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Subcortical volumetric abnormalities in bipolar disorder
DP. Hibar, LT. Westlye, TG. van Erp, J. Rasmussen, CD. Leonardo, J. Faskowitz, UK. Haukvik, CB. Hartberg, NT. Doan, I. Agartz, AM. Dale, O. Gruber, B. Krämer, S. Trost, B. Liberg, C. Abé, CJ. Ekman, M. Ingvar, M. Landén, SC. Fears, NB. Freimer,...
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články
NLK
ProQuest Central
od 1997-01-01 do 2017-12-31
Open Access Digital Library
od 1997-01-01
Health & Medicine (ProQuest)
od 1997-01-01 do 2017-12-31
Psychology Database (ProQuest)
od 1997-01-01 do 2017-12-31
PubMed
26857596
DOI
10.1038/mp.2015.227
Knihovny.cz E-zdroje
- MeSH
- bipolární porucha patofyziologie MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- magnetická rezonanční tomografie metody MeSH
- mozek anatomie a histologie patofyziologie MeSH
- retrospektivní studie MeSH
- studie případů a kontrol MeSH
- velikost orgánu fyziologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Considerable uncertainty exists about the defining brain changes associated with bipolar disorder (BD). Understanding and quantifying the sources of uncertainty can help generate novel clinical hypotheses about etiology and assist in the development of biomarkers for indexing disease progression and prognosis. Here we were interested in quantifying case-control differences in intracranial volume (ICV) and each of eight subcortical brain measures: nucleus accumbens, amygdala, caudate, hippocampus, globus pallidus, putamen, thalamus, lateral ventricles. In a large study of 1710 BD patients and 2594 healthy controls, we found consistent volumetric reductions in BD patients for mean hippocampus (Cohen's d=-0.232; P=3.50 × 10(-7)) and thalamus (d=-0.148; P=4.27 × 10(-3)) and enlarged lateral ventricles (d=-0.260; P=3.93 × 10(-5)) in patients. No significant effect of age at illness onset was detected. Stratifying patients based on clinical subtype (BD type I or type II) revealed that BDI patients had significantly larger lateral ventricles and smaller hippocampus and amygdala than controls. However, when comparing BDI and BDII patients directly, we did not detect any significant differences in brain volume. This likely represents similar etiology between BD subtype classifications. Exploratory analyses revealed significantly larger thalamic volumes in patients taking lithium compared with patients not taking lithium. We detected no significant differences between BDII patients and controls in the largest such comparison to date. Findings in this study should be interpreted with caution and with careful consideration of the limitations inherent to meta-analyzed neuroimaging comparisons.
Academic Psychiatry and Regional Affective Disorders Service Newcastle University Newcastle UK
Center for Neurobehavioral Genetics University of California Los Angeles CA USA
Centre for Affective Disorders King's College London London UK
Department of Clinical Neuroscience Section of Psychiatry Karolinska Institutet Stockholm Sweden
Department of Psychiatry and Human Behavior University of California Irvine CA USA
Department of Psychiatry Brown University Providence RI USA
Department of Psychiatry Dalhousie University Halifax Canada
Department of Psychiatry Icahn School of Medicine at Mount Sinai New York NY USA
Department of Psychiatry University of Oxford Oxford UK
Department of Psychiatry University of Pennsylvania Perelman School of Medicine Philadelphia PA USA
Division of Psychiatry University of Edinburgh Edinburgh UK
Imaging Genetics Center University of Southern California Los Angeles CA USA
Institute of Psychiatry Psychology and Neuroscience King's College London London UK
Osher Center for Integrative Medicine Karolinska Institutet Stockholm Sweden
Citace poskytuje Crossref.org
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