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Intertumoral Heterogeneity within Medulloblastoma Subgroups
FMG. Cavalli, M. Remke, L. Rampasek, J. Peacock, DJH. Shih, B. Luu, L. Garzia, J. Torchia, C. Nor, AS. Morrissy, S. Agnihotri, YY. Thompson, CM. Kuzan-Fischer, H. Farooq, K. Isaev, C. Daniels, BK. Cho, SK. Kim, KC. Wang, JY. Lee, WA. Grajkowska,...
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
NLK
Cell Press Free Archives
od 2002-02-01 do Před 1 rokem
Free Medical Journals
od 2002 do Před 1 rokem
- MeSH
- genomika MeSH
- individualizovaná medicína * MeSH
- kohortové studie MeSH
- lidé MeSH
- meduloblastom klasifikace genetika terapie MeSH
- metylace DNA MeSH
- shluková analýza MeSH
- stanovení celkové genové exprese MeSH
- variabilita počtu kopií segmentů DNA MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
While molecular subgrouping has revolutionized medulloblastoma classification, the extent of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to genome-wide DNA methylation and gene expression data across 763 primary samples identifies very homogeneous clusters of patients, supporting the presence of medulloblastoma subtypes. After integration of somatic copy-number alterations, and clinical features specific to each cluster, we identify 12 different subtypes of medulloblastoma. Integrative analysis using SNF further delineates group 3 from group 4 medulloblastoma, which is not as readily apparent through analyses of individual data types. Two clear subtypes of infants with Sonic Hedgehog medulloblastoma with disparate outcomes and biology are identified. Medulloblastoma subtypes identified through integrative clustering have important implications for stratification of future clinical trials.
2nd Department of Pediatrics Semmelweis University Budapest 1094 Hungary
Banting and Best Department of Medical Research University of Toronto Toronto ON M5G 1L6 Canada
Centre de Pathologie EST Groupement Hospitalier EST Université de Lyon Bron 69677 France
Clinical Research Division Fred Hutchinson Cancer Research Center Seattle WA 98109 1024 USA
Department of Computer Science University of Toronto Toronto ON M5S 2E4 Canada
Department of Laboratory Medicine and Pathobiology University of Toronto Toronto ON M5S 1A1 Canada
Department of Laboratory Medicine and Pathology Mayo Clinic Rochester MN 55905 USA
Department of Medical Biophysics University of Toronto Toronto ON M5G 1L7 Canada
Department of Molecular Genetics University of Toronto Toronto ON M5S 1A8 Canada
Department of Neuro Oncology Istituto Neurologico Besta Milan 20133 Italy
Department of Neurological Surgery Vanderbilt Medical Center Nashville TN 37232 USA
Department of Neurology Erasmus University Medical Center Rotterdam 3015 CE the Netherlands
Department of Neurology Vanderbilt Medical Center Nashville TN 37232 USA
Department of Neurosurgery David Geffen School of Medicine at UCLA Los Angeles CA 90095 USA
Department of Neurosurgery Erasmus University Medical Center Rotterdam 3015 CE the Netherlands
Department of Neurosurgery Hospital Infantil de Mexico Federico Gomez Mexico City 06720 Mexico
Department of Neurosurgery Kitasato University School of Medicine Sagamihara Kanagawa 252 0374 Japan
Department of Neurosurgery University of Ulsan Asan Medical Center Seoul 05505 South Korea
Department of Pathology and Laboratory Medicine Hamilton General Hospital Hamilton ON L8L 2X2 Canada
Department of Pathology and Laboratory Medicine University of Calgary Calgary AB T2N 2T9 Canada
Department of Pathology Erasmus University Medical Center Rotterdam 3015 CN the Netherlands
Department of Pathology Hospital Infantil de Mexico Federico Gomez Mexico City 06720 Mexico
Department of Pathology McGill University Montreal QC H4A 3J1 Canada
Department of Pathology Montreal Children's Hospital Montreal QC H4A 3J1 Canada
Department of Pathology University of Arkansas for Medical Sciences Little Rock AR 72205 USA
Department of Pathology University of Pittsburgh School of Medicine Pittsburgh PA 15261 USA
