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Epidermal Growth Factor Attenuates Delayed Ionizing Radiation-Induced Tissue Damage in Bone Marrow Transplanted Mice
J. Pejchal, Z. Sinkorova, A. Tichy, S. Pruchova, A. Kmochova, K. Durisova, L. Cechakova, A. Lierova, M. Ondrej, M. Nemcova, K. Kubelkova, I. Fatorova, J. Bures, I. Tacheci, K. Kuca, J. Vavrova,
Language English Country United States
Document type Journal Article
NLK
ProQuest Central
from 2012-09-01 to 2016-11-30
Medline Complete (EBSCOhost)
from 2011-08-01 to 6 months ago
Nursing & Allied Health Database (ProQuest)
from 2012-09-01 to 2016-11-30
Health & Medicine (ProQuest)
from 2012-09-01 to 2016-11-30
PubMed
27538113
DOI
10.1667/rr14247.1
Knihovny.cz E-resources
- MeSH
- Apoptosis drug effects radiation effects MeSH
- Safety MeSH
- Time Factors MeSH
- Whole-Body Irradiation adverse effects MeSH
- Cytokines blood MeSH
- EGF Family of Proteins pharmacology MeSH
- Bone Marrow drug effects immunology radiation effects MeSH
- Mitosis drug effects radiation effects MeSH
- Mice MeSH
- Cell Count MeSH
- Radiation Injuries blood drug therapy pathology therapy MeSH
- Spleen drug effects pathology radiation effects MeSH
- Intestines drug effects pathology radiation effects MeSH
- Bone Marrow Transplantation * MeSH
- Organ Size drug effects radiation effects MeSH
- Dose-Response Relationship, Radiation MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
We examined the effect of epidermal growth factor (EGF) treatment in mice that received bone marrow transplantation (BMT) after 11 Gy whole-body irradiation. C57Bl/6 mice were divided into three treatment groups: 0 Gy; 11 Gy ((60)Co, single dose, 0.51 Gy/min) with BMT (5 × 10(6) bone marrow cells isolated from green fluorescent protein syngeneic mice, 3-4 h postirradiation); and 11 Gy with BMT and EGF (2 mg/kg applied subcutaneously 1, 3 and 5 days postirradiation). Survival data were collected. Bone marrow, peripheral blood count and cytokines, gastrointestine and liver parameters and migration of green fluorescent protein-positive cells were evaluated at 63 days postirradiation. Epidermal growth factor increased survival of irradiated animals that received BMT from 10.7 to 85.7% at 180 days postirradiation. In the BMT group, we found changes in differential bone marrow and blood count, plasma cytokine levels, gastrointestinal tissues and liver at 63 days postirradiation. These alterations were completely or in some parameters at least partially restored by epidermal growth factor. These findings indicate that epidermal growth factor, administered 1, 3 and 5 days postirradiation in combination with bone marrow transplantation, significantly improves long-term prognosis.
c 4th Department of Internal Medicine Haematology and
e Biomedical Reseach Centre University Hospital Hradec Kralove Czech Republic
Radiobiology and e Biomedical Reseach Centre University Hospital Hradec Kralove Czech Republic
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- $a We examined the effect of epidermal growth factor (EGF) treatment in mice that received bone marrow transplantation (BMT) after 11 Gy whole-body irradiation. C57Bl/6 mice were divided into three treatment groups: 0 Gy; 11 Gy ((60)Co, single dose, 0.51 Gy/min) with BMT (5 × 10(6) bone marrow cells isolated from green fluorescent protein syngeneic mice, 3-4 h postirradiation); and 11 Gy with BMT and EGF (2 mg/kg applied subcutaneously 1, 3 and 5 days postirradiation). Survival data were collected. Bone marrow, peripheral blood count and cytokines, gastrointestine and liver parameters and migration of green fluorescent protein-positive cells were evaluated at 63 days postirradiation. Epidermal growth factor increased survival of irradiated animals that received BMT from 10.7 to 85.7% at 180 days postirradiation. In the BMT group, we found changes in differential bone marrow and blood count, plasma cytokine levels, gastrointestinal tissues and liver at 63 days postirradiation. These alterations were completely or in some parameters at least partially restored by epidermal growth factor. These findings indicate that epidermal growth factor, administered 1, 3 and 5 days postirradiation in combination with bone marrow transplantation, significantly improves long-term prognosis.
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