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The Role of Xenobiotic-Metabolizing Enzymes in Anthelmintic Deactivation and Resistance in Helminths
P. Matoušková, I. Vokřál, J. Lamka, L. Skálová,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, přehledy
PubMed
26968642
DOI
10.1016/j.pt.2016.02.004
Knihovny.cz E-zdroje
- MeSH
- anthelmintika metabolismus farmakologie MeSH
- cizopasní červi účinky léků enzymologie MeSH
- genom u helmintů genetika MeSH
- interakce hostitele a parazita genetika MeSH
- léková rezistence genetika MeSH
- proteiny červů genetika metabolismus MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Xenobiotic-metabolizing enzymes (XMEs) modulate the biological activity and behavior of many drugs, including anthelmintics. The effects of anthelmintics can often be abolished by XMEs when the drugs are metabolized to an inefficient compound. XMEs therefore play a significant role in anthelmintic efficacy. Moreover, differences in XMEs between helminths are reflected by differences in anthelmintic metabolism between target species. Taking advantage of the newly sequenced genomes of many helminth species, progress in this field has been remarkable. The present review collects up to date information regarding the most important XMEs (phase I and phase II biotransformation enzymes; efflux transporters) in helminths. The participation of these XMEs in anthelmintic metabolism and their possible roles in drug resistance are evaluated.
Citace poskytuje Crossref.org
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