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Impact of hormonal changes on the semen quality and assisted reproductive outcomes in infertile men
Fatemeh Ghasemian, Seyed Abolghasem Mirroshandel, Ziba Zahiri
Language English Country Czech Republic
- MeSH
- Reproductive Techniques, Assisted * MeSH
- Chromatin genetics MeSH
- Adult MeSH
- Follicle Stimulating Hormone blood MeSH
- Middle Aged MeSH
- Humans MeSH
- Luteinizing Hormone blood MeSH
- Young Adult MeSH
- Sperm Motility MeSH
- Infertility, Male * blood therapy MeSH
- Sperm Count MeSH
- DNA Damage MeSH
- Abortion, Spontaneous MeSH
- Pregnancy statistics & numerical data MeSH
- Testosterone blood MeSH
- Treatment Outcome MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Pregnancy statistics & numerical data MeSH
- Female MeSH
This study investigated the effect of hormonal changes on semen quality, chromatin status, and assisted reproductive outcomes (intracytoplasmic sperm injection), among infertile men. In this research, 219 infertile men undergoing assisted reproductive treatment were evaluated with reproductive hormone levels (including follicle-stimulating hormone, luteinizing hormone and testosterone), semen parameters, and sperm chromatin integrity and condensation, between 2012 and 2014. Finally, the assisted reproductive outcomes in these infertile men were studied. The low rate of total sperm count, motility and morphology, fertilization and the high percentage of DNA damage, the poor zygote (Z4 grade) and embryo quality (grade D), and spontaneous miscarriage was recorded in men with high levels of follicle-stimulating hormone and luteinizing hormone. In conclusion, the changes in the follicle-stimulating hormone, luteinizing hormone, and testosterone by changes in the sperm quality, and DNA damage may have the effects on assisted reproductive outcomes (e.g., low fertilization, poor zygote and embryo quality, and high miscarriage).
Department of Biology University of Guilan Rasht Iran
Department of Computer Engineering University of Guilan Rasht Iran
References provided by Crossref.org
Literatura
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- $a This study investigated the effect of hormonal changes on semen quality, chromatin status, and assisted reproductive outcomes (intracytoplasmic sperm injection), among infertile men. In this research, 219 infertile men undergoing assisted reproductive treatment were evaluated with reproductive hormone levels (including follicle-stimulating hormone, luteinizing hormone and testosterone), semen parameters, and sperm chromatin integrity and condensation, between 2012 and 2014. Finally, the assisted reproductive outcomes in these infertile men were studied. The low rate of total sperm count, motility and morphology, fertilization and the high percentage of DNA damage, the poor zygote (Z4 grade) and embryo quality (grade D), and spontaneous miscarriage was recorded in men with high levels of follicle-stimulating hormone and luteinizing hormone. In conclusion, the changes in the follicle-stimulating hormone, luteinizing hormone, and testosterone by changes in the sperm quality, and DNA damage may have the effects on assisted reproductive outcomes (e.g., low fertilization, poor zygote and embryo quality, and high miscarriage).
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