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Self-assembled stable sponge-type nanocarries for Brucea javanica oil delivery
A. Zou, Y. Li, Y. Chen, A. Angelova, VM. Garamus, N. Li, M. Drechsler, B. Angelov, Y. Gong,
Language English Country Netherlands
Document type Journal Article
- MeSH
- Apoptosis drug effects MeSH
- Brucea chemistry MeSH
- Antineoplastic Agents, Phytogenic administration & dosage chemistry pharmacology MeSH
- Humans MeSH
- Cell Line, Tumor MeSH
- Nanoparticles chemistry MeSH
- Drug Carriers chemical synthesis chemistry MeSH
- Oils administration & dosage chemistry pharmacology MeSH
- Surface Properties MeSH
- Cell Proliferation drug effects MeSH
- Drug Screening Assays, Antitumor MeSH
- Particle Size MeSH
- Cell Survival drug effects MeSH
- Dose-Response Relationship, Drug MeSH
- Structure-Activity Relationship MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
Sponge-type nanocarriers (spongosomes) are produced upon dispersion of a liquid crystalline sponge phase formed by self-assembly of an amphiphilic lipid in excess aqueous phase. The inner organization of the spongosomes is built-up by randomly ordered bicontinuous lipid membranes and their surfaces are stabilized by alginate chains providing stealth properties and colloidal stability. The present study elaborates spongosomes for improved encapsulation of Brucea javanica oil (BJO), a traditional Chinese medicine that may strongly inhibit proliferation and metastasis of various cancers. The inner structural organization and the morphology characteristics of BJO-loaded nanocarriers at varying quantities of BJO were determined by cryogenic transmission electron microscopy (Cryo-TEM), small angle X-ray scattering (SAXS) and dynamic light scattering (DLS). Additionally, the drug loading and drug release profiles for BJO-loaded spongosome systems also were determined. We found that the sponge-type liquid crystalline lipid membrane organization provides encapsulation efficiency rate of BJO as high as 90%. In vitro cytotoxicity and apoptosis study of BJO spongosome nanoparticles with A549 cells demonstrated enhanced anti-tumor efficiency. These results suggest potential clinical applications of the obtained safe spongosome formulations.
References provided by Crossref.org
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- $a Zou, Aihua $u Shanghai Key Laboratory of Functional Materials Chemistry, State Key Laboratory of Bioreactor Engineering and Institute of Applied Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, PR China. Electronic address: aihuazou@ecust.edu.cn.
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