• Je něco špatně v tomto záznamu ?

A minimum number of autoimmune T cells to induce autoimmunity

AJT. Bosch, B. Bolinger, S. Keck, O. Stepanek, AJ. Ozga, V. Galati-Fournier, JV. Stein, E. Palmer,

. 2017 ; 316 (-) : 21-31. [pub] 20170312

Jazyk angličtina Země Nizozemsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc17030919

While autoimmune T cells are present in most individuals, only a minority of the population suffers from an autoimmune disease. To better appreciate the limits of T cell tolerance, we carried out experiments to determine how many autoimmune T cells are required to initiate an experimental autoimmune disease. Variable numbers of autoimmune OT-I T cells were transferred into RIP-OVA mice, which were injected with antigen-loaded DCs in a single footpad; this restricted T cell priming to a few OT-I T cells that are present in the draining popliteal lymph node. Using selective plane illumination microscopy (SPIM) we counted the number of OT-I T cells present in the popliteal lymph node at the time of priming. Analysis of our data suggests that a single autoimmune T cell cannot induce an experimental autoimmune disease, but a "quorum" of 2-5 autoimmune T cells clearly has this capacity.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc17030919
003      
CZ-PrNML
005      
20171030113041.0
007      
ta
008      
171025s2017 ne f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.cellimm.2017.03.002 $2 doi
035    __
$a (PubMed)28366195
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a ne
100    1_
$a Bosch, Angela J T $u Departments of Biomedicine and Nephrology, University Hospital Basel and University of Basel, 4031 Basel, Switzerland.
245    12
$a A minimum number of autoimmune T cells to induce autoimmunity / $c AJT. Bosch, B. Bolinger, S. Keck, O. Stepanek, AJ. Ozga, V. Galati-Fournier, JV. Stein, E. Palmer,
520    9_
$a While autoimmune T cells are present in most individuals, only a minority of the population suffers from an autoimmune disease. To better appreciate the limits of T cell tolerance, we carried out experiments to determine how many autoimmune T cells are required to initiate an experimental autoimmune disease. Variable numbers of autoimmune OT-I T cells were transferred into RIP-OVA mice, which were injected with antigen-loaded DCs in a single footpad; this restricted T cell priming to a few OT-I T cells that are present in the draining popliteal lymph node. Using selective plane illumination microscopy (SPIM) we counted the number of OT-I T cells present in the popliteal lymph node at the time of priming. Analysis of our data suggests that a single autoimmune T cell cannot induce an experimental autoimmune disease, but a "quorum" of 2-5 autoimmune T cells clearly has this capacity.
650    _2
$a převzatá imunita $7 D019264
650    _2
$a zvířata $7 D000818
650    _2
$a prezentace antigenu $7 D017951
650    _2
$a autoimunitní nemoci $x imunologie $7 D001327
650    12
$a autoimunita $7 D015551
650    _2
$a CD8-pozitivní T-lymfocyty $x cytologie $x imunologie $7 D018414
650    _2
$a dendritické buňky $x imunologie $7 D003713
650    _2
$a experimentální diabetes mellitus $x imunologie $7 D003921
650    _2
$a modely nemocí na zvířatech $7 D004195
650    _2
$a imunologická tolerance $7 D007108
650    _2
$a lymfatické uzliny $x cytologie $x imunologie $7 D008198
650    _2
$a myši $7 D051379
650    _2
$a myši transgenní $7 D008822
650    _2
$a ovalbumin $x imunologie $7 D010047
655    _2
$a časopisecké články $7 D016428
700    1_
$a Bolinger, Beatrice $u Departments of Biomedicine and Nephrology, University Hospital Basel and University of Basel, 4031 Basel, Switzerland.
700    1_
$a Keck, Simone $u Departments of Biomedicine and Nephrology, University Hospital Basel and University of Basel, 4031 Basel, Switzerland.
700    1_
$a Stepanek, Ondrej $u Departments of Biomedicine and Nephrology, University Hospital Basel and University of Basel, 4031 Basel, Switzerland; Institute of Molecular Genetics, Czech Academy of Sciences, 142 20 Prague, Czech Republic.
700    1_
$a Ozga, Aleksandra J $u Theodor Kocher Institute, University of Bern, 3012 Bern, Switzerland.
700    1_
$a Galati-Fournier, Virginie $u Departments of Biomedicine and Nephrology, University Hospital Basel and University of Basel, 4031 Basel, Switzerland.
700    1_
$a Stein, Jens V $u Theodor Kocher Institute, University of Bern, 3012 Bern, Switzerland.
700    1_
$a Palmer, Ed $u Departments of Biomedicine and Nephrology, University Hospital Basel and University of Basel, 4031 Basel, Switzerland. Electronic address: ed.palmer@unibas.ch.
773    0_
$w MED00001079 $t Cellular immunology $x 1090-2163 $g Roč. 316, č. - (2017), s. 21-31
856    41
$u https://pubmed.ncbi.nlm.nih.gov/28366195 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20171025 $b ABA008
991    __
$a 20171030113130 $b ABA008
999    __
$a ok $b bmc $g 1254512 $s 991946
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2017 $b 316 $c - $d 21-31 $e 20170312 $i 1090-2163 $m Cellular immunology $n Cell Immunol $x MED00001079
LZP    __
$a Pubmed-20171025
Zpět

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace