Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Renin-angiotensin system blockade alone or combined with ETA receptor blockade: effects on the course of chronic kidney disease in 5/6 nephrectomized Ren-2 transgenic hypertensive rats

L. Sedláková, V. Čertíková Chábová, Š. Doleželová, P. Škaroupková, L. Kopkan, Z. Husková, L. Červenková, S. Kikerlová, I. Vaněčková, J. Sadowski, E. Kompanowska-Jezierska, P. Kujal, HJ. Kramer, L. Červenka,

. 2017 ; 39 (2) : 183-195. [pub] 20170301

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc17023214

Grantová podpora
NV15-28671A MZ0 CEP - Centrální evidence projektů

BACKGROUND: Early addition of endothelin (ET) type A (ETA) receptor blockade to complex renin-angiotensin system (RAS) blockade has previously been shown to provide better renoprotection against progression of chronic kidney disease (CKD) in Ren-2 transgenic hypertensive rats (TGR) after 5/6 renal ablation (5/6 NX). In this study, we examined if additional protection is provided when ETA blockade is applied in rats with already developed CKD. METHODS: For complex RAS inhibition, an angiotensin-converting enzyme inhibitor along with angiotensin II type 1 receptor blocker was used. Alternatively, ETA receptor blocker was added to the RAS blockade. The treatments were initiated 6 weeks after 5/6 NX and the follow-up period was 50 weeks. RESULTS: When applied in established CKD, addition of ETA receptor blockade to the complex RAS blockade brought no further improvement of the survival rate (30% in both groups); surprisingly, aggravated albuminuria (588 ± 47 vs. 245 ± 38 mg/24 h, p < 0.05) did not reduce renal glomerular injury index (1.25 ± 0.29 vs. 1.44 ± 0.26), did not prevent the decrease in creatinine clearance (203 ± 21 vs. 253 ± 17 μl/min/100 g body weight), and did not attenuate cardiac hypertrophy to a greater extent than observed in 5/6 NX TGR treated with complex RAS blockade alone. CONCLUSIONS: When applied in the advanced phase of CKD, addition of ETA receptor blockade to the complex RAS blockade brings no further beneficial renoprotective effects on the CKD progression in 5/6 NX TGR, in addition to those seen with RAS blockade alone.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc17023214
003      
CZ-PrNML
005      
20220531083156.0
007      
ta
008      
170720s2017 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1080/10641963.2016.1235184 $2 doi
035    __
$a (PubMed)28287881
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Sedláková, Lenka, $u a Center for Experimental Medicine, Institute for Clinical and Experimental Medicine , Prague , Czech Republic. b Department of Physiology, Faculty of Science , Charles University , Prague , Czech Republic. $d 1992- $7 xx0273377
245    10
$a Renin-angiotensin system blockade alone or combined with ETA receptor blockade: effects on the course of chronic kidney disease in 5/6 nephrectomized Ren-2 transgenic hypertensive rats / $c L. Sedláková, V. Čertíková Chábová, Š. Doleželová, P. Škaroupková, L. Kopkan, Z. Husková, L. Červenková, S. Kikerlová, I. Vaněčková, J. Sadowski, E. Kompanowska-Jezierska, P. Kujal, HJ. Kramer, L. Červenka,
520    9_
$a BACKGROUND: Early addition of endothelin (ET) type A (ETA) receptor blockade to complex renin-angiotensin system (RAS) blockade has previously been shown to provide better renoprotection against progression of chronic kidney disease (CKD) in Ren-2 transgenic hypertensive rats (TGR) after 5/6 renal ablation (5/6 NX). In this study, we examined if additional protection is provided when ETA blockade is applied in rats with already developed CKD. METHODS: For complex RAS inhibition, an angiotensin-converting enzyme inhibitor along with angiotensin II type 1 receptor blocker was used. Alternatively, ETA receptor blocker was added to the RAS blockade. The treatments were initiated 6 weeks after 5/6 NX and the follow-up period was 50 weeks. RESULTS: When applied in established CKD, addition of ETA receptor blockade to the complex RAS blockade brought no further improvement of the survival rate (30% in both groups); surprisingly, aggravated albuminuria (588 ± 47 vs. 245 ± 38 mg/24 h, p < 0.05) did not reduce renal glomerular injury index (1.25 ± 0.29 vs. 1.44 ± 0.26), did not prevent the decrease in creatinine clearance (203 ± 21 vs. 253 ± 17 μl/min/100 g body weight), and did not attenuate cardiac hypertrophy to a greater extent than observed in 5/6 NX TGR treated with complex RAS blockade alone. CONCLUSIONS: When applied in the advanced phase of CKD, addition of ETA receptor blockade to the complex RAS blockade brings no further beneficial renoprotective effects on the CKD progression in 5/6 NX TGR, in addition to those seen with RAS blockade alone.
