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Expansion of Signal Transduction Pathways in Fungi by Extensive Genome Duplication
LM. Corrochano, A. Kuo, M. Marcet-Houben, S. Polaino, A. Salamov, JM. Villalobos-Escobedo, J. Grimwood, MI. Álvarez, J. Avalos, D. Bauer, EP. Benito, I. Benoit, G. Burger, LP. Camino, D. Cánovas, E. Cerdá-Olmedo, JF. Cheng, A. Domínguez, M....
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články
Perzistentní odkaz
https://www.medvik.cz/link/bmc17023947
Online
Plný text
NLK
Cell Press Free Archives
od 1995-01-01 do Před 1 rokem
Free Medical Journals
od 1995 do Před 1 rokem
- MeSH
- duplikace genu * MeSH
- genetická transkripce účinky záření MeSH
- genom fungální * MeSH
- molekulární evoluce * MeSH
- Mucor genetika účinky záření MeSH
- multigenová rodina MeSH
- percepce MeSH
- Phycomyces genetika účinky záření MeSH
- signální transdukce genetika MeSH
- světlo MeSH
- Publikační typ
- časopisecké články MeSH
Plants and fungi use light and other signals to regulate development, growth, and metabolism. The fruiting bodies of the fungus Phycomyces blakesleeanus are single cells that react to environmental cues, including light, but the mechanisms are largely unknown [1]. The related fungus Mucor circinelloides is an opportunistic human pathogen that changes its mode of growth upon receipt of signals from the environment to facilitate pathogenesis [2]. Understanding how these organisms respond to environmental cues should provide insights into the mechanisms of sensory perception and signal transduction by a single eukaryotic cell, and their role in pathogenesis. We sequenced the genomes of P. blakesleeanus and M. circinelloides and show that they have been shaped by an extensive genome duplication or, most likely, a whole-genome duplication (WGD), which is rarely observed in fungi [3-6]. We show that the genome duplication has expanded gene families, including those involved in signal transduction, and that duplicated genes have specialized, as evidenced by differences in their regulation by light. The transcriptional response to light varies with the developmental stage and is still observed in a photoreceptor mutant of P. blakesleeanus. A phototropic mutant of P. blakesleeanus with a heterozygous mutation in the photoreceptor gene madA demonstrates that photosensor dosage is important for the magnitude of signal transduction. We conclude that the genome duplication provided the means to improve signal transduction for enhanced perception of environmental signals. Our results will help to understand the role of genome dynamics in the evolution of sensory perception in eukaryotes.
Centre for Genomic Regulation Doctor Aiguader 88 08003 Barcelona Spain
Departamento de Genética y Microbiología Universidad de Murcia 30071 Murcia Spain
Department of Agrarian Production Public University of Navarre 31006 Pamplona Spain
Department of Biological Sciences King Abdulaziz University P O Box 80203 Jeddah 21589 Saudi Arabia
Department of Biology Technion Israel Institute of Technology Haifa 32000 Israel
Department of Biology University of Florida P O Box 118525 Gainesville FL 32611 8525 USA
Department of Genetics University of Seville Avenida Reina Mercedes s n 41012 Seville Spain
Genome Analysis Platform CIC bioGUNE Bizkaia Technology Park 48160 Derio Bizkaia Spain
HudsonAlpha Institute of Biotechnology 601 Genome Way Northwest Huntsville AL 35806 USA
Institució Catalana de Recerca i Estudis Avançats 08010 Barcelona Spain
Pacific Northwest National Laboratory 902 Battelle Boulevard Richland WA 99352 USA
School of BioSciences University of Melbourne Melbourne VIC 3010 Australia
Universitat Pompeu Fabra Doctor Aiguader 88 08003 Barcelona Spain
US Department of Energy Joint Genome Institute 2800 Mitchell Drive Walnut Creek CA 94598 USA
Citace poskytuje Crossref.org
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- $a Corrochano, Luis M $u Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain. Electronic address: corrochano@us.es.
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- $a Expansion of Signal Transduction Pathways in Fungi by Extensive Genome Duplication / $c LM. Corrochano, A. Kuo, M. Marcet-Houben, S. Polaino, A. Salamov, JM. Villalobos-Escobedo, J. Grimwood, MI. Álvarez, J. Avalos, D. Bauer, EP. Benito, I. Benoit, G. Burger, LP. Camino, D. Cánovas, E. Cerdá-Olmedo, JF. Cheng, A. Domínguez, M. Eliáš, AP. Eslava, F. Glaser, G. Gutiérrez, J. Heitman, B. Henrissat, EA. Iturriaga, BF. Lang, JL. Lavín, SC. Lee, W. Li, E. Lindquist, S. López-García, EM. Luque, AT. Marcos, J. Martin, K. McCluskey, HR. Medina, A. Miralles-Durán, A. Miyazaki, E. Muñoz-Torres, JA. Oguiza, RA. Ohm, M. Olmedo, M. Orejas, L. Ortiz-Castellanos, AG. Pisabarro, J. Rodríguez-Romero, J. Ruiz-Herrera, R. Ruiz-Vázquez, C. Sanz, W. Schackwitz, M. Shahriari, E. Shelest, F. Silva-Franco, D. Soanes, K. Syed, VG. Tagua, NJ. Talbot, MR. Thon, H. Tice, RP. de Vries, A. Wiebenga, JS. Yadav, EL. Braun, SE. Baker, V. Garre, J. Schmutz, BA. Horwitz, S. Torres-Martínez, A. Idnurm, A. Herrera-Estrella, T. Gabaldón, IV. Grigoriev,
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