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Tcf7l1 protects the anterior neural fold from adopting the neural crest fate
J. Mašek, O. Machoň, V. Kořínek, MM. Taketo, Z. Kozmik,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články
NLK
Free Medical Journals
od 1953 do Před 6 měsíci
Open Access Digital Library
od 1953-03-01 do Před 6 měsíci
PubMed
27302397
DOI
10.1242/dev.132357
Knihovny.cz E-zdroje
- MeSH
- beta-katenin metabolismus MeSH
- biologické markery metabolismus MeSH
- buněčný rodokmen * MeSH
- crista neuralis cytologie metabolismus MeSH
- dánio pruhované metabolismus MeSH
- defekty neurální trubice metabolismus patologie MeSH
- delece genu MeSH
- fenotyp MeSH
- integrasy metabolismus MeSH
- lidé MeSH
- myši transgenní MeSH
- přední mozek embryologie metabolismus MeSH
- protein 1 podobný transkripčnímu faktoru 7 metabolismus MeSH
- proteiny dánia pruhovaného metabolismus MeSH
- represorové proteiny metabolismus MeSH
- signální dráha Wnt MeSH
- transdiferenciace buněk MeSH
- transkripční faktor AP-2 metabolismus MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
The neural crest (NC) is crucial for the evolutionary diversification of vertebrates. NC cells are induced at the neural plate border by the coordinated action of several signaling pathways, including Wnt/β-catenin. NC cells are normally generated in the posterior neural plate border, whereas the anterior neural fold is devoid of NC cells. Using the mouse model, we show here that active repression of Wnt/β-catenin signaling is required for maintenance of neuroepithelial identity in the anterior neural fold and for inhibition of NC induction. Conditional inactivation of Tcf7l1, a transcriptional repressor of Wnt target genes, leads to aberrant activation of Wnt/β-catenin signaling in the anterior neuroectoderm and its conversion into NC. This reduces the developing prosencephalon without affecting the anterior-posterior neural character. Thus, Tcf7l1 defines the border between the NC and the prospective forebrain via restriction of the Wnt/β-catenin signaling gradient.
Citace poskytuje Crossref.org
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- $a The neural crest (NC) is crucial for the evolutionary diversification of vertebrates. NC cells are induced at the neural plate border by the coordinated action of several signaling pathways, including Wnt/β-catenin. NC cells are normally generated in the posterior neural plate border, whereas the anterior neural fold is devoid of NC cells. Using the mouse model, we show here that active repression of Wnt/β-catenin signaling is required for maintenance of neuroepithelial identity in the anterior neural fold and for inhibition of NC induction. Conditional inactivation of Tcf7l1, a transcriptional repressor of Wnt target genes, leads to aberrant activation of Wnt/β-catenin signaling in the anterior neuroectoderm and its conversion into NC. This reduces the developing prosencephalon without affecting the anterior-posterior neural character. Thus, Tcf7l1 defines the border between the NC and the prospective forebrain via restriction of the Wnt/β-catenin signaling gradient.
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