• Je něco špatně v tomto záznamu ?

Synthesis and Antifungal Screening of 2-{[1-(5-Alkyl/arylalkylpyrazin-2-yl)ethylidene]hydrazono}-1,3-thiazolidin-4-ones

V. Opletalova, J. Dolezel, J. Kunes, V. Buchta, M. Vejsova, M. Kucerova-Chlupacova,

. 2016 ; 21 (11) : . [pub] 20161123

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc17023476

Two novel thiosemicarbazones and eight novel 2-{[1-(5-alkyl/arylalkylpyrazin-2-yl)ethylidene]hydrazono}-1,3-thiazolidin-4-ones were prepared and tested against a panel of eight fungal strains-Candida albicans ATCC 44859, Candida tropicalis 156, Candida krusei E 28, Candida glabrata 20/I, Trichosporon asahii 1188, Aspergillus fumigatus 231, Lichtheimia corymbifera 272, and Trichophyton interdigitale 445. 1,3-Thiazolidin-4-ones exhibited activity against all strains, the most potent derivative was 2-{[1-(5-butylpyrazin-2-yl)ethylidene]hydrazono}e-1,3-thiazolidin-4-one. Susceptibility of C. glabrata to the studied 1,3-thiazolidin-4-ones (minimum inhibitory concentrations (MICs) were in the range 0.57 to 2.78 mg/L) is of great interest as this opportunistic pathogen is poorly susceptible to azoles and becomes resistant to echinocandins. Antifungal potency of thiosemicarbazones was slightly lower than that of 1,3-thiazolidin-4-ones.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc17023476
003      
CZ-PrNML
005      
20170720124152.0
007      
ta
008      
170720s2016 sz f 000 0|eng||
009      
AR
024    7_
$a 10.3390/molecules21111592 $2 doi
035    __
$a (PubMed)27886119
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Opletalova, Veronika $u Department of Pharmaceutical Chemistry and Pharmaceutical Analysis, Faculty of Pharmacy in Hradec Kralove, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic. opletalova@faf.cuni.cz.
245    10
$a Synthesis and Antifungal Screening of 2-{[1-(5-Alkyl/arylalkylpyrazin-2-yl)ethylidene]hydrazono}-1,3-thiazolidin-4-ones / $c V. Opletalova, J. Dolezel, J. Kunes, V. Buchta, M. Vejsova, M. Kucerova-Chlupacova,
520    9_
$a Two novel thiosemicarbazones and eight novel 2-{[1-(5-alkyl/arylalkylpyrazin-2-yl)ethylidene]hydrazono}-1,3-thiazolidin-4-ones were prepared and tested against a panel of eight fungal strains-Candida albicans ATCC 44859, Candida tropicalis 156, Candida krusei E 28, Candida glabrata 20/I, Trichosporon asahii 1188, Aspergillus fumigatus 231, Lichtheimia corymbifera 272, and Trichophyton interdigitale 445. 1,3-Thiazolidin-4-ones exhibited activity against all strains, the most potent derivative was 2-{[1-(5-butylpyrazin-2-yl)ethylidene]hydrazono}e-1,3-thiazolidin-4-one. Susceptibility of C. glabrata to the studied 1,3-thiazolidin-4-ones (minimum inhibitory concentrations (MICs) were in the range 0.57 to 2.78 mg/L) is of great interest as this opportunistic pathogen is poorly susceptible to azoles and becomes resistant to echinocandins. Antifungal potency of thiosemicarbazones was slightly lower than that of 1,3-thiazolidin-4-ones.
650    _2
$a antifungální látky $x chemická syntéza $x chemie $x farmakologie $7 D000935
650    _2
$a Aspergillus $x účinky léků $7 D001230
650    _2
$a Candida $x účinky léků $7 D002175
650    _2
$a mikrobiální testy citlivosti $7 D008826
650    _2
$a molekulární struktura $7 D015394
650    _2
$a Mucorales $x účinky léků $7 D009090
650    _2
$a thiazolidindiony $x chemická syntéza $x chemie $x farmakologie $7 D045162
650    _2
$a thiosemikarbazony $x chemická syntéza $x chemie $x farmakologie $7 D013882
650    _2
$a Trichophyton $x účinky léků $7 D014249
655    _2
$a časopisecké články $7 D016428
700    1_
$a Dolezel, Jan $u GlaxoSmithKline, Hvezdova 1734/2c, 140 00 Prague, Czech Republic. jan.j.dolezel@gsk.com.
700    1_
$a Kunes, Jiri $u Department of Inorganic and Organic Chemistry, Faculty of Pharmacy in Hradec Kralove, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic. kunes@faf.cuni.cz.
700    1_
$a Buchta, Vladimir $u Department of Biological and Medical Sciences, Faculty of Pharmacy in Hradec Kralove, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic. buchta@faf.cuni.cz. Department of Clinical Microbiology, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic. buchta@faf.cuni.cz.
700    1_
$a Vejsova, Marcela $u Department of Biological and Medical Sciences, Faculty of Pharmacy in Hradec Kralove, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic. vejsova@faf.cuni.cz. Department of Clinical Microbiology, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic. vejsova@faf.cuni.cz.
700    1_
$a Kucerova-Chlupacova, Marta $u Department of Pharmaceutical Chemistry and Pharmaceutical Analysis, Faculty of Pharmacy in Hradec Kralove, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic. kucerom@faf.cuni.cz.
773    0_
$w MED00180394 $t Molecules (Basel, Switzerland) $x 1420-3049 $g Roč. 21, č. 11 (2016)
856    41
$u https://pubmed.ncbi.nlm.nih.gov/27886119 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20170720 $b ABA008
991    __
$a 20170720124645 $b ABA008
999    __
$a ok $b bmc $g 1239157 $s 984389
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2016 $b 21 $c 11 $e 20161123 $i 1420-3049 $m Molecules $n Molecules $x MED00180394
LZP    __
$a Pubmed-20170720

Najít záznam

Citační ukazatele

Možnosti archivace