Department of Pediatric Neuro Oncogenomics German Cancer Consortium Düsseldorf 40225 Germany
Department of Pediatric Neurosurgery Catholic University Medical School Rome 00198 Italy
Department of Pediatric Oncology School of Medicine Masaryk University Brno 625 00 Czech Republic
Department of Pediatrics University of Colorado Denver Aurora CO 80045 USA
Developmental and Stem Cell Biology Program The Hospital for Sick Children Toronto ON M5G 1X8 Canada
Dipartimento di Biochimica e Biotecnologie Mediche University of Naples Naples 80145 Italy
Division of Haematology Oncology The Hospital for Sick Children Toronto ON M5G 1X8 Canada
Division of Neurosurgery The Hospital for Sick Children Toronto ON M5G 1X8 Canada
Division of Pathology The Hospital for Sick Children Toronto ON M5G 1X8 Canada
Division of Pediatric Hematology Oncology Mayo Clinic Rochester MN 55905 USA
Divison of Pathology Centro Hospitalar Lisboa Norte Hospital de Santa Maria Lisbon 1649 035 Portugal
Fondazione IRCCS Istituto Nazionale Tumori Milan 20133 Italy
Informatics Program Ontario Institute for Cancer Research Toronto ON M5G 0A3 Canada
Institute of Pediatric Hematology and Oncology Lyon 69008 France
Kolling Institute of Medical Research The University of Sydney Sydney NSW 2065 Australia
Lady Cilento Children's Hospital The University of Queensland Brisbane QLD 4102 Australia
McLaughlin Centre University of Toronto Toronto ON M5G 0A4 Canada
Program in Genetics and Genome Biology The Hospital for Sick Children Toronto ON M5G 1X8 Canada
The Donnelly Centre University of Toronto Toronto ON M5S 3E1 Canada
Citace poskytuje Crossref.org
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- $a Cavalli, Florence M G $u The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
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- $a Intertumoral Heterogeneity within Medulloblastoma Subgroups / $c FMG. Cavalli, M. Remke, L. Rampasek, J. Peacock, DJH. Shih, B. Luu, L. Garzia, J. Torchia, C. Nor, AS. Morrissy, S. Agnihotri, YY. Thompson, CM. Kuzan-Fischer, H. Farooq, K. Isaev, C. Daniels, BK. Cho, SK. Kim, KC. Wang, JY. Lee, WA. Grajkowska, M. Perek-Polnik, A. Vasiljevic, C. Faure-Conter, A. Jouvet, C. Giannini, AA. Nageswara Rao, KKW. Li, HK. Ng, CG. Eberhart, IF. Pollack, RL. Hamilton, GY. Gillespie, JM. Olson, S. Leary, WA. Weiss, B. Lach, LB. Chambless, RC. Thompson, MK. Cooper, R. Vibhakar, P. Hauser, MC. van Veelen, JM. Kros, PJ. French, YS. Ra, T. Kumabe, E. López-Aguilar, K. Zitterbart, J. Sterba, G. Finocchiaro, M. Massimino, EG. Van Meir, S. Osuka, T. Shofuda, A. Klekner, M. Zollo, JR. Leonard, JB. Rubin, N. Jabado, S. Albrecht, J. Mora, TE. Van Meter, S. Jung, AS. Moore, AR. Hallahan, JA. Chan, DPC. Tirapelli, CG. Carlotti, M. Fouladi, J. Pimentel, CC. Faria, AG. Saad, L. Massimi, LM. Liau, H. Wheeler, H. Nakamura, SK. Elbabaa, M. Perezpeña-Diazconti, F. Chico Ponce de León, S. Robinson, M. Zapotocky, A. Lassaletta, A. Huang, CE. Hawkins, U. Tabori, E. Bouffet, U. Bartels, PB. Dirks, JT. Rutka, GD. Bader, J. Reimand, A. Goldenberg, V. Ramaswamy, MD. Taylor,
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- $a While molecular subgrouping has revolutionized medulloblastoma classification, the extent of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to genome-wide DNA methylation and gene expression data across 763 primary samples identifies very homogeneous clusters of patients, supporting the presence of medulloblastoma subtypes. After integration of somatic copy-number alterations, and clinical features specific to each cluster, we identify 12 different subtypes of medulloblastoma. Integrative analysis using SNF further delineates group 3 from group 4 medulloblastoma, which is not as readily apparent through analyses of individual data types. Two clear subtypes of infants with Sonic Hedgehog medulloblastoma with disparate outcomes and biology are identified. Medulloblastoma subtypes identified through integrative clustering have important implications for stratification of future clinical trials.
