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Protease Inhibitors in Tick Saliva: The Role of Serpins and Cystatins in Tick-host-Pathogen Interaction
J. Chmelař, J. Kotál, H. Langhansová, M. Kotsyfakis,
Language English Country Switzerland
Document type Journal Article, Review, Research Support, Non-U.S. Gov't
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- MeSH
- Cystatins physiology therapeutic use MeSH
- Immunomodulation MeSH
- Protease Inhibitors classification metabolism therapeutic use MeSH
- Serine Proteinase Inhibitors physiology therapeutic use MeSH
- Host-Parasite Interactions MeSH
- Ticks metabolism MeSH
- Humans MeSH
- Serpins physiology therapeutic use MeSH
- Saliva enzymology metabolism MeSH
- Transcriptome MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
The publication of the first tick sialome (salivary gland transcriptome) heralded a new era of research of tick protease inhibitors, which represent important constituents of the proteins secreted via tick saliva into the host. Three major groups of protease inhibitors are secreted into saliva: Kunitz inhibitors, serpins, and cystatins. Kunitz inhibitors are anti-hemostatic agents and tens of proteins with one or more Kunitz domains are known to block host coagulation and/or platelet aggregation. Serpins and cystatins are also anti-hemostatic effectors, but intriguingly, from the translational perspective, also act as pluripotent modulators of the host immune system. Here we focus especially on this latter aspect of protease inhibition by ticks and describe the current knowledge and data on secreted salivary serpins and cystatins and their role in tick-host-pathogen interaction triad. We also discuss the potential therapeutic use of tick protease inhibitors.
Faculty of Science University of South Bohemia in České BudějoviceČeské Budějovice Czechia
Institute of Parasitology Biology Center Czech Academy of SciencesČeské Budějovice Czechia
References provided by Crossref.org
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