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Tracking T-cell immune reconstitution after TCRαβ/CD19-depleted hematopoietic cells transplantation in children
IV. Zvyagin, IZ. Mamedov, OV. Tatarinova, EA. Komech, EE. Kurnikova, EV. Boyakova, V. Brilliantova, LN. Shelikhova, DN. Balashov, M. Shugay, AL. Sycheva, SA. Kasatskaya, YB. Lebedev, AA. Maschan, MA. Maschan, DM. Chudakov,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články
NLK
ProQuest Central
od 2000-01-01 do Před 1 rokem
Open Access Digital Library
od 1997-01-01
Nursing & Allied Health Database (ProQuest)
od 2000-01-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 2000-01-01 do Před 1 rokem
Public Health Database (ProQuest)
od 2000-01-01 do Před 1 rokem
PubMed
27811849
DOI
10.1038/leu.2016.321
Knihovny.cz E-zdroje
- MeSH
- antigeny CD19 * MeSH
- časové faktory MeSH
- dítě MeSH
- kojenec MeSH
- krevní nemoci terapie MeSH
- lidé MeSH
- lymfocytární deplece metody MeSH
- mladiství MeSH
- mladý dospělý MeSH
- předškolní dítě MeSH
- přežívání štěpu * MeSH
- receptory antigenů T-buněk alfa-beta * MeSH
- T-lymfocyty imunologie MeSH
- transplantace hematopoetických kmenových buněk metody MeSH
- Check Tag
- dítě MeSH
- kojenec MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- předškolní dítě MeSH
- Publikační typ
- časopisecké články MeSH
αβT-cell-depleted allogeneic hematopoietic cell transplantation holds promise for the safe and accessible therapy of both malignant and non-malignant blood disorders. Here we employed molecular barcoding normalized T-cell receptor (TCR) profiling to quantitatively track T-cell immune reconstitution after TCRαβ-/CD19-depleted transplantation in children. We demonstrate that seemingly early reconstitution of αβT-cell counts 2 months after transplantation is based on only several hundred rapidly expanded clones originating from non-depleted graft cells. In further months, frequency of these hyperexpanded clones declines, and after 1 year the observed T-cell counts and TCRβ diversity are mostly provided by the newly produced T cells. We also demonstrate that high TCRβ diversity at day 60 observed for some of the patients is determined by recipient T cells and intrathymic progenitors that survived conditioning regimen. Our results indicate that further efforts on optimization of TCRαβ-/CD19-depleted transplantation protocols should be directed toward providing more efficient T-cell defense in the first months after transplantation.
Citace poskytuje Crossref.org
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