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Combined Analysis of Variation in Core, Accessory and Regulatory Genome Regions Provides a Super-Resolution View into the Evolution of Bacterial Populations
A. McNally, Y. Oren, D. Kelly, B. Pascoe, S. Dunn, T. Sreecharan, M. Vehkala, N. Välimäki, MB. Prentice, A. Ashour, O. Avram, T. Pupko, U. Dobrindt, I. Literak, S. Guenther, K. Schaufler, LH. Wieler, Z. Zhiyong, SK. Sheppard, JO. McInerney, J. Corander,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
NLK
Directory of Open Access Journals
od 2005
Free Medical Journals
od 2005
Public Library of Science (PLoS)
od 2005-07-01
PubMed Central
od 2005
Europe PubMed Central
od 2005
ProQuest Central
od 2005-07-01
Open Access Digital Library
od 2005-07-01
Open Access Digital Library
od 2005-01-01
Open Access Digital Library
od 2005-01-01
Medline Complete (EBSCOhost)
od 2005-07-01
Health & Medicine (ProQuest)
od 2005-07-01
- MeSH
- antibiotická rezistence genetika MeSH
- Escherichia coli genetika patogenita MeSH
- fylogeneze MeSH
- genom bakteriální účinky léků MeSH
- infekce vyvolané Escherichia coli farmakoterapie genetika MeSH
- lidé MeSH
- molekulární evoluce * MeSH
- regulační oblasti nukleových kyselin genetika MeSH
- sekvenční analýza DNA MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
The use of whole-genome phylogenetic analysis has revolutionized our understanding of the evolution and spread of many important bacterial pathogens due to the high resolution view it provides. However, the majority of such analyses do not consider the potential role of accessory genes when inferring evolutionary trajectories. Moreover, the recently discovered importance of the switching of gene regulatory elements suggests that an exhaustive analysis, combining information from core and accessory genes with regulatory elements could provide unparalleled detail of the evolution of a bacterial population. Here we demonstrate this principle by applying it to a worldwide multi-host sample of the important pathogenic E. coli lineage ST131. Our approach reveals the existence of multiple circulating subtypes of the major drug-resistant clade of ST131 and provides the first ever population level evidence of core genome substitutions in gene regulatory regions associated with the acquisition and maintenance of different accessory genome elements.
Centre for Infectious Diseases West China Hospital of Sichuan University Chengdu China
College of Medicine University of Swansea Swansea United Kingdom
Department of Biology National University Ireland Maynooth Ireland
Department of Mathematics and Statistics University of Helsinki Helsinki Finland
Departments of Pathology and Microbiology University College Cork Cork Ireland
Institute of Hygiene Universitat Muenster Muenster Germany
Pathogen Research Group Nottingham Trent University Nottingham United Kingdom
Citace poskytuje Crossref.org
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