• Je něco špatně v tomto záznamu ?

Screening of benzodiazepines in thirty European rivers

J. Fick, T. Brodin, M. Heynen, J. Klaminder, M. Jonsson, K. Grabicova, T. Randak, R. Grabic, V. Kodes, J. Slobodnik, A. Sweetman, M. Earnshaw, A. Barra Caracciolo, T. Lettieri, R. Loos,

. 2017 ; 176 (-) : 324-332. [pub] 20170227

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc17023219

Pharmaceuticals as environmental contaminants have received a lot of interest over the past decade but, for several pharmaceuticals, relatively little is known about their occurrence in European surface waters. Benzodiazepines, a class of pharmaceuticals with anxiolytic properties, have received interest due to their behavioral modifying effect on exposed biota. In this study, our results show the presence of one or more benzodiazepine(s) in 86% of the analyzed surface water samples (n = 138) from 30 rivers, representing seven larger European catchments. Of the 13 benzodiazepines included in the study, we detected 9, which together showed median and mean concentrations (of the results above limit of quantification) of 5.4 and 9.6 ng L(-1), respectively. Four benzodiazepines (oxazepam, temazepam, clobazam, and bromazepam) were the most commonly detected. In particular, oxazepam had the highest frequency of detection (85%) and a maximum concentration of 61 ng L(-1). Temazepam and clobazam were found in 26% (maximum concentration of 39 ng L(-1)) and 14% (maximum concentration of 11 ng L(-1)) of the samples analyzed, respectively. Finally, bromazepam was found only in Germany and in 16 out of total 138 samples (12%), with a maximum concentration of 320 ng L(-1). This study clearly shows that benzodiazepines are common micro-contaminants of the largest European river systems at ng L(-1) levels. Although these concentrations are more than a magnitude lower than those reported to have effective effects on exposed biota, environmental effects cannot be excluded considering the possibility of additive and sub-lethal effects.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc17023219
003      
CZ-PrNML
005      
20170720123512.0
007      
ta
008      
170720s2017 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.chemosphere.2017.02.126 $2 doi
035    __
$a (PubMed)28273540
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Fick, Jerker $u Department of Chemistry, Umeå University, Sweden. Electronic address: jerker.fick@chem.umu.se.
245    10
$a Screening of benzodiazepines in thirty European rivers / $c J. Fick, T. Brodin, M. Heynen, J. Klaminder, M. Jonsson, K. Grabicova, T. Randak, R. Grabic, V. Kodes, J. Slobodnik, A. Sweetman, M. Earnshaw, A. Barra Caracciolo, T. Lettieri, R. Loos,
520    9_
$a Pharmaceuticals as environmental contaminants have received a lot of interest over the past decade but, for several pharmaceuticals, relatively little is known about their occurrence in European surface waters. Benzodiazepines, a class of pharmaceuticals with anxiolytic properties, have received interest due to their behavioral modifying effect on exposed biota. In this study, our results show the presence of one or more benzodiazepine(s) in 86% of the analyzed surface water samples (n = 138) from 30 rivers, representing seven larger European catchments. Of the 13 benzodiazepines included in the study, we detected 9, which together showed median and mean concentrations (of the results above limit of quantification) of 5.4 and 9.6 ng L(-1), respectively. Four benzodiazepines (oxazepam, temazepam, clobazam, and bromazepam) were the most commonly detected. In particular, oxazepam had the highest frequency of detection (85%) and a maximum concentration of 61 ng L(-1). Temazepam and clobazam were found in 26% (maximum concentration of 39 ng L(-1)) and 14% (maximum concentration of 11 ng L(-1)) of the samples analyzed, respectively. Finally, bromazepam was found only in Germany and in 16 out of total 138 samples (12%), with a maximum concentration of 320 ng L(-1). This study clearly shows that benzodiazepines are common micro-contaminants of the largest European river systems at ng L(-1) levels. Although these concentrations are more than a magnitude lower than those reported to have effective effects on exposed biota, environmental effects cannot be excluded considering the possibility of additive and sub-lethal effects.
650    _2
$a benzodiazepiny $x analýza $7 D001569
650    _2
$a monitorování životního prostředí $x metody $7 D004784
650    _2
$a Evropa $7 D005060
650    _2
$a oxazepam $x analýza $7 D010076
650    _2
$a řeky $x chemie $7 D045483
650    _2
$a temazepam $x analýza $7 D013693
650    _2
$a chemické látky znečišťující vodu $x analýza $7 D014874
655    _2
$a časopisecké články $7 D016428
700    1_
$a Brodin, Tomas $u Department of Ecology and Environmental Science, Umeå University, Sweden.
700    1_
$a Heynen, Martina $u Department of Ecology and Environmental Science, Umeå University, Sweden.
700    1_
$a Klaminder, Jonatan $u Department of Ecology and Environmental Science, Umeå University, Sweden.
700    1_
$a Jonsson, Micael $u Department of Ecology and Environmental Science, Umeå University, Sweden.
700    1_
$a Grabicova, Katerina $u Faculty of Fisheries and Protection of Waters, University of South Bohemia in Ceske Budejovice, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Vodnany, Czechia.
700    1_
$a Randak, Tomas $u Faculty of Fisheries and Protection of Waters, University of South Bohemia in Ceske Budejovice, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Vodnany, Czechia.
700    1_
$a Grabic, Roman $u Faculty of Fisheries and Protection of Waters, University of South Bohemia in Ceske Budejovice, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Vodnany, Czechia.
700    1_
$a Kodes, Vit $u Czech Hydrometeorological Institute, Prague, Czechia.
700    1_
$a Slobodnik, Jaroslav $u Environmental Institute, Kos, Slovakia.
700    1_
$a Sweetman, Andrew $u Lancaster Environment Centre, Lancaster University, Lancaster, UK.
700    1_
$a Earnshaw, Mark $u Lancaster Environment Centre, Lancaster University, Lancaster, UK.
700    1_
$a Barra Caracciolo, Anna $u National Research Council, Water Research Institute, Rome, Italy.
700    1_
$a Lettieri, Teresa $u European Commission, Joint Research Centre (JRC), Directorate D - Sustainable Resources, Water and Marine Resources, Ispra, Italy.
700    1_
$a Loos, Robert $u European Commission, Joint Research Centre (JRC), Directorate D - Sustainable Resources, Water and Marine Resources, Ispra, Italy.
773    0_
$w MED00002124 $t Chemosphere $x 1879-1298 $g Roč. 176, č. - (2017), s. 324-332
856    41
$u https://pubmed.ncbi.nlm.nih.gov/28273540 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20170720 $b ABA008
991    __
$a 20170720124005 $b ABA008
999    __
$a ok $b bmc $g 1238900 $s 984132
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2017 $b 176 $c - $d 324-332 $e 20170227 $i 1879-1298 $m Chemosphere $n Chemosphere $x MED00002124
LZP    __
$a Pubmed-20170720

Najít záznam

Citační ukazatele

Možnosti archivace