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- $a Rampasek, Ladislav $u Department of Computer Science, University of Toronto, Toronto, ON M5S 2E4, Canada; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
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- $a Peacock, John $u The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A1, Canada.
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- $a Shih, David J H $u The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A1, Canada.
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- $a Luu, Betty $u The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
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- $a Garzia, Livia $u The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
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- $a Torchia, Jonathon $u The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A1, Canada.
- 700 1_
- $a Nor, Carolina $u The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
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- $a Morrissy, A Sorana $u The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
- 700 1_
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- 700 1_
- $a Thompson, Yuan Yao $u The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A1, Canada.
- 700 1_
- $a Kuzan-Fischer, Claudia M $u The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
- 700 1_
- $a Farooq, Hamza $u The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A1, Canada.
- 700 1_
- $a Isaev, Keren $u Informatics Program, Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada.
- 700 1_
- $a Daniels, Craig $u The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
- 700 1_
- $a Cho, Byung-Kyu $u Department of Neurosurgery, Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul 30322, South Korea.
- 700 1_
- $a Kim, Seung-Ki $u Department of Neurosurgery, Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul 30322, South Korea.
- 700 1_
- $a Wang, Kyu-Chang $u Department of Neurosurgery, Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul 30322, South Korea.
- 700 1_
- $a Lee, Ji Yeoun $u Department of Neurosurgery, Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul 30322, South Korea.
- 700 1_
- $a Grajkowska, Wieslawa A $u Department of Pathology, The Children's Memorial Health Institute, University of Warsaw, Warsaw 04-730, Poland.
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Jouvet, Anne $u Centre de Pathologie EST, Groupement Hospitalier EST, Université de Lyon, Bron 69677, France.
- 700 1_
- $a Giannini, Caterina $u Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.
- 700 1_
- $a Nageswara Rao, Amulya A $u Division of Pediatric Hematology/Oncology, Mayo Clinic, Rochester, MN 55905, USA.
- 700 1_
- $a Li, Kay Ka Wai $u Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.
- 700 1_
- $a Ng, Ho-Keung $u Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.
- 700 1_
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- 700 1_
- $a Pollack, Ian F $u Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
- 700 1_
- $a Hamilton, Ronald L $u Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
- 700 1_
- $a Gillespie, G Yancey $u Department of Surgery, Division of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
- 700 1_
- $a Olson, James M $u Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA; Division of Pediatric Hematology/Oncology, University of Washington School of Medicine, Seattle Children's Hospital, Seattle, WA 98145-5005, USA.
- 700 1_
- $a Leary, Sarah $u Division of Pediatric Hematology/Oncology, University of Washington School of Medicine, Seattle Children's Hospital, Seattle, WA 98145-5005, USA.
- 700 1_
- $a Weiss, William A $u Departments of Pediatrics, Neurological Surgery and Neurology, University of California San Francisco, San Francisco, CA 94143-0112, USA.
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Vibhakar, Rajeev $u Department of Pediatrics, University of Colorado Denver, Aurora, CO 80045, USA.
- 700 1_
- $a Hauser, Peter $u 2nd Department of Pediatrics, Semmelweis University, Budapest 1094, Hungary.
- 700 1_
- $a van Veelen, Marie-Lise C $u Department of Neurosurgery, Erasmus University Medical Center, Rotterdam 3015 CE, the Netherlands.
- 700 1_
- $a Kros, Johan M $u Department of Pathology, Erasmus University Medical Center, Rotterdam 3015 CN, the Netherlands.
- 700 1_
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- 700 1_
- $a Ra, Young Shin $u Department of Neurosurgery, University of Ulsan, Asan Medical Center, Seoul 05505, South Korea.
