• Je něco špatně v tomto záznamu ?

Spontaneous Closure of Patent Ductus Arteriosus in Infants ≤1500 g

J. Semberova, J. Sirc, J. Miletin, J. Kucera, I. Berka, S. Sebkova, S. O'Sullivan, O. Franklin, Z. Stranak,

. 2017 ; 140 (2) : . [pub] 20170712

Jazyk angličtina Země Spojené státy americké

Typ dokumentu srovnávací studie, časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc17030693

OBJECTIVES: Patent ductus arteriosus (PDA) remains a challenging issue in very low birth weight (VLBW) infants, and its management varies widely. Our aim in this study was to document the natural course of ductus arteriosus in a cohort of VLBW infants who underwent conservative PDA management with no medical or surgical intervention. METHODS: A retrospective cohort study conducted in 2 European level-3 neonatal units. RESULTS: A total of 368 VLBW infants were born within the study period. Two hundred and ninety-seven infants were free of congenital malformations or heart defects and survived to hospital discharge. Out of those, 280 infants received truly conservative PDA management. In 237 (85%) of nontreated infants, the PDA closed before hospital discharge. The Kaplan-Meier model was used to document the incidence proportion of PDA closure over time for different gestational age groups. The median time to ductal closure was 71, 13, 8, and 6 days in <26+0, 26+0 to 27+6, 28+0 to 29+6, and ≥30 weeks, respectively. For different birth weight groups, the median was 48, 22, 9, and 8 days in infants weighing <750, 750 to 999, 1000 to 1249, and 1250 to 1500 g, respectively. No statistically significant relationship was found between PDA closure before hospital discharge and neonatal morbidities. CONCLUSIONS: The likelihood of PDA spontaneous closure in VLBW infants is extremely high. We provide in our findings a platform for future placebo-controlled trials focused on the smallest and youngest infants.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc17030693
003      
CZ-PrNML
005      
20171102130154.0
007      
ta
008      
171025s2017 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1542/peds.2016-4258 $2 doi
035    __
$a (PubMed)28701390
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Semberova, Jana $u Department of Neonatology, Coombe Women and Infants Hospital, Dublin, Ireland. Institute for the Care of Mother and Child, Prague, Czech Republic.
245    10
$a Spontaneous Closure of Patent Ductus Arteriosus in Infants ≤1500 g / $c J. Semberova, J. Sirc, J. Miletin, J. Kucera, I. Berka, S. Sebkova, S. O'Sullivan, O. Franklin, Z. Stranak,
520    9_
$a OBJECTIVES: Patent ductus arteriosus (PDA) remains a challenging issue in very low birth weight (VLBW) infants, and its management varies widely. Our aim in this study was to document the natural course of ductus arteriosus in a cohort of VLBW infants who underwent conservative PDA management with no medical or surgical intervention. METHODS: A retrospective cohort study conducted in 2 European level-3 neonatal units. RESULTS: A total of 368 VLBW infants were born within the study period. Two hundred and ninety-seven infants were free of congenital malformations or heart defects and survived to hospital discharge. Out of those, 280 infants received truly conservative PDA management. In 237 (85%) of nontreated infants, the PDA closed before hospital discharge. The Kaplan-Meier model was used to document the incidence proportion of PDA closure over time for different gestational age groups. The median time to ductal closure was 71, 13, 8, and 6 days in <26+0, 26+0 to 27+6, 28+0 to 29+6, and ≥30 weeks, respectively. For different birth weight groups, the median was 48, 22, 9, and 8 days in infants weighing <750, 750 to 999, 1000 to 1249, and 1250 to 1500 g, respectively. No statistically significant relationship was found between PDA closure before hospital discharge and neonatal morbidities. CONCLUSIONS: The likelihood of PDA spontaneous closure in VLBW infants is extremely high. We provide in our findings a platform for future placebo-controlled trials focused on the smallest and youngest infants.
650    _2
$a kohortové studie $7 D015331
650    _2
$a konzervativní terapie $7 D000072700
650    _2
$a Česká republika $7 D018153
650    _2
$a otevřená tepenná dučej $x diagnóza $x mortalita $x terapie $7 D004374
650    _2
$a echokardiografie $7 D004452
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a následné studie $7 D005500
650    _2
$a gestační stáří $7 D005865
650    _2
$a mortalita v nemocnicích $7 D017052
650    _2
$a lidé $7 D006801
650    _2
$a kojenec $7 D007223
650    _2
$a novorozenec $7 D007231
650    12
$a novorozenec s velmi nízkou porodní hmotností $7 D019102
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a propuštění pacienta $7 D010351
650    _2
$a spontánní remise $7 D012075
650    _2
$a retrospektivní studie $7 D012189
655    _2
$a srovnávací studie $7 D003160
655    _2
$a časopisecké články $7 D016428
700    1_
$a Sirc, Jan $u Institute for the Care of Mother and Child, Prague, Czech Republic. Third Faculty of Medicine, Charles University, Prague, Czech Republic.
700    1_
$a Miletin, Jan $u Department of Neonatology, Coombe Women and Infants Hospital, Dublin, Ireland; miletinj@yahoo.com. Institute for the Care of Mother and Child, Prague, Czech Republic. Third Faculty of Medicine, Charles University, Prague, Czech Republic. UCD School of Medicine and Medical Sciences, Dublin, Ireland; and.
700    1_
$a Kucera, Jachym $u Institute for the Care of Mother and Child, Prague, Czech Republic.
700    1_
$a Berka, Ivan $u Institute for the Care of Mother and Child, Prague, Czech Republic.
700    1_
$a Sebkova, Sylva $u Institute for the Care of Mother and Child, Prague, Czech Republic.
700    1_
$a O'Sullivan, Sinead $u Department of Neonatology, Coombe Women and Infants Hospital, Dublin, Ireland.
700    1_
$a Franklin, Orla $u Department of Paediatric Cardiology, Our Lady's Children's Hospital Crumlin, Dublin, Ireland.
700    1_
$a Stranak, Zbynek $u Institute for the Care of Mother and Child, Prague, Czech Republic. Third Faculty of Medicine, Charles University, Prague, Czech Republic.
773    0_
$w MED00003743 $t Pediatrics $x 1098-4275 $g Roč. 140, č. 2 (2017)
856    41
$u https://pubmed.ncbi.nlm.nih.gov/28701390 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20171025 $b ABA008
991    __
$a 20171102130247 $b ABA008
999    __
$a ok $b bmc $g 1254286 $s 991720
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2017 $b 140 $c 2 $e 20170712 $i 1098-4275 $m Pediatrics $n Pediatrics $x MED00003743
LZP    __
$a Pubmed-20171025
Zpět

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace