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Needleless coaxial electrospinning: A novel approach to mass production of coaxial nanofibers

L. Vysloužilová, M. Buzgo, P. Pokorný, J. Chvojka, A. Míčková, M. Rampichová, J. Kula, K. Pejchar, M. Bílek, D. Lukáš, E. Amler,

. 2017 ; 516 (1-2) : 293-300. [pub] 20161113

Language English Country Netherlands

Document type Journal Article

Grant support
NV16-29680A MZ0 CEP Register
NV16-29680A MZ0 CEP Register

Herein, we describe a simple spinneret setup for needleless coaxial electrospinning that exceeds the limited production capacity of current approaches. The proposed weir spinneret enables coaxial electrospinning from free liquid surface. This approach leads to the formation of coaxial nanofibers with higher and uniform shell/core ratio, which results in the possibility of better tuning of the degradation rate. The throughput and quality increase favor the broader application of coaxial nanofibers from weir spinnerets as systems for controlled drug delivery in regenerative medicine and tissue engineering.

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$a Vysloužilová, Lucie $u Department of Nonwovens, Technical University of Liberec Studentska 2, 461 17 Liberec, Czechia.
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$a Herein, we describe a simple spinneret setup for needleless coaxial electrospinning that exceeds the limited production capacity of current approaches. The proposed weir spinneret enables coaxial electrospinning from free liquid surface. This approach leads to the formation of coaxial nanofibers with higher and uniform shell/core ratio, which results in the possibility of better tuning of the degradation rate. The throughput and quality increase favor the broader application of coaxial nanofibers from weir spinnerets as systems for controlled drug delivery in regenerative medicine and tissue engineering.
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$a Buzgo, Matej $u Department of Biophysics, 2nd Faculty of Medicine, Charles University in Prague, V Úvalu 84, 150 06, Prague 5, Czechia; Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, v.v.i., Vídeňská 1083, 142 20, Prague 4, Czechia; University Centre for Energy Efiicient Buildings, Czech Technical University in Prague, Trinecka 1024, 273 43, Bustehrad, Czechia. Electronic address: buzgo@labdemo.cz.
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$a Pokorný, Pavel $u Department of Nonwovens, Technical University of Liberec Studentska 2, 461 17 Liberec, Czechia.
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$a Chvojka, Jiří $u Department of Nonwovens, Technical University of Liberec Studentska 2, 461 17 Liberec, Czechia.
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$a Míčková, Andrea $u Department of Biophysics, 2nd Faculty of Medicine, Charles University in Prague, V Úvalu 84, 150 06, Prague 5, Czechia; Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, v.v.i., Vídeňská 1083, 142 20, Prague 4, Czechia; University Centre for Energy Efiicient Buildings, Czech Technical University in Prague, Trinecka 1024, 273 43, Bustehrad, Czechia.
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$a Rampichová, Michala $u Department of Biophysics, 2nd Faculty of Medicine, Charles University in Prague, V Úvalu 84, 150 06, Prague 5, Czechia; Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, v.v.i., Vídeňská 1083, 142 20, Prague 4, Czechia; University Centre for Energy Efiicient Buildings, Czech Technical University in Prague, Trinecka 1024, 273 43, Bustehrad, Czechia.
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$a Kula, Jiří $u Department of Textile Evaluation, Technical University of Liberec, Studentska 2, 461 17 Liberec, Czechia.
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$a Pejchar, Karel $u Department of Textile Machine Design, Technical University of Liberec, Studentska 2, 461 17 Liberec, Czechia.
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$a Bílek, Martin $u Department of Textile Machine Design, Technical University of Liberec, Studentska 2, 461 17 Liberec, Czechia.
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$a Lukáš, David $u Department of Nonwovens, Technical University of Liberec Studentska 2, 461 17 Liberec, Czechia.
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$a Amler, Evžen, $u Department of Biophysics, 2nd Faculty of Medicine, Charles University in Prague, V Úvalu 84, 150 06, Prague 5, Czechia; Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, v.v.i., Vídeňská 1083, 142 20, Prague 4, Czechia; University Centre for Energy Efiicient Buildings, Czech Technical University in Prague, Trinecka 1024, 273 43, Bustehrad, Czechia. $d 1958- $7 xx0014074 $4
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