-
Je něco špatně v tomto záznamu ?
The role of keratinocytes in inflammation
Jana Juráňová, Jana Franková, Jitka Ulrichová
Jazyk angličtina Země Česko
Typ dokumentu přehledy, práce podpořená grantem
- MeSH
- cytokiny MeSH
- fyziologie kůže MeSH
- hojení ran fyziologie MeSH
- interleukin 33 MeSH
- interleukin-1alfa MeSH
- interleukin-1beta MeSH
- keratinocyty * fyziologie MeSH
- kůže * zranění MeSH
- lidé MeSH
- mediátory zánětu fyziologie MeSH
- NF-kappa B MeSH
- protein NLRP3 MeSH
- toll-like receptory MeSH
- zánět * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- práce podpořená grantem MeSH
- přehledy MeSH
The epidermis is the external layer of the skin and is composed mainly of keratinocytes. Therefore, keratinocytes play an indispensable role as inherent constituents of the skin barrier in physical defenses against environmental threats. Keratinocytes also exert an active protective role against invasion by pathogens. This competency is of particular importance when physical defenses fail as a consequence of skin injury. During the inflammatory phase of healing, keratinocytes act as immuno-modulators, managing inflammation via a rigorously coordinated network of inflammatory cascades, triggered by keratinocyte-receptor communication with the surroundings in a paracrine and autocrine manner. This review summarizes current understandings of the coordinated inflammatory network and focuses on recent progress regarding the role of keratinocytes in early phases of skin wound healing.
Citace poskytuje Crossref.org
Literatura
- 000
- 00000naa a2200000 a 4500
- 001
- bmc17032796
- 003
- CZ-PrNML
- 005
- 20180321154318.0
- 007
- ta
- 008
- 171108s2017 xr a f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.jab.2017.05.003 $2 doi
- 040 __
- $a ABA008 $d ABA008 $e AACR2 $b cze
- 041 0_
- $a eng
- 044 __
- $a xr
- 100 1_
- $a Juráňová, Jana $7 xx0302502 $u Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic
- 245 14
- $a The role of keratinocytes in inflammation / $c Jana Juráňová, Jana Franková, Jitka Ulrichová
- 504 __
- $a Literatura
- 520 9_
- $a The epidermis is the external layer of the skin and is composed mainly of keratinocytes. Therefore, keratinocytes play an indispensable role as inherent constituents of the skin barrier in physical defenses against environmental threats. Keratinocytes also exert an active protective role against invasion by pathogens. This competency is of particular importance when physical defenses fail as a consequence of skin injury. During the inflammatory phase of healing, keratinocytes act as immuno-modulators, managing inflammation via a rigorously coordinated network of inflammatory cascades, triggered by keratinocyte-receptor communication with the surroundings in a paracrine and autocrine manner. This review summarizes current understandings of the coordinated inflammatory network and focuses on recent progress regarding the role of keratinocytes in early phases of skin wound healing.
- 650 _2
- $a lidé $7 D006801
- 650 12
- $a keratinocyty $x fyziologie $7 D015603
- 650 12
- $a zánět $7 D007249
- 650 _2
- $a hojení ran $x fyziologie $7 D014945
- 650 12
- $a kůže $x zranění $7 D012867
- 650 _2
- $a fyziologie kůže $7 D012879
- 650 _2
- $a cytokiny $7 D016207
- 650 _2
- $a protein NLRP3 $7 D000071199
- 650 _2
- $a NF-kappa B $7 D016328
- 650 _2
- $a interleukin-1alfa $7 D053582
- 650 _2
- $a interleukin-1beta $7 D053583
- 650 _2
- $a interleukin 33 $7 D000067596
- 650 _2
- $a toll-like receptory $7 D051193
- 650 _2
- $a mediátory zánětu $x fyziologie $7 D018836
- 655 _2
- $a přehledy $7 D016454
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Franková, Jana, $d 1977- $7 xx0170506 $u Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic
- 700 1_
- $a Ulrichová, Jitka, $d 1956- $7 ola2002158251 $u Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic
- 773 0_
- $t Journal of applied biomedicine $x 1214-021X $g Roč. 15, č. 3 (2017), s. 169-179 $w MED00012667
- 856 41
- $u https://jab.zsf.jcu.cz/pdfs/jab/2017/03/02.pdf $y plný text volně přístupný
- 910 __
- $a ABA008 $b B 2301 $c 1249 $y 4 $z 0
- 990 __
- $a 20171108135554 $b ABA008
- 991 __
- $a 20180321154336 $b ABA008
- 999 __
- $a ok $b bmc $g 1257823 $s 993833
- BAS __
- $a 3
- BMC __
- $a 2017 $b 15 $c 3 $d 169-179 $i 1214-021X $m Journal of Applied Biomedicine $x MED00012667
- LZP __
- $c NLK188 $d 20180321 $a NLK 2017-44/dk