- 700 1_
- $a Kumabe, Toshihiro $u Department of Neurosurgery, Kitasato University School of Medicine, Sagamihara, Kanagawa 252-0374, Japan.
- 700 1_
- $a López-Aguilar, Enrique $u Division of Pediatric Hematology/Oncology, Hospital Pediatría Centro Médico Nacional Century XXI, Mexico City 06720, Mexico.
- 700 1_
- $a Zitterbart, Karel $u Department of Pediatric Oncology, School of Medicine, Masaryk University, Brno 625 00, Czech Republic.
- 700 1_
- $a Sterba, Jaroslav $u Department of Pediatric Oncology, School of Medicine, Masaryk University, Brno 625 00, Czech Republic.
- 700 1_
- $a Finocchiaro, Gaetano $u Department of Neuro-Oncology, Istituto Neurologico Besta, Milan 20133, Italy.
- 700 1_
- $a Massimino, Maura $u Fondazione IRCCS Istituto Nazionale Tumori, Milan 20133, Italy.
- 700 1_
- $a Van Meir, Erwin G $u Department of Hematology & Medical Oncology, School of Medicine and Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA.
- 700 1_
- $a Osuka, Satoru $u Department of Hematology & Medical Oncology, School of Medicine and Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA.
- 700 1_
- $a Shofuda, Tomoko $u Division of Stem Cell Research, Institute for Clinical Research, Osaka National Hospital, Osaka 540-0006, Japan.
- 700 1_
- $a Klekner, Almos $u Department of Neurosurgery, University of Debrecen, Medical and Health Science Centre, Debrecen 4032, Hungary.
- 700 1_
- $a Zollo, Massimo $u Dipartimento di Biochimica e Biotecnologie Mediche, University of Naples, Naples 80145, Italy.
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Hallahan, Andrew R $u Lady Cilento Children's Hospital, The University of Queensland, Brisbane QLD 4102, Australia; Oncology Service, Children's Health Queensland Hospital and Health Service, South Brisbane, QLD 4029, Australia.
- 700 1_
- $a Chan, Jennifer A $u Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB T2N 2T9, Canada.
- 700 1_
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- 700 1_
- $a Carlotti, Carlos G $u Department of Surgery and Anatomy, Faculty of Medicine of Ribeirão Preto, University of São Paulo, São Paulo 14049-900, Brazil.
- 700 1_
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- 700 1_
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- 700 1_
- $a Faria, Claudia C $u Division of Neurosurgery, Centro Hospitalar Lisboa Norte, Hospital de Santa Maria, Lisbon 1649-035, Portugal.
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Huang, Annie $u The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Division of Haematology / Oncology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
- 700 1_
- $a Hawkins, Cynthia E $u The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Division of Pathology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
- 700 1_
- $a Tabori, Uri $u The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Division of Haematology / Oncology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
- 700 1_
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- 700 1_
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- 700 1_
- $a Dirks, Peter B $u The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
- 700 1_
- $a Rutka, James T $u The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A1, Canada; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
- 700 1_
- $a Bader, Gary D $u The Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada; Banting and Best Department of Medical Research, University of Toronto, Toronto, ON M5G 1L6, Canada; McLaughlin Centre, University of Toronto, Toronto, ON M5G 0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; Samuel Lunenfeld Research Institute at Mount Sinai Hospital, University of Toronto, Toronto, ON M5G 1X5, Canada.
- 700 1_
- $a Reimand, Jüri $u Informatics Program, Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada.
- 700 1_
- $a Goldenberg, Anna $u Department of Computer Science, University of Toronto, Toronto, ON M5S 2E4, Canada; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada. Electronic address: anna.goldenberg@utoronto.ca.
- 700 1_
- $a Ramaswamy, Vijay $u The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Division of Haematology / Oncology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Program in Neuroscience and Mental Health and Division of Neurology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada. Electronic address: vijay.ramaswamy@sickkids.ca.
- 700 1_
- $a Taylor, Michael D $u The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A1, Canada; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada. Electronic address: mdtaylor@sickkids.ca.
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