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Molecular mechanisms of thermal resistance of the insect trypanosomatid Crithidia thermophila
A. Ishemgulova, A. Butenko, L. Kortišová, C. Boucinha, A. Grybchuk-Ieremenko, KA. Morelli, M. Tesařová, N. Kraeva, D. Grybchuk, T. Pánek, P. Flegontov, J. Lukeš, J. Votýpka, MG. Pavan, FR. Opperdoes, V. Spodareva, CM. d'Avila-Levy, AY. Kostygov,...
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
NLK
Directory of Open Access Journals
od 2006
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Public Library of Science (PLoS)
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od 2008-01-01
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- MeSH
- biochemické jevy genetika MeSH
- Crithidia genetika MeSH
- exprese genu genetika MeSH
- hmyz genetika MeSH
- teplota MeSH
- transkriptom genetika MeSH
- upregulace genetika MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
In the present work, we investigated molecular mechanisms governing thermal resistance of a monoxenous trypanosomatid Crithidia luciliae thermophila, which we reclassified as a separate species C. thermophila. We analyzed morphology, growth kinetics, and transcriptomic profiles of flagellates cultivated at low (23°C) and elevated (34°C) temperature. When maintained at high temperature, they grew significantly faster, became shorter, with genes involved in sugar metabolism and mitochondrial stress protection significantly upregulated. Comparison with another thermoresistant monoxenous trypanosomatid, Leptomonas seymouri, revealed dramatic differences in transcription profiles of the two species with only few genes showing the same expression pattern. This disparity illustrates differences in the biology of these two parasites and distinct mechanisms of their thermotolerance, a prerequisite for living in warm-blooded vertebrates.
Biology Centre Institute of Parasitology Czech Academy of Sciences České Budějovice Czech Republic
e Duve Institute Université Catholique de Louvain Brussels Belgium
Life Science Research Centre Faculty of Science University of Ostrava Ostrava Czech Republic
Citace poskytuje Crossref.org
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- $a Ishemgulova, Aygul $u Life Science Research Centre, Faculty of Science, University of Ostrava, Ostrava, Czech Republic. Biology Centre, Institute of Parasitology, Czech Academy of Sciences, České Budějovice (Budweis), Czech Republic.
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