650    _2
$a albuminurie $7 D000419
650    _2
$a blokátory receptorů AT1 pro angiotensin II $x farmakologie $7 D047228
650    _2
$a inhibitory ACE $x farmakologie $7 D000806
650    _2
$a angiotensiny $x účinky léků $x metabolismus $7 D000809
650    _2
$a zvířata $7 D000818
650    _2
$a krevní tlak $x účinky léků $7 D001794
650    _2
$a kardiomegalie $7 D006332
650    _2
$a kreatinin $x metabolismus $7 D003404
650    _2
$a progrese nemoci $7 D018450
650    _2
$a kombinovaná farmakoterapie $7 D004359
650    _2
$a antagonisté endotelinového receptoru A $x farmakologie $7 D065130
650    _2
$a hodnoty glomerulární filtrace $x účinky léků $7 D005919
650    _2
$a hypertenze $7 D006973
650    _2
$a indoly $x farmakologie $7 D007211
650    _2
$a ledviny $x účinky léků $x metabolismus $7 D007668
650    _2
$a losartan $x farmakologie $7 D019808
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a nefrektomie $7 D009392
650    _2
$a pyrrolidiny $x farmakologie $7 D011759
650    _2
$a krysa rodu Rattus $7 D051381
650    _2
$a potkani Sprague-Dawley $7 D017207
650    _2
$a potkani transgenní $7 D055647
650    _2
$a receptor endotelinu A $x účinky léků $x metabolismus $7 D044022
650    _2
$a receptor endotelinu B $x účinky léků $x metabolismus $7 D044023
650    _2
$a chronická renální insuficience $x metabolismus $7 D051436
650    _2
$a renin $x účinky léků $x metabolismus $7 D012083
650    _2
$a renin-angiotensin systém $x účinky léků $7 D012084
650    _2
$a míra přežití $7 D015996
655    _2
$a časopisecké články $7 D016428
700    1_
$a Čertíková Chábová, Věra $u c Department of Nephrology, 1st Faculty of Medicine , Charles University , Prague , Czech Republic.
700    1_
$a Doleželová, Šárka $u a Center for Experimental Medicine, Institute for Clinical and Experimental Medicine , Prague , Czech Republic. b Department of Physiology, Faculty of Science , Charles University , Prague , Czech Republic. $7 xx0227631
700    1_
$a Škaroupková, Petra $u a Center for Experimental Medicine, Institute for Clinical and Experimental Medicine , Prague , Czech Republic.
700    1_
$a Kopkan, Libor $u a Center for Experimental Medicine, Institute for Clinical and Experimental Medicine , Prague , Czech Republic.
700    1_
$a Husková, Zuzana $u a Center for Experimental Medicine, Institute for Clinical and Experimental Medicine , Prague , Czech Republic.
700    1_
$a Červenková, Lenka $u a Center for Experimental Medicine, Institute for Clinical and Experimental Medicine , Prague , Czech Republic. f Department of Pathology, 3rd Faculty of Medicine , Charles University , Prague , Czech Republic. $7 xx0227643
700    1_
$a Kikerlová, Soňa $u a Center for Experimental Medicine, Institute for Clinical and Experimental Medicine , Prague , Czech Republic.
700    1_
$a Vaněčková, Ivana $u d Institute of Physiology, v.v.i., Academy of Sciences of the Czech Republic , Prague , Czech Republic.
700    1_
$a Sadowski, Janusz $u e Department of Renal and Body Fluid Physiology , Mossakowski Medical Research Center, Polish Academy of Sciences , Warsaw , Poland.
700    1_
$a Kompanowska-Jezierska, Elzbieta $u e Department of Renal and Body Fluid Physiology , Mossakowski Medical Research Center, Polish Academy of Sciences , Warsaw , Poland.
700    1_
$a Kujal, Petr $u a Center for Experimental Medicine, Institute for Clinical and Experimental Medicine , Prague , Czech Republic. f Department of Pathology, 3rd Faculty of Medicine , Charles University , Prague , Czech Republic.
700    1_
$a Kramer, Herbert J $u g Section of Nephrology, Medical Policlinic, Department of Medicine , University of Bonn , Bonn , Germany.
700    1_
$a Červenka, Luděk $u a Center for Experimental Medicine, Institute for Clinical and Experimental Medicine , Prague , Czech Republic. h Department of Pathophysiology, 2nd Faculty of Medicine , Charles University , Prague , Czech Republic.
773    0_
$w MED00005536 $t Clinical and experimental hypertension (New York, N.Y. 1993) $x 1525-6006 $g Roč. 39, č. 2 (2017), s. 183-195
856    41
$u https://pubmed.ncbi.nlm.nih.gov/28287881 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20170720 $b ABA008
991    __
$a 20220531083153 $b ABA008
999    __
$a ok $b bmc $g 1238895 $s 984127
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2017 $b 39 $c 2 $d 183-195 $e 20170301 $i 1525-6006 $m Clinical and experimental hypertension $n Clin Exp Hypertens $x MED00005536
GRA    __
$a NV15-28671A $p MZ0
LZP    __
$a Pubmed-20170720

Najít záznam

Citační ukazatele

Možnosti archivace