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Molecular mechanisms of thermal resistance of the insect trypanosomatid Crithidia thermophila
A. Ishemgulova, A. Butenko, L. Kortišová, C. Boucinha, A. Grybchuk-Ieremenko, KA. Morelli, M. Tesařová, N. Kraeva, D. Grybchuk, T. Pánek, P. Flegontov, J. Lukeš, J. Votýpka, MG. Pavan, FR. Opperdoes, V. Spodareva, CM. d'Avila-Levy, AY. Kostygov,...
Language English Country United States
Document type Journal Article
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- MeSH
- Biochemical Phenomena genetics MeSH
- Crithidia genetics MeSH
- Gene Expression genetics MeSH
- Insecta genetics MeSH
- Temperature MeSH
- Transcriptome genetics MeSH
- Up-Regulation genetics MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
In the present work, we investigated molecular mechanisms governing thermal resistance of a monoxenous trypanosomatid Crithidia luciliae thermophila, which we reclassified as a separate species C. thermophila. We analyzed morphology, growth kinetics, and transcriptomic profiles of flagellates cultivated at low (23°C) and elevated (34°C) temperature. When maintained at high temperature, they grew significantly faster, became shorter, with genes involved in sugar metabolism and mitochondrial stress protection significantly upregulated. Comparison with another thermoresistant monoxenous trypanosomatid, Leptomonas seymouri, revealed dramatic differences in transcription profiles of the two species with only few genes showing the same expression pattern. This disparity illustrates differences in the biology of these two parasites and distinct mechanisms of their thermotolerance, a prerequisite for living in warm-blooded vertebrates.
Biology Centre Institute of Parasitology Czech Academy of Sciences České Budějovice Czech Republic
e Duve Institute Université Catholique de Louvain Brussels Belgium
Life Science Research Centre Faculty of Science University of Ostrava Ostrava Czech Republic
References provided by Crossref.org
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- $a Ishemgulova, Aygul $u Life Science Research Centre, Faculty of Science, University of Ostrava, Ostrava, Czech Republic. Biology Centre, Institute of Parasitology, Czech Academy of Sciences, České Budějovice (Budweis), Czech Republic.
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- $a Molecular mechanisms of thermal resistance of the insect trypanosomatid Crithidia thermophila / $c A. Ishemgulova, A. Butenko, L. Kortišová, C. Boucinha, A. Grybchuk-Ieremenko, KA. Morelli, M. Tesařová, N. Kraeva, D. Grybchuk, T. Pánek, P. Flegontov, J. Lukeš, J. Votýpka, MG. Pavan, FR. Opperdoes, V. Spodareva, CM. d'Avila-Levy, AY. Kostygov, V. Yurchenko,
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- $a In the present work, we investigated molecular mechanisms governing thermal resistance of a monoxenous trypanosomatid Crithidia luciliae thermophila, which we reclassified as a separate species C. thermophila. We analyzed morphology, growth kinetics, and transcriptomic profiles of flagellates cultivated at low (23°C) and elevated (34°C) temperature. When maintained at high temperature, they grew significantly faster, became shorter, with genes involved in sugar metabolism and mitochondrial stress protection significantly upregulated. Comparison with another thermoresistant monoxenous trypanosomatid, Leptomonas seymouri, revealed dramatic differences in transcription profiles of the two species with only few genes showing the same expression pattern. This disparity illustrates differences in the biology of these two parasites and distinct mechanisms of their thermotolerance, a prerequisite for living in warm-blooded vertebrates.
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- $a Opperdoes, Fred R $u de Duve Institute, Université Catholique de Louvain, Brussels, Belgium.
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