rizikové faktory $7 D012307
650    _2
$a sexuální faktory $7 D012737
650    _2
$a výsledek terapie $7 D016896
650    _2
$a infekce močového ústrojí $x komplikace $x epidemiologie $x etiologie $7 D014552
655    _2
$a časopisecké články $7 D016428
655    _2
$a multicentrická studie $7 D016448
655    _2
$a pozorovací studie $7 D064888
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Lemke, Anja $u Pediatric Nephrology, University Childrens Hospital, University Medical Center Hamburg Eppendorf, Hamburg, Germany.
700    1_
$a Tönshoff, Burkhard $u Department of Pediatrics I, University Children's Hospital, Heidelberg, Germany.
700    1_
$a Pape, Lars $u Pediatric Nephrology, Hannover Medical School, Hannover, Germany.
700    1_
$a Fehrenbach, Henry $u Children's Hospital Memmingen, Memmingen, Germany.
700    1_
$a Henn, Michael $u Pediatric Nephrology, Children's Hospital St. Georg, Leipzig, Germany.
700    1_
$a Hoppe, Bernd $u Pediatric Nephrology, University Medical Center Bonn, Bonn, Germany.
700    1_
$a Jungraithmayr, Therese $u Department of Pediatrics I, University Medical Center Innsbruck, Innsbruck, Austria.
700    1_
$a Konrad, Martin $u Pediatric Nephrology, University Medical Center Münster, Münster, Germany.
700    1_
$a Laube, Guido $u Department of Nephrology, University Children's Hospital, Zurich, Switzerland.
700    1_
$a Pohl, Martin $u Pediatric Nephrology, University Children's Hospital, Freiburg, Germany.
700    1_
$a Seeman, Tomáš $u 2nd School of Medicine, University Hospital Motol, Charles University Prague, Prague, Czech Republic.
700    1_
$a Staude, Hagen $u Pediatric Nephrology, University Children's Hospital, Rostock, Germany.
700    1_
$a Kemper, Markus J $u Pediatric Nephrology, University Childrens Hospital, University Medical Center Hamburg Eppendorf, Hamburg, Germany.
700    1_
$a John, Ulrike $u Pediatric Nephrology, University Medical Center Jena, Kochstrasse 2, 07743, Jena, Germany.
773    0_
$w MED00003733 $t Pediatric nephrology (Berlin, Germany) $x 1432-198X $g Roč. 31, č. 6 (2016), s. 1021-8
856    41
$u https://pubmed.ncbi.nlm.nih.gov/26754038 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20170413 $b ABA008
991    __
$a 20170427101843 $b ABA008
999    __
$a ok $b bmc $g 1200632 $s 974945
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2016 $b 31 $c 6 $d 1021-8 $e 20160111 $i 1432-198X $m Pediatric nephrology $n Pediatr Nephrol $x MED00003733
LZP    __
$a Pubmed-20170413

Find record

Citation metrics

Archiving options