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Immunomodulatory effects of stem cells: Therapeutic option for neurodegenerative disorders
M. Caprnda, P. Kubatka, K. Gazdikova, I. Gasparova, V. Valentova, N. Stollarova, G. La Rocca, N. Kobyliak, J. Dragasek, I. Mozos, R. Prosecky, D. Siniscalco, D. Büsselberg, L. Rodrigo, P. Kruzliak,
Jazyk angličtina Země Francie
Typ dokumentu časopisecké články, přehledy
- MeSH
- biologické modely MeSH
- imunologické faktory metabolismus MeSH
- kmenové buňky metabolismus MeSH
- lidé MeSH
- neurodegenerativní nemoci terapie MeSH
- transplantace kmenových buněk * MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Stem cells have the capability of self-renewal and can differentiate into different cell types that might be used in regenerative medicine. Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS) currently lack effective treatments. Although stem cell therapy is still on the way from bench to bedside, we consider that it might provide new hope for patients suffering with neurodegenerative diseases. In this article, we will give an overview of recent studies on the potential therapeutic use of mesenchymal stem cells (MSCs), neural stem cells (NSCs), embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and perinatal stem cells to neurodegenerative disorders and we will describe their immunomodulatory mechanisms of action in specific therapeutic modalities.
2nd Department of Surgery Faculty of Medicine St Annés University Hospital Brno Czech Republic
Department of Experimental Medicine University of Campania Luigi Vanvitelli Naples Italy
Department of General Medicine Faculty of Medicine Slovak Medical University Bratislava Slovakia
Department of Internal Medicine Merciful Brotherś Hospital Brno Czech Republic
Department of Medical Biology Jessenius Faculty of Medicine Comenius University Martin Slovakia
Endocrinology Department Bogomolets National Medical University Kyiv Ukraine
University of Oviedo Central University Hospital of Asturias Oviedo Spain
Weill Cornell Medical College in Qatar Qatar Foundation Education City Doha Qatar
Citace poskytuje Crossref.org
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- $a Caprnda, Martin $u 1st Department of Internal Medicine, Faculty of Medicine, Comenius University and University Hospital, Bratislava, Slovakia.
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- $a Stem cells have the capability of self-renewal and can differentiate into different cell types that might be used in regenerative medicine. Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS) currently lack effective treatments. Although stem cell therapy is still on the way from bench to bedside, we consider that it might provide new hope for patients suffering with neurodegenerative diseases. In this article, we will give an overview of recent studies on the potential therapeutic use of mesenchymal stem cells (MSCs), neural stem cells (NSCs), embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and perinatal stem cells to neurodegenerative disorders and we will describe their immunomodulatory mechanisms of action in specific therapeutic modalities.
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- $a Kubatka, Peter $u Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia; Division of Oncology, Biomedical Center Martin, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia.
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- $a Gazdikova, Katarina $u Department of Nutrition, Faculty of Nursing and Professional Health Studies, Slovak Medical University, Bratislava, Slovakia; Department of General Medicine, Faculty of Medicine, Slovak Medical University, Bratislava, Slovakia. Electronic address: katarina.gazdikova@szu.sk.
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- $a Kruzliak, Peter $u Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic; 2nd Department of Surgery, Faculty of Medicine,St. Annés University Hospital, Brno, Czech Republic. Electronic address: kruzliakpeter@gmail.com.
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