The publication of the first tick sialome (salivary gland transcriptome) heralded a new era of research of tick protease inhibitors, which represent important constituents of the proteins secreted via tick saliva into the host. Three major groups of protease inhibitors are secreted into saliva: Kunitz inhibitors, serpins, and cystatins. Kunitz inhibitors are anti-hemostatic agents and tens of proteins with one or more Kunitz domains are known to block host coagulation and/or platelet aggregation. Serpins and cystatins are also anti-hemostatic effectors, but intriguingly, from the translational perspective, also act as pluripotent modulators of the host immune system. Here we focus especially on this latter aspect of protease inhibition by ticks and describe the current knowledge and data on secreted salivary serpins and cystatins and their role in tick-host-pathogen interaction triad. We also discuss the potential therapeutic use of tick protease inhibitors.

• MeSH
• cystatiny fyziologie   terapeutické užití   MeSH
• imunomodulace MeSH
• inhibitory proteas klasifikace   metabolismus   terapeutické užití   MeSH
• inhibitory serinových proteinas fyziologie   terapeutické užití   MeSH
• interakce hostitele a parazita MeSH
• klíšťata metabolismus   MeSH
• lidé MeSH
• serpiny fyziologie   terapeutické užití   MeSH
• sliny enzymologie   metabolismus   MeSH
• transkriptom MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• přehledy MeSH