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PubMed

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Febrile urinary tract infection after pediatric kidney transplantation: a multicenter, prospective observational study

Weigel, Friederike
Author Weigel, Friederike Pediatric Nephrology, University Medical Center Jena, Kochstrasse 2, 07743, Jena, Germany. Friederike.Weigel@med.uni-jena.de
Lemke, Anja
Author Lemke, Anja Pediatric Nephrology, University Childrens Hospital, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Tönshoff, Burkhard
Author Tönshoff, Burkhard Department of Pediatrics I, University Children's Hospital, Heidelberg, Germany
Pape, Lars
Author Pape, Lars Pediatric Nephrology, Hannover Medical School, Hannover, Germany
Fehrenbach, Henry
Author Fehrenbach, Henry Children's Hospital Memmingen, Memmingen, Germany
Henn, Michael
Author Henn, Michael Pediatric Nephrology, Children's Hospital St. Georg, Leipzig, Germany
Hoppe, Bernd
Author Hoppe, Bernd Pediatric Nephrology, University Medical Center Bonn, Bonn, Germany
Jungraithmayr, Therese
Author Jungraithmayr, Therese Department of Pediatrics I, University Medical Center Innsbruck, Innsbruck, Austria
Konrad, Martin
Author Konrad, Martin Pediatric Nephrology, University Medical Center Münster, Münster, Germany
Laube, Guido
Author Laube, Guido Department of Nephrology, University Children's Hospital, Zurich, Switzerland
Pohl, Martin
Author Pohl, Martin Pediatric Nephrology, University Children's Hospital, Freiburg, Germany
Seeman, Tomáš
Author Seeman, Tomáš 2nd School of Medicine, University Hospital Motol, Charles University Prague, Prague, Czech Republic
Staude, Hagen
Author Staude, Hagen Pediatric Nephrology, University Children's Hospital, Rostock, Germany
Kemper, Markus J
Author Kemper, Markus J Pediatric Nephrology, University Childrens Hospital, University Medical Center Hamburg Eppendorf, Hamburg, Germany
John, Ulrike
Author John, Ulrike Pediatric Nephrology, University Medical Center Jena, Kochstrasse 2, 07743, Jena, Germany

Pediatric nephrology (Berlin, Germany). 2016 Jun ; 31 (6) : 1021-8. [epub] 20160111

Pediatr Nephrol
ISSN 1432-198X | 0931-041X
Source

Language English Country Germany Media print-electronic

Document type Journal Article, Multicenter Study, Observational Study, Research Support, Non-U.S. Gov't

Persistent link https://www.medvik.cz/link/pmid26754038

PubMed 26754038
DOI 10.1007/s00467-015-3292-2
PII: 10.1007/s00467-015-3292-2
Knihovny.cz E-resources

Keywords
CAKUT, Children, Kidney transplantation, Outcome, Urinary tract infection,
MeSH
Child MeSH
Fever epidemiology etiology MeSH
Incidence MeSH
Urinary Tract Infections complications epidemiology etiology MeSH
Humans MeSH
Adolescent MeSH
Kidney Diseases surgery MeSH
Delayed Graft Function epidemiology etiology MeSH
Child, Preschool MeSH
Prospective Studies MeSH
Graft Rejection epidemiology etiology MeSH
Risk Factors MeSH
Sex Factors MeSH
Kidney Transplantation adverse effects MeSH
Treatment Outcome MeSH
Check Tag
Child MeSH
Humans MeSH
Adolescent MeSH
Male MeSH
Child, Preschool MeSH
Female MeSH
Publication type
Journal Article MeSH
Multicenter Study MeSH
Observational Study MeSH
Research Support, Non-U.S. Gov't MeSH
Geographicals
Europe epidemiology MeSH

BACKGROUND: Febrile urinary tract infections (fUTIs) are common after kidney transplantation (KTx); however, prospective data in a multicenter pediatric cohort are lacking. We designed a prospective registry to record data on fUTI before and after pediatric KTx. METHODS: Ninety-eight children (58 boys and 40 girls) ≤ 18 years from 14 mid-European centers received a kidney transplant and completed a 2-year follow-up. RESULTS: Posttransplant, 38.7% of patients had at least one fUTI compared with 21.4% before KTx (p = 0.002). Before KTx, fUTI was more frequent in patients with congenital anomalies of kidneys and urinary tract (CAKUT) vs. patients without (38% vs. 12%; p = 0.005). After KTx, fUTI were equally frequent in both groups (48.7% vs. 32.2%; p = 0.14). First fUTI posttransplant occurred earlier in boys compared with girls: median range 4 vs. 13.5 years (p = 0.002). Graft function worsened (p < 0.001) during fUTI, but no difference was recorded after 2 years. At least one recurrence of fUTI was encountered in 58%. CONCLUSION: This prospective study confirms a high incidence of fUTI after pediatric KTx, which is not restricted to patients with CAKUT; fUTIs have a negative impact on graft function during the infectious episode but not on 2-year graft outcome.

2nd School of Medicine University Hospital Motol Charles University Prague Prague Czech Republic

Children's Hospital Memmingen Memmingen Germany

Department of Nephrology University Children's Hospital Zurich Switzerland

Department of Pediatrics 1 University Children's Hospital Heidelberg Germany

Department of Pediatrics 1 University Medical Center Innsbruck Innsbruck Austria

Pediatric Nephrology Children's Hospital St Georg Leipzig Germany

Pediatric Nephrology Hannover Medical School Hannover Germany

Pediatric Nephrology University Children's Hospital Freiburg Germany

Pediatric Nephrology University Children's Hospital Rostock Germany

Pediatric Nephrology University Childrens Hospital University Medical Center Hamburg Eppendorf Hamburg Germany

Pediatric Nephrology University Medical Center Bonn Bonn Germany

Pediatric Nephrology University Medical Center Jena Kochstrasse 2 07743 Jena